DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and KDR

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:844 Identity:233/844 - (27%)
Similarity:347/844 - (41%) Gaps:219/844 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WSWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRR----QMANSQEMIKDHLG-ARSQNKTPA 64
            |.|:.........|.:       :|:..|....|.|.    |..|..|:.|:... ...:|||.:
Human   458 WYWQLEEECANEPSQA-------VSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVS 515

  Fly    65 --ITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLN--- 124
              :...||.|:....:.        .||..           |..:.:||..||  |..:||.   
Human   516 TLVIQAANVSALYKCEA--------VNKVG-----------RGERVISFHVTR--GPEITLQPDM 559

  Fly   125 -----------CHALGNPEPNITWYRNGTVDWTRGYGSLKR-------NRWTLT----------- 160
                       |.|..:...|:|||:.|........|.|..       ..|.|.           
Human   560 QPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDI 624

  Fly   161 ----MEDLVPGDCGNYTCKVCNSLGCIRHDT--QVIVSDRVNHKPILMTGPL-NLTLVVNSTGSM 218
                :::....|.|:|.|...:.....||..  |:.|.:||  .|.: ||.| |.|..:..:..:
Human   625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERV--APTI-TGNLENQTTSIGESIEV 686

  Fly   219 HCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAED----KD---QLDFVNVRMEQEGWYTCVESN 276
            .|....:...:..|.          .:|.:::.:.    ||   .|....||.|.||.|||...:
Human   687 SCTASGNPPPQIMWF----------KDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACS 741

  Fly   277 SLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKV 341
            .||.:...|:.            :..|:...|:...|.:.|..:......|.:...:|.:|    
Human   742 VLGCAKVEAFF------------IIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVK---- 790

  Fly   342 LKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEY--EFP 404
                              :..||...:|.:..::.|                :..|.:|:  ..|
Human   791 ------------------RANGGELKTGYLSIVMDP----------------DELPLDEHCERLP 821

  Fly   405 LD-SNWELPRSHLVLGATLGEGAFGRVVMAE-------VNNAIVAVKMVKEGHTDDDIASLVREM 461
            .| |.||.||..|.||..||.||||:|:.|:       .....|||||:|||.|..:..:|:.|:
Human   822 YDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL 886

  Fly   462 EVMKIIGRHINIINLLGCCSQ-NGPLYVIVEYAPHGNLKDFLYKNR----PF---------GRD- 511
            :::..||.|:|::||||.|:: .|||.||||:...|||..:|...|    |:         |:| 
Human   887 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDY 951

  Fly   512 --------------------------------QDRDSSQPPPSPPAHVITEKDLIKFAHQIARGM 544
                                            .|.:..:.|.......:|.:.||.::.|:|:||
Human   952 VGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGM 1016

  Fly   545 DYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDI-QSTDYYRKNTNGRLPIKWMAPESLQEK 608
            ::||||:||||||||||:|:|:..|:||.|||||||| :..||.||. :.|||:||||||::.::
Human  1017 EFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDR 1080

  Fly   609 FYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHF 673
            .|..:|||||:|:|||||.:.|..|||.:...||....|..|.||..|...:..:|..|..|||.
Human  1081 VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHG 1145

  Fly   674 NADDRPPFTEIVEYMDKLLQTK-----EDYLDVDIA-----------NLDTPPSTSDEEEDETD 721
            ....||.|:|:||::..|||..     :||:.:.|:           :|.|.|.:..|||:..|
Human  1146 EPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCD 1209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 26/127 (20%)
Ig strand B 121..125 CDD:409353 2/17 (12%)
Ig strand C 134..138 CDD:409353 2/3 (67%)
Ig strand E 157..161 CDD:409353 2/18 (11%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 2/2 (100%)
Ig 200..289 CDD:472250 22/96 (23%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 2/6 (33%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 136/343 (40%)
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448
Ig strand A 224..228 CDD:409448
Ig strand A' 234..238 CDD:409448
Ig strand B 240..249 CDD:409448
Ig strand C 256..261 CDD:409448
Ig strand C' 264..266 CDD:409448
Ig strand D 270..278 CDD:409448
Ig strand E 286..294 CDD:409448
Ig strand F 304..310 CDD:409448
Ig strand G 315..321 CDD:409448
IgI_VEGFR-2 329..417 CDD:409450
Ig strand A 329..332 CDD:409450
Ig strand A' 339..343 CDD:409450
Ig strand B 345..356 CDD:409450
Ig strand C 360..366 CDD:409450
Ig strand C' 368..371 CDD:409450
Ig strand D 376..379 CDD:409450
Ig strand E 381..386 CDD:409450
Ig strand F 394..402 CDD:409450
Ig strand G 408..417 CDD:409450
IG_like 565..661 CDD:214653 18/95 (19%)
I-set 667..754 CDD:400151 23/109 (21%)
Ig strand B 684..688 CDD:409353 0/3 (0%)
Ig strand C 697..701 CDD:409353 0/3 (0%)
Ig strand E 720..724 CDD:409353 1/3 (33%)
Ig strand F 734..739 CDD:409353 3/4 (75%)
VEGFR-2_TMD 759..793 CDD:375470 6/55 (11%)
PTKc_VEGFR2 826..1167 CDD:270681 136/341 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
Blue background indicates that the domain is not in the aligned region.

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