DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and styk1b

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001292494.1	Gene:	styk1b / 324714	ZFINID:	ZDB-GENE-030131-3435	Length:	447	Species:	Danio rerio

Alignment Length:	344	Identity:	91/344 - (26%)
Similarity:	148/344 - (43%)	Gaps:	66/344 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 IQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMV 445
            :.:||.....||..|.|.: |....||...|.|                   |.:.|..|.::::
Zfish   134 LPRQRLPENFNGVAPLPAS-YSLKSDSPISLYR-------------------ARMENRNVVLRVL 178

  Fly   446 KEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR---- 506
            |:..::.:..|.:.....:..:|.|..:..|||..|...||..::|...:.:|..||::.|
Zfish   179 KDSASNQESQSFLGFAAFLSQLGPHPFLPELLGVISLRAPLITVIEEMENRDLLGFLWRCRQDNV 243

  Fly   507 -PFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVS----- 565
             |.|..|               :|||.:...|..:|..:|:|..:...|.:|.|||||||
Zfish   244 GPDGMCQ---------------MTEKKIFNMASHVASALDFLHGKDLHHCNLKARNVLVSRICTA 293

  Fly   566 -----DDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWE 625
                 ||..::.:..|    ..|.|..||        ||.|||.|.::....|||:||:|:||:|
Zfish   294 KLWGLDDLYVRTSGSG----NYSEDPGRK--------KWQAPELLAKRPSTPKSDIWSFGLLLYE 346

  Fly   626 IMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK 690
            ::|.|:.|:..| ..:||..:....:.:.||..||.::|.:::.|.|:...|||...|:   ..|
Zfish   347 MVTLGEVPFAEI-PVKELLQHHQRVKPIRKPNNCSNSLYSIIKSCCHWKEQDRPSLAEV---RRK 407

  Fly   691 LLQTKEDYLDVDIANLDTP 709
            |...::...|..:..:..|
Zfish   408 LQSGEKSASDSSVLRVPEP 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	81/302 (27%)
		STYKc	416..688	CDD:214568	76/286 (27%)
styk1b	NP_001292494.1	PKc_like	164..409	CDD:304357	78/294 (27%)
styk1b	NP_001292494.1	Pkinase_Tyr	164..408	CDD:285015	77/293 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810