DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and CG3277

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	219/902 - (24%)
Similarity:	334/902 - (37%)	Gaps:	311/902 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 HSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSSTS 75
            |||   ...|.:||.|||.:.:.||. :..|:.|.:..:|.   ..||..|.|
  Fly     3 HST---KVPSRIVLILLLVLVRNAVG-QAPRENATNPTLIS---LVRSSEKEP------------ 48

  Fly    76 SADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRN 140
                       :..::...|...|:|....|.....|...|.|.:..|.        .|:|.|..
  Fly    49 -----------EQMESHRYVTGLSEPIAMEPLTRMRLNPNPDGEITELT--------TNVTLYME 94

  Fly   141 GTVDWTRGYGSLKRNRWTLTMEDLVP-GDCGNYTCKVCNSLGC---------IRHDTQVIVSDRV 195
                        |..|..:..:|.:| |...|......|:..|         |:.......:..|
  Fly    95 ------------KIPRLQVRWQDNLPQGTSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSV 147

  Fly   196 NHKPILMTGPLNLTLVVNSTGSMHCKYL------------SDLTSKKAWIFVP-C-HGMTNC--- 243
            |.       |:|..|.|.   |:.|.|:            :.:..:.|.:::| | .|..:|
  Fly   148 NL-------PVNPNLNVE---SVDCNYMFGCQYQVIVETSNAMVRRSARVYIPQCLEGKCSCQLA 202

  Fly   244 ------------------SNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVV 290
                              |.|.||:|.:.       :|.||:
  Fly   203 PTPPKVLAVAKMLSNETISINLSILASEL-------LRKEQD----------------------- 237

  Fly   291 RSLHVLEAGVASGSLHSTSFVY------------IFVFGGLIFIFMTTLFV------------FY 331
                        ..||.|...|            ...:||::...||.::.            |.
  Fly   238 ------------SHLHETLRTYKMQLKINEETNPSLPWGGVLKHLMTRVYKLSELNFRATPKGFE 290

  Fly   332 AIRKMKHEKVLKQRIETVHQWTKKVIIFKPEG--------------------GGDS-SGSMDTM- 374
            .:.|:.....||::...    :.:.:|..|.|                    .||| |.|:..|
  Fly   291 GVMKLGLGTQLKEKASL----SLQAVIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMS 351

  Fly   375 -----------IMPVVRIQKQRTTVLQNGNEP---APFNEYEFPLDSN----------------- 408
                       ||.::|.::.|||......|.   ..|......::.|
  Fly   352 AMLIAIILAGLIMLLLRRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVNYVDKYVEKSQVLGLA 416

  Fly   409 --WELPRSHLVLGATLGEGAFGRVVMAEVNN-------AIVAVKMVKEGHTDDDIASLVREMEVM 464
              :|:|.|.:.:|..|||||||:|..|...|       .|||||.:|.....|::|..:.|:|::
  Fly   417 DIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEML 481

  Fly   465 KIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFL----------------YKN-RPFGRDQ 512
            |.:|.|.|:::.||||:...|..:|:||...|||..:|                |.: ||.....
  Fly   482 KGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCRPIMTRT 546

  Fly   513 DRDSS---------------------------------QPPPS-------------PPAHVITEK 531
            :..||                                 ||.||             ...:::..|
  Fly   547 NSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFEYILDNK 611

  Fly   532 DLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLP 596
            :|..||.|||.||.:|..:...||||||||||:..:..|||:||||:|.    ..|......:||
  Fly   612 ELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRH----GIYTNTRTRKLP 672

  Fly   597 IKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSM 661
            ::|::.|:::|..|.||||:|:||::||||.|.|..||||| |.:||..:||:|.|:|:|..|:.
  Fly   673 LRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTI-SNDELIPFLMAGNRLERPEICTP 736

  Fly   662 NIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLD--TPPSTSDEE 716
            .:|.:|.|||....::||.|    :.:.|:|..|..|:|::..:.|  .||.:.:.|
  Fly   737 QVYTIMLQCWLEEPEERPTF----DALYKVLSPKTTYVDINSLSDDYVFPPISENRE 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	16/88 (18%)
		IG_like	113..191	CDD:214653	15/87 (17%)
		IG_like	205..289	CDD:214653	20/118 (17%)
		PKc_like	404..692	CDD:304357	122/376 (32%)
		STYKc	416..688	CDD:214568	117/341 (34%)
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	118/345 (34%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	117/341 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455229
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840