Protein Alignment htl and tor

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_061502652.1
• Gene: tor / 3290041
• VectorBaseID: AGAMI1_007799
• Length: 1147
• Species: Anopheles gambiae
• Alignment Length: 1021
• Identity: 230/1021 - (22%)
• Similarity: 355/1021 - (34%)
• Gaps: 371/1021 - (36%)

  Fly    36 QVEGRRQMANSQEMIKDHLGARSQNKTPA--------ITNNANQSSTSSADL------------- 79
            |:...|..:.|.|.::....|||:....|        :|.....||.:..:|
Mosquito   155 QLNALRDRSASAESLESAAPARSRRAIGADGPLSAGQLTERQKASSGTRTNLLQPTAGKIDGPTL 219

  Fly    80 ---DDGAADDDDNKADLPVNVS-SKPYWRNPKKMSFLQTRPS---------------GSLLTLNC 125
               .|.:||:||...::.|.|. .:.:::........:|||.               |..:....
Mosquito   220 HGSVDASADEDDEADNVAVKVQPDREHYQRALAAEQDRTRPPVPIYLVKVQDSEQELGDRIVYMS 284

  Fly   126 HA----LGNPEPNITWYRNGTVDWTR-GYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRH 185
            :|    :.|..||..:....|:..:. .|..::::::.....|.:||        :...:...|.
Mosquito   285 NASLVKIENLAPNRRYNVTATMLTSEYEYYYVEKHQYRTLPHDYMPG--------IVTDIMVERF 341

  Fly   186 DT--------QVIVS-----DRVNH---------------KPILMTGPLNLTLVVNSTGSMHCKY 222
            :|        ..::|     ||..|               |||.:..|..|.........:...|
Mosquito   342 ETNARDSRLVDAVISWTPAKDRTCHYEIVCHASYSPDFLLKPIDVQQPEVLYKYTIKALKLSANY 406

  Fly   223 LSDLTSKKA----------W----------------------------IFVPCHG---MTNCSNN 246
            :..:.||..          |                            ..||.:|   ..|.|.:
Mosquito   407 MIAVRSKNTQNAMRESQLHWQSFHTPSCTNHTNGTQVCAPEPITNVRVTQVPLYGDHYQLNISWD 471

  Fly   247 RSIIAEDK---DQLDFVNVRMEQEGWYTCVESNSLGQSNS-----------------TAYLRV-- 289
            |..||.|.   ...|..|...|:.|  ..|..|..|.:..                 .||.||
Mosquito   472 RPTIAPDSYVVKVFDLHNPETEEPG--NSVTKNLTGDAVGVLIESFEMFGPHFEVLVAAYSRVGV 534

  Fly   290 --VRSLHVLEAG-VASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQ 351
              ..::..|:.| |:|.|...|..|:| :...::.|.:..:.:....|:....|..::|.|...:
Mosquito   535 SSENTIKALQIGRVSSESWIRTKLVFI-ILTPVLMIGLLKISISLICRRRAKLKRYEERCEYFKE 598

  Fly   352 WTKKVII-----FKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFN-EYEFPLDSNWE 410
            ..:|..:     |:|                   ..||...:|...:   ||: :...|::...|
Mosquito   599 LEQKAPVDPSTEFEP-------------------TSKQMQDLLATSH---PFSPDLIAPINDELE 641

  Fly   411 LPRSHLVLGATLGEGAFGRVVMAEVNNA--------IVAVKMVKEGHTDDDIASLVREMEVMKII 467
            :...|:.|...|||||||.|....:..:        .|||||:||....:||....|||||||.:
Mosquito   642 IEMEHIKLHDMLGEGAFGLVRKGVLQRSGDDGEPAQPVAVKMLKECPRVEDILEFRREMEVMKSV 706

  Fly   468 GRHINIINLLGCCSQN-GPLYVIVEYAPHGNLKDF--------LYKNRPFGRDQDRDSS------ 517
            |.|.:|:.::|.|::| ..:.::.||...|||.::        |.:||..|......:|
Mosquito   707 GTHPHIVGIVGHCTKNVRKMMLLTEYCGRGNLLNYLRLQWQRLLRQNRTTGTRSIGGTSGTNITA 771

  Fly   518 ------QPPPSPPAHVITEKD-------------------------------------------- 532
                  .|||.||...:...|
Mosquito   772 TLPSPPPPPPPPPTRSLEMADHECLTPSLDNNKMPENVFNFDTSFVNDKKSLTYKNISDHRQTLL 836

  Fly   533 ----------------------------------------------------------------- 532
                                                                             
Mosquito   837 GVAFGLAGGSDGSSASRSPQIIENKLYPLFSDESDGDETAQLTHCTNACKNAVEIVEGTWEVGED 901

  Fly   533 --------------------------------------------------LIKFAHQIARGMDYL 547
                                                              |::|:.|||.||::|
Mosquito   902 VKGSVRIKPCSCHGAPVDSTLTNNTVENRWYQSCSPQSEEEEDPLPNSGQLLEFSRQIALGMEFL 966

  Fly   548 ASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDS 612
            |..:.:|||||||||||.|...:|||||||:|||...:.|||.:||:|||||:|.||:..:.|.|
Mosquito   967 ARNKVVHRDLAARNVLVCDSNTVKIADFGLSRDIYQENLYRKTSNGKLPIKWLALESMTHQVYTS 1031

  Fly   613 KSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADD 677
            :||||||||||:||.|.|..|||.| |...|..||.||.|||:|..||..:|.||..||:.:..:
Mosquito  1032 QSDVWSYGILLYEICTLGGSPYPAI-STNRLLRYLESGYRMERPKSCSELLYDLMYSCWNLHPGE 1095

  Fly   678 RPPFTEIVEYMDKLLQTKE---DYLDVDIANLDTPPSTSDEEEDET 720
            ||.|::||..::: ||.::   |.:.:|::.:.....|.:..|:.:
Mosquito  1096 RPTFSKIVHTVEQ-LQARDIANDPVVIDLSAIVDSHCTKNTTEENS 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	15/117 (13%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	25/149 (17%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	2/41 (5%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	0/4 (0%)
		Ig strand G	282..285	CDD:409353	0/19 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	136/475 (29%)
tor	XP_061502652.1	None