DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and fgfr2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_068081038.1 Gene:fgfr2 / 352940 ZFINID:ZDB-GENE-030323-1 Length:840 Species:Danio rerio


Alignment Length:757 Identity:286/757 - (37%)
Similarity:399/757 - (52%) Gaps:99/757 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 TMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMI--KDHLGARSQNK-------------TPA 64
            |.....:.|||.:    .|...::.:..::.:.:::  ||....|..|:             ||.
Zfish    64 TKNQNCVPVLFSV----HPGELLKLKCPLSGADDVVWTKDSSSLRPDNRTLVTRDWLQISDATPK 124

  Fly    65 ITNNANQSSTSSADLD------------DGAADDDDNKADLPVNVSSK----PYWRNPKKM-SFL 112
            .:...:.|:|.|.|.|            ....|:||.:....|....:    |||..|:|| ..|
Zfish   125 DSGLYSCSATGSRDCDVFSFIVNVTDAISSGDDEDDTERSDDVGADGEQMRLPYWTFPEKMEKKL 189

  Fly   113 QTRPSGSLLTLNCHALGNPEPNITWYRNG----TVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYT 173
            ...|:.:.:...|.|.|||:|.:.|.:|.    ..|...|| .::...|||.||.:||.|.||||
Zfish   190 HAVPAANTVKFRCAAAGNPKPKMRWLKNAKPFRQEDRMGGY-KVRLQHWTLIMESVVPSDKGNYT 253

  Fly   174 CKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPC 237
            |.|.|..|.|.|...:.|.:|..|:|||..| |.|:|:.|.......||..||......|:   .
Zfish   254 CLVENQYGSINHTYTLDVVERSPHRPILQAGLPANVTVQVGQDAKFVCKVYSDAQPHIQWL---Q 315

  Fly   238 HGMTNCS-------------NNRSIIAEDK--DQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYL 287
            |...|.|             ....:...||  :.|...||..|..|.|||:..||:|.|..||:|
Zfish   316 HYTKNGSRYGPDGLPYVRVLKTAGVNTTDKEIEVLYLPNVTFEDAGEYTCLAGNSIGISYHTAWL 380

  Fly   288 RVVRSLHVLEAGVASGSLHSTSF------VYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRI 346
            .|    |..|....     .|.:      :.|:..|..:...|..:.|...:|....:.....: 
Zfish   381 TV----HPAETNPI-----ETDYPPDYVEIAIYCIGVFLIACMVVIVVVCRMRTSAKKPDFSSQ- 435

  Fly   347 ETVHQWTKKVIIFKP-EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWE 410
            ..||:.||::.:.:. ....|||.||.:. .|:|||..:|::.   .::|.|  ||:.|.|..||
Zfish   436 PAVHKLTKQIPLRRQVTVSSDSSSSMSSS-TPLVRITTRRSSA---HDDPIP--EYDLPEDPRWE 494

  Fly   411 LPRSHLVLGATLGEGAFGRVVMAEV--------NNAI-VAVKMVKEGHTDDDIASLVREMEVMKI 466
            ..|..|.||..||||.||:|||||.        ..|: |||||:|:..|:.|::.||.|||:||:
Zfish   495 FSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM 559

  Fly   467 IGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEK 531
            ||||.|||||||.|:|:||||||||||..|||:::|...||.|.:...|.::....|    :|.|
Zfish   560 IGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDIARVSDEP----LTFK 620

  Fly   532 DLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLP 596
            ||:...:|:||||:||||::|||||||||||||::..|:||||||||||:.:.|||:|.||||||
Zfish   621 DLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVHNIDYYKKTTNGRLP 685

  Fly   597 IKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSM 661
            :||||||:|.::.|..:|||||:|:|:|||.|.|..|||.| ..|||:..|..|.||:|||.|:.
Zfish   686 VKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTN 749

  Fly   662 NIYILMRQCWHFNADDRPPFTEIVEYMDKL--LQTKEDYLDV 701
            .:|::|:.|||..:..||.|.::||.:|::  |.|.|:|||:
Zfish   750 ELYMMMKDCWHAISSHRPTFKQLVEDLDRILTLATNEEYLDL 791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 37/94 (39%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 3/3 (100%)
Ig strand F 171..176 CDD:409353 4/4 (100%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 32/104 (31%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 160/298 (54%)
fgfr2XP_068081038.1 Ig 56..148 CDD:472250 16/87 (18%)
Ig strand B 82..86 CDD:409353 0/3 (0%)
Ig strand E 114..118 CDD:409353 0/3 (0%)
Ig strand F 128..133 CDD:409353 0/4 (0%)
Ig strand G 141..144 CDD:409353 0/2 (0%)
IgI_2_FGFR 177..271 CDD:409443 37/94 (39%)
Ig strand A 177..180 CDD:409443 2/2 (100%)
Ig strand A' 188..193 CDD:409443 1/4 (25%)
Ig strand B 197..205 CDD:409443 1/7 (14%)
Ig strand C 211..216 CDD:409443 1/4 (25%)
Ig strand C' 219..221 CDD:409443 0/1 (0%)
Ig strand D 230..233 CDD:409443 1/3 (33%)
Ig strand E 237..242 CDD:409443 3/4 (75%)
Ig strand F 251..258 CDD:409443 5/6 (83%)
Ig strand G 261..271 CDD:409443 3/9 (33%)
IgI_3_FGFR2 279..383 CDD:409444 34/110 (31%)
Ig strand A 279..282 CDD:409444 2/2 (100%)
Ig strand A' 286..290 CDD:409444 2/3 (67%)
Ig strand B 298..305 CDD:409444 2/6 (33%)
Ig strand C 309..316 CDD:409444 1/9 (11%)
Ig strand D 331..336 CDD:409444 0/4 (0%)
Ig strand E 348..353 CDD:409444 1/4 (25%)
Ig strand F 361..369 CDD:409444 4/7 (57%)
Ig strand G 372..380 CDD:409444 4/7 (57%)
PTKc_FGFR2 475..787 CDD:270679 166/321 (52%)

Return to query results.
Submit another query.