DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and dnt

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster

Alignment Length:	283	Identity:	82/283 - (28%)
Similarity:	139/283 - (49%)	Gaps:	26/283 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 SNWELPRSHLVLGATLGEGAFGRVVMAEVNNA-IVAVKMVKEGHTDDDIASLVREMEVMKIIG-R 469
            |...:.|..:.|.:.|.||.||||.....|:. .|.||.|.:..:...:..|::  |.|.:.| .
  Fly   308 SELTVERCRVRLSSLLQEGTFGRVYRGTYNDTQDVLVKTVAQHASQMQVLLLLQ--EGMLLYGAS 370

  Fly   470 HINIINLLGCCSQNGPLYVIVEYAPHG--NLKDFLYKNRPFGRDQDRDSSQPPPSPP-AHVITEK 531
            |..|:::||...::.....::..|.:.  |||.||.                  .|. |..:|..
  Fly   371 HPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFLL------------------DPACARTVTTI 417

  Fly   532 DLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLP 596
            .::..|.|::..:|:|.|...:|:|:|.||.::.|...:|::|..|:||:..:||.....:...|
  Fly   418 QIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVKLSDSSLSRDLFPSDYNCLGDSENRP 482

  Fly   597 IKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSM 661
            :|||:.|:||.|.:...||.|::|:|:||:.|..:|||..: ...|:..||..|.|:.:|..|..
  Fly   483 VKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEV-DPFEMEHYLKDGYRLAQPFNCPD 546

  Fly   662 NIYILMRQCWHFNADDRPPFTEI 684
            .::.:|..||.....:||.|.::
  Fly   547 ELFTIMAYCWALLPAERPTFAQL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	82/283 (29%)
		STYKc	416..688	CDD:214568	80/274 (29%)
dnt	NP_001260567.1	WIF	46..182	CDD:128745
		PKc_like	310..580	CDD:304357	81/281 (29%)
		Pkinase_Tyr	317..573	CDD:285015	80/274 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940