DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and KDR

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:844 Identity:233/844 - (27%)
Similarity:347/844 - (41%) Gaps:219/844 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WSWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRR----QMANSQEMIKDHLG-ARSQNKTPA 64
            |.|:.........|.:       :|:..|....|.|.    |..|..|:.|:... ...:|||.:
Human   458 WYWQLEEECANEPSQA-------VSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVS 515

  Fly    65 --ITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLN--- 124
              :...||.|:....:.        .||..           |..:.:||..||  |..:||.   
Human   516 TLVIQAANVSALYKCEA--------VNKVG-----------RGERVISFHVTR--GPEITLQPDM 559

  Fly   125 -----------CHALGNPEPNITWYRNGTVDWTRGYGSLKR-------NRWTLT----------- 160
                       |.|..:...|:|||:.|........|.|..       ..|.|.           
Human   560 QPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDI 624

  Fly   161 ----MEDLVPGDCGNYTCKVCNSLGCIRHDT--QVIVSDRVNHKPILMTGPL-NLTLVVNSTGSM 218
                :::....|.|:|.|...:.....||..  |:.|.:||  .|.: ||.| |.|..:..:..:
Human   625 LIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERV--APTI-TGNLENQTTSIGESIEV 686

  Fly   219 HCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAED----KD---QLDFVNVRMEQEGWYTCVESN 276
            .|....:...:..|.          .:|.:::.:.    ||   .|....||.|.||.|||...:
Human   687 SCTASGNPPPQIMWF----------KDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACS 741

  Fly   277 SLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKV 341
            .||.:...|:.            :..|:...|:...|.:.|..:......|.:...:|.:|    
Human   742 VLGCAKVEAFF------------IIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVK---- 790

  Fly   342 LKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEY--EFP 404
                              :..||...:|.:..::.|                :..|.:|:  ..|
Human   791 ------------------RANGGELKTGYLSIVMDP----------------DELPLDEHCERLP 821

  Fly   405 LD-SNWELPRSHLVLGATLGEGAFGRVVMAE-------VNNAIVAVKMVKEGHTDDDIASLVREM 461
            .| |.||.||..|.||..||.||||:|:.|:       .....|||||:|||.|..:..:|:.|:
Human   822 YDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL 886

  Fly   462 EVMKIIGRHINIINLLGCCSQ-NGPLYVIVEYAPHGNLKDFLYKNR----PF---------GRD- 511
            :::..||.|:|::||||.|:: .|||.||||:...|||..:|...|    |:         |:| 
Human   887 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDY 951

  Fly   512 --------------------------------QDRDSSQPPPSPPAHVITEKDLIKFAHQIARGM 544
                                            .|.:..:.|.......:|.:.||.::.|:|:||
Human   952 VGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGM 1016

  Fly   545 DYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDI-QSTDYYRKNTNGRLPIKWMAPESLQEK 608
            ::||||:||||||||||:|:|:..|:||.|||||||| :..||.||. :.|||:||||||::.::
Human  1017 EFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDR 1080

  Fly   609 FYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHF 673
            .|..:|||||:|:|||||.:.|..|||.:...||....|..|.||..|...:..:|..|..|||.
Human  1081 VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHG 1145

  Fly   674 NADDRPPFTEIVEYMDKLLQTK-----EDYLDVDIA-----------NLDTPPSTSDEEEDETD 721
            ....||.|:|:||::..|||..     :||:.:.|:           :|.|.|.:..|||:..|
Human  1146 EPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCD 1209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 23/116 (20%)
IG_like 113..191 CDD:214653 23/115 (20%)
IG_like 205..289 CDD:214653 20/91 (22%)
PKc_like 404..692 CDD:304357 136/343 (40%)
STYKc 416..688 CDD:214568 129/326 (40%)
KDRNP_002244.1 Ig 41..109 CDD:299845
IG_like 231..324 CDD:214653
Ig1_VEGFR 239..326 CDD:143270
IG_like 340..417 CDD:214653
Ig2_VEGFR-2 348..417 CDD:143272
Ig_2 551..661 CDD:290606 20/109 (18%)
IG 565..661 CDD:214652 18/95 (19%)
I-set 667..754 CDD:254352 23/109 (21%)
IGc2 680..744 CDD:197706 14/73 (19%)
PTKc_VEGFR2 826..1167 CDD:270681 136/341 (40%)
Pkinase_Tyr 834..1160 CDD:285015 129/326 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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