Protein Alignment htl and Epha2

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001102447.1
• Gene: Epha2 / 366492
• RGDID: 1307204
• Length: 977
• Species: Rattus norvegicus
• Alignment Length: 680
• Identity: 185/680 - (27%)
• Similarity: 285/680 - (41%)
• Gaps: 135/680 - (19%)

  Fly   102 YWRNPK-KMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWT--RGYGSLKRNRWTLTMED 163
            |:|.|: .:|...|||..:...|....:|         ....:.||  :..|..|...:::|.|.
  Rat   314 YFRAPEDPLSMPCTRPPSAPHYLTAIGMG---------AKVELRWTAPQDTGGRKDIVYSVTCEQ 369

  Fly   164 LVP--GDCGNYTCKVCNS---LGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYL 223
            ..|  |:||:....|..|   ....|  |.|.|||...|        :|.|..|.:...     :
  Rat   370 CWPESGECGSCEASVQYSEPPQALTR--TSVTVSDLEPH--------MNYTFTVEARNG-----V 419

  Fly   224 SDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDF-----VNVRMEQEGWYTCVESNSLGQSNS 283
            |||.:.::  |.......|.:....:..||:.....     :.|..:...|...|.....|.:||
  Rat   420 SDLVNSRS--FRTASVSINQTEPPKVRLEDRSTTSLSVAWSIPVPQQSRVWKYEVTYRKKGDANS 482

  Fly   284 -------------------TAYLRVVRSLHVLEAGVASGS-------LHSTSFVYIFVFGGLIFI 322
                               |.||..|::|  .:.|..:||       |.:.....:.|.|| :.:
  Rat   483 YNVHRTDGFSVTLDGLAPGTTYLVQVQAL--TQEGQGAGSKVHEFQTLSTEGSATMAVIGG-VAV 544

  Fly   323 FMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTT 387
            .:..|.|...|....|.   ::|.....|.::.|...|.|                 :::..:|.
  Rat   545 GVVLLLVLAGIGFFIHR---RRRNLRARQSSEDVYFSKSE-----------------QLKPLKTY 589

  Fly   388 VLQNGNEPAPFNEYEFP----LDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI------VAV 442
            |     :|   :.||.|    |....|:..|.:.....:|.|.||.|....:.::.      ||:
  Rat   590 V-----DP---HTYEDPNQAVLKFTTEIHPSCVSRQKVIGAGEFGEVYKGTLKSSSGKKEIPVAI 646

  Fly   443 KMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP 507
            |.:|.|:|:......:.|..:|.....| |||.|.|..|:..|:.:|.||..:|.|..||
  Rat   647 KTLKAGYTEKQRVDFLSEASIMGQFSHH-NIIRLEGVVSKYKPMMIITEYMENGALDKFL----- 705

  Fly   508 FGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKI 572
              |::|.:.|         |:   .|:.....||.||.|||:...:||||||||:||:.:.|.|:
  Rat   706 --REKDGEFS---------VL---QLVGMLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKV 756

  Fly   573 ADFGLARDIQSTDYYRKNTN-GRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPT 636
            :||||:|.::........|: |::||:|.|||::..:.:.|.||||||||::||:||||::|| .
  Rat   757 SDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMTYGERPY-W 820

  Fly   637 IMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDV 701
            .:|..|:...:..|.|:..|..|...||.||.|||......||.|.:||..:|||::..:..  .
  Rat   821 ELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERSRRPKFADIVSILDKLIRAPDSL--K 883

  Fly   702 DIANLDTP-----PSTSDEEEDETDNLQKW 726
            .:|:.|..     ||||..|......:.:|
  Rat   884 TLADFDPRVSIRLPSTSGSEGVPFRTVSEW 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	24/96 (25%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	19/112 (17%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	2/21 (10%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	106/298 (36%)
Epha2	NP_001102447.1	EphR_LBD_A2	27..200	CDD:198448
		fn3	331..419	CDD:394996	24/111 (22%)
		fn3	439..520	CDD:394996	14/82 (17%)
		EphA2_TM	<570..611	CDD:464211	12/65 (18%)
		Protein Kinases, catalytic domain	608..876	CDD:473864	104/288 (36%)
		SAM_EPH-A2	903..972	CDD:188942	2/11 (18%)