DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and IGF1R

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_016877626.1 Gene:IGF1R / 3480 HGNCID:5465 Length:1392 Species:Homo sapiens


Alignment Length:503 Identity:151/503 - (30%)
Similarity:232/503 - (46%) Gaps:118/503 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 KDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYI----- 313
            :||.:.|: |.|... |...:.|.|...|.||.::.. ||.      .:||.....|.|:     
Human   899 EDQRECVS-RQEYRK-YGGAKLNRLNPGNYTARIQAT-SLS------GNGSWTDPVFFYVQAKTG 954

  Fly   314 ----------------FVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPE 362
                            .:.|||:.:    |:||:  ||..:.::                     
Human   955 YENFIHLIIALPVAVLLIVGGLVIM----LYVFH--RKRNNSRL--------------------- 992

  Fly   363 GGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAF 427
            |.|                      ||.....|..|:..:..:...||:.|..:.:...||:|:|
Human   993 GNG----------------------VLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSF 1035

  Fly   428 GRV-------VMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGP 485
            |.|       |:.:.....||:|.|.|..:..:....:.|..|||....| :::.|||..||..|
Human  1036 GMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQP 1099

  Fly   486 LYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASR 550
            ..||:|....|:||.:|...||   :.:.:....|||       ...:|:.|.:||.||.||.:.
Human  1100 TLVIMELMTRGDLKSYLRSLRP---EMENNPVLAPPS-------LSKMIQMAGEIADGMAYLNAN 1154

  Fly   551 RCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSD 615
            :.:||||||||.:|::|:.:||.|||:.|||..||||||...|.||::||:||||::..:.:.||
Human  1155 KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSD 1219

  Fly   616 VWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPP 680
            |||:|::||||.|..:|||.. :|.|::..::|.|..::||..|...::.|||.||.:|...||.
Human  1220 VWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPS 1283

  Fly   681 FTEIV----EYMD--------------KLLQTKEDYLDVDIANLDTPP 710
            |.||:    |.|:              ||.:.:|  ||::..|:::.|
Human  1284 FLEIISSIKEEMEPGFREVSFYYSEENKLPEPEE--LDLEPENMESVP 1329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 11/34 (32%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353 2/3 (67%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 114/312 (37%)
IGF1RXP_016877626.1 Recep_L_domain 76..186 CDD:460032
Furin-like 200..355 CDD:395614
Recep_L_domain 377..492 CDD:460032
FN3 519..631 CDD:238020
FN3 636..>680 CDD:238020
FN3 860..949 CDD:238020 16/58 (28%)
PTKc_InsR_like 1017..1293 CDD:173625 111/287 (39%)
Blue background indicates that the domain is not in the aligned region.

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