DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and KIT

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001372213.1	Gene:	KIT / 3815	HGNCID:	6342	Length:	977	Species:	Homo sapiens

Alignment Length:	754	Identity:	201/754 - (26%)
Similarity:	318/754 - (42%)	Gaps:	185/754 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 KMSFLQTRPSGSLLTLNCHALGNPEPNI--TWYRNGTV---------DWTRGYGSLKRNRWTLTM 161
            |.|:|..  .|...|:.| .:.:...::  ||.|..:.         .|..|..:.:|.. |||:
Human   218 KASYLLR--EGEEFTVTC-TIKDVSSSVYSTWKRENSQQTKLQEKYNSWHHGDFNYERQA-TLTI 278

  Fly   162 EDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDR--VNHKPILMTGPL-----NLTLVV------- 212
            ......|.|.:.|...|:.|.....|.:.|.|:  :|..|::.|...     |:.|:|
Human   279 SSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPK 343

  Fly   213 ---------------------NSTGSMHCKYLSDL-------TSKKAWIFVPCHGMTNCSNNRSI 249
                                 .|....:.:|:|:|       |....:.|:..:...|.:...::
Human   344 PEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNV 408

  Fly   250 IAEDKDQL----DFVNVRME---------QEGWYTCVESNSLGQSNSTAYLRV-VRSLHVLEAG- 299
            ....|.::    ..||..::         ...||.|..:.   |..|.:.|.| |::|:  .:|
Human   409 YVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTE---QRCSASVLPVDVQTLN--SSGP 468

  Fly   300 -----VASGSLHSTSFVYIFVFGGLI------FIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWT 353
                 |...|:.|::|.:    .|.:      .:..|:.:..:|.:....|:        :|..|
Human   469 PFGKLVVQSSIDSSAFKH----NGTVECKAYNDVGKTSAYFNFAFKGNNKEQ--------IHPHT 521

  Fly   354 KKVIIFKP--EGGGDSSGSMDTMIM---------PVVRIQKQRTTVLQNGNEPAPFNEYEFPLDS 407
                :|.|  .|....:|.|..::|         |:..:|.:....: |||.....:..:.|.|.
Human   522 ----LFTPLLIGFVIVAGMMCIIVMILTYKYLQKPMYEVQWKVVEEI-NGNNYVYIDPTQLPYDH 581

  Fly   408 NWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-------VAVKMVKEGHTDDDIASLVREMEVMK 465
            .||.||:.|..|.|||.||||:||.|.....|       |||||:|......:..:|:.|::|:.
Human   582 KWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLS 646

  Fly   466 IIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDF--------------------LYKNRPFGR 510
            .:|.|:||:||||.|:..||..||.||..:|:|.:|                    ||||....:
Human   647 YLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSK 711

  Fly   511 DQDRDSS-------QPPPSPPAHVITEK--------------------------------DLIKF 536
            :.....|       :|..|   :|:..|                                ||:.|
Human   712 ESSCSDSTNEYMDMKPGVS---YVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSF 773

  Fly   537 AHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMA 601
            ::|:|:||.:|||:.||||||||||:|::...:.||.||||||||::...|....|.|||:||||
Human   774 SYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMA 838

  Fly   602 PESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYIL 666
            |||:....|..:||||||||.|||:.:.|..|||.:....:.|..:..|.||..|......:|.:
Human   839 PESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDI 903

  Fly   667 MRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIAN 705
            |:.||..:...||.|.:||:.::|.:....:::..::||
Human   904 MKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLAN 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	19/89 (21%)
		IG_like	113..191	CDD:214653	18/88 (20%)
		IG_like	205..289	CDD:214653	19/136 (14%)
		PKc_like	404..692	CDD:304357	129/353 (37%)
		STYKc	416..688	CDD:214568	122/337 (36%)
KIT	NP_001372213.1	Ig strand A	212..215	CDD:409353
		ig	216..306	CDD:395002	21/91 (23%)
		Ig strand B	229..239	CDD:409353	2/10 (20%)
		Ig strand C'	250..252	CDD:409353	0/1 (0%)
		Ig strand D	260..263	CDD:409353	0/2 (0%)
		Ig strand E	267..280	CDD:409353	4/13 (31%)
		Ig strand F	287..294	CDD:409353	2/6 (33%)
		Ig strand G	300..308	CDD:409353	1/7 (14%)
		IgI_4_SCFR	312..412	CDD:409446	13/99 (13%)
		Ig strand B	332..336	CDD:409446	1/3 (33%)
		Ig strand C	346..350	CDD:409446	0/3 (0%)
		Ig strand E	376..380	CDD:409446	2/3 (67%)
		Ig strand F	390..395	CDD:409446	1/4 (25%)
		Ig strand G	403..406	CDD:409446	0/2 (0%)
		Ig	427..503	CDD:409353	16/84 (19%)
		Ig strand C	438..442	CDD:409353	0/3 (0%)
		Ig strand E	471..479	CDD:409353	1/7 (14%)
		Ig strand F	489..494	CDD:409353	0/4 (0%)
		PTKc_Kit	554..929	CDD:270682	133/378 (35%)
		Important for interaction with phosphotyrosine-binding proteins	569..571		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810