DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Pvr

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster

Alignment Length:	814	Identity:	222/814 - (27%)
Similarity:	320/814 - (39%)	Gaps:	263/814 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 KMSFLQTRPSGSLLTLNCHA------------------LGNPEPNITWY---------RNGTVDW 145
            ::|||.|.|.    .|.|.|                  |||...|:|.|         :...|::
  Fly   616 EVSFLPTEPG----ILTCIAQNIIDGKERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNF 676

  Fly   146 T---RGY---GSLKRNRWTLTMEDLVPGDC--------------------------GNYTCKVCN 178
            |   ..|   |:||   |.:..|||...|.                          |.|.|:
  Fly   677 TCEALAYHFDGNLK---WFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECR--- 735

  Fly   179 SLGCIRHDTQVIVSDR----VNHKPIL-------MTGPLNLTLVVNSTGSMHCKYLSDLTSKKAW 232
               ...:|...:.|.|    ..|.|..       ..|...:...::.|..:.|...:...:...|
  Fly   736 ---AYHNDKDAVYSSREIDLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAIVRW 797

  Fly   233 IFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLE 297
             |.....:|. |..|.|| |.:.:|...::....||.|.||..|.|.        |:.||..|:
  Fly   798 -FKDDKEVTE-SKLRHII-EKESKLLITHLYPGDEGVYKCVVENRLD--------RIERSFTVV- 850

  Fly   298 AGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPE 362
                ...|...|..::: ||.::|:.:..|.||.|:|..|..              |:.:..|..
  Fly   851 ----ISDLPGISMAWVW-FGVILFLILIGLCVFLAVRYQKEH--------------KRHLALKAA 896

  Fly   363 GGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFN-EYEFPLDSNWELPRSHLVLGATLGEGA 426
            |..:........|.|.:.:.:|.        |..|:| |:||        ||.:|.||..||.||
  Fly   897 GLANFEEGAVGHINPDLTLDEQA--------ELLPYNREFEF--------PRENLKLGKQLGAGA 945

  Fly   427 FGRVVMAEVN-------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQN- 483
            ||.|:..|..       ...|||||||....::.:.:||.|:::|..:|:|:|::||||..::|
  Fly   946 FGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNI 1010

  Fly   484 --GPLYVIVEYAPHGNLKDFLYKNR-----PFGRDQD------------------RD-------- 515
              ..|.|||||...||:::||.:||     ....|.|                  ||
  Fly  1011 AKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKY 1075

  Fly   516 -----------------SSQPP------------------------------------------- 520
                             ::|||
  Fly  1076 ANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVP 1140

  Fly   521 ---------------------PSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLV 564
                                 .|..|..:|..|||.:|.|:|||||||:|::.:|.||||||:|:
  Fly  1141 EDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILL 1205

  Fly   565 SDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTY 629
            .:|.|:||.||||||.:...|.|:|:.||:|||||:|.|||.:..:.:.||||||||:|||:.:.
  Fly  1206 CEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSL 1270

  Fly   630 GQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLL-- 692
            .:.|||.|...:||:..|..|.|||||...:..:|.:|.:||..|.:.||.|.|:.:....:|
  Fly  1271 AKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGE 1335

  Fly   693 QTKEDYLDVDIANLDTPPSTSDEE---EDETDNL 723
            .....|||     |:.|...|:.|   :..||.|
  Fly  1336 DVASHYLD-----LNNPYMQSNIEYMKKQSTDYL 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	27/137 (20%)
		IG_like	113..191	CDD:214653	26/136 (19%)
		IG_like	205..289	CDD:214653	18/83 (22%)
		PKc_like	404..692	CDD:304357	132/409 (32%)
		STYKc	416..688	CDD:214568	130/393 (33%)
Pvr	NP_001162911.1	IG	346..432	CDD:214652
		Ig	<363..432	CDD:299845
		Ig	466..533	CDD:299845
		IG_like	672..754	CDD:214653	17/90 (19%)
		Ig	674..739	CDD:143165	14/73 (19%)
		IGc2	779..840	CDD:197706	17/63 (27%)
		PKc_like	927..1332	CDD:304357	135/412 (33%)
		Pkinase_Tyr	935..1329	CDD:285015	130/393 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840