DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Egfr

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_476759.1	Gene:	Egfr / 37455	FlyBaseID:	FBgn0003731	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	181/786 - (23%)
Similarity:	296/786 - (37%)	Gaps:	249/786 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RNPKKMSFLQTRPSGSLLTLN----CHALGNPEPNITW----------------------YRNGT 142
            ||.|::|      |||::..:    |:.     .||.|                      .:|||
  Fly   518 RNLKQIS------SGSVVIQHNRDLCYV-----SNIRWPAIQKEPEQKVWVNENLRADLCEKNGT 571

  Fly   143 V-------DWTRGYGSLKRNRWTLTMEDL-----VPGDCG---------NYTCKV-------CNS 179
            :       |...|.|:.:    .||.::.     ...|||         |.|||:       ||.
  Fly   572 ICSDQCNEDGCWGAGTDQ----CLTCKNFNFNGTCIADCGYISNAYKFDNRTCKICHPECRTCNG 632

  Fly   180 LG------CIR-HDTQVIVSD----RVNHKPIL---------MTGP-----------LNLTLVVN 213
            .|      |:. .|.|..||:    :.|.:.:.         .|||           .||.::.|
  Fly   633 AGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDGCTGPKDTIGIGACTTCNLAIINN 697

  Fly   214 STGSMHCKYLSD-LTSKKAWIFV------------------PCHGM----TNCSNNRSIIAE--- 252
            ......|....| ......|.:|                  .||.:    ||...:..:.::
  Fly   698 DATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTH 762

  Fly   253 -----------------DKDQLDFVNVRMEQEGW-------------YTCVESNSLG-QSNSTAY 286
                             |::|.:......|..|.             :...::|..| ..|||.:
  Fly   763 YKRREQCETECPADHYTDEEQRECFQCHPECNGCTGPGADDCKSCRNFKLFDANETGPYVNSTMF 827

  Fly   287 ---------LRVVRSLHVLEAGVASGSLHSTSFV-------YIFVFGGLIFIFMTTLFVFYAIRK 335
                     :|.|...:.......:.|...:|.:       .||:..|.:.:  .|:.:...:..
  Fly   828 NCTSKCPLEMRHVNYQYTAIGPYCAASPPRSSKITANLDVNMIFIITGAVLV--PTICILCVVTY 890

  Fly   336 MKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNE 400
            :..:| .|.:.|||                                  :.|..|....:..|..
  Fly   891 ICRQK-QKAKKETV----------------------------------KMTMALSGCEDSEPLR- 919

  Fly   401 YEFPLDSNWELPRSHLV------LGATLGEGAFGRVV----MAEVNNA--IVAVKMVKEGHTDDD 453
               |.:....|.:..:|      .|..||.||||||.    :.|..|.  .||:|.:.:....:.
  Fly   920 ---PSNIGANLCKLRIVKDAELRKGGVLGMGAFGRVYKGVWVPEGENVKIPVAIKELLKSTGAES 981

  Fly   454 IASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQ 518
            ....:||..:|..: .|:|::.||..| .:..:.:|.:..|.|.|.|::..||      |:
  Fly   982 SEEFLREAYIMASV-EHVNLLKLLAVC-MSSQMMLITQLMPLGCLLDYVRNNR------DK---- 1034

  Fly   519 PPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQS 583
                     |..|.|:.::.|||:||.||..:|.:|||||||||||....::||.|||||:.:.|
  Fly  1035 ---------IGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLSS 1090

  Fly   584 TDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLM 648
            .....|...|::||||:|.|.::.:.:.||||||::|:.:||::|:||:|:..| .|:::...:.
  Fly  1091 DSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENI-PAKDIPDLIE 1154

  Fly   649 SGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPS-T 712
            .|.::|:|..||::||..:..|||.:|..||.|.::.....:..:....||.:........|: |
  Fly  1155 VGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTRLPAYT 1219

  Fly   713 SDEEED 718
            |.:|:|
  Fly  1220 SQDEKD 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	28/139 (20%)
		IG_like	113..191	CDD:214653	28/138 (20%)
		IG_like	205..289	CDD:214653	21/160 (13%)
		PKc_like	404..692	CDD:304357	100/299 (33%)
		STYKc	416..688	CDD:214568	98/283 (35%)
Egfr	NP_476759.1	Recep_L_domain	419..547	CDD:279382	11/39 (28%)
		GF_recep_IV	572..684	CDD:291509	24/115 (21%)
		FU	573..>606	CDD:238021	5/36 (14%)
		FU	617..659	CDD:214589	12/41 (29%)
		FU	662..716	CDD:214589	8/53 (15%)
		FU	739..786	CDD:238021	6/46 (13%)
		FU	784..834	CDD:214589	7/49 (14%)
		PTKc_EGFR_like	930..1208	CDD:270648	100/299 (33%)
		STYKc	938..1194	CDD:214568	97/277 (35%)
		Recep_L_domain	128..239	CDD:279382
		Furin-like	253..401	CDD:279142
		FU	255..292	CDD:214589
		FU	302..345	CDD:238021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455233
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940