DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Ephb2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_038965983.1 Gene:Ephb2 / 313633 RGDID:1564232 Length:988 Species:Rattus norvegicus


Alignment Length:760 Identity:178/760 - (23%)
Similarity:296/760 - (38%) Gaps:200/760 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 ANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKK 108
            ||..:....|....|:..:...||...::....||||         ..|:|...           
  Rat   279 ANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLD---------PLDMPCTT----------- 323

  Fly   109 MSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYT 173
               :.:.|...:.::|..:|             .::||....|..|       ||||    .|..
  Rat   324 ---IPSAPQAVISSVNETSL-------------MLEWTPPRDSGGR-------EDLV----YNII 361

  Fly   174 CKVCNS--LGCIRHDTQVIVSDRVNHKPILMTGPLNLT--------LVVNSTGSMHCKYLSDLTS 228
            ||.|.|  ..|.|      ..|.|.:.|    ..|.||        |:.::..:...:.::.:|.
  Rat   362 CKSCGSGRGACTR------CGDNVQYAP----RQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTD 416

  Fly   229 KKAWIFVPCHGMTNCSNNR------SIIAEDKDQLDFVNVRMEQEG------------WYTCVES 275
            :..  |.|.....|.:.|:      ||:.:....:|.:.:...|..            :|   |.
  Rat   417 QSP--FSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYY---EK 476

  Fly   276 NSLGQSNSTA------------------YLRVVRSLHVLEAGVASGSLHSTSFVYI--------- 313
            ..|.:.|:||                  |:..||:..|...|..||.::..:....         
  Rat   477 QELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIKEK 541

  Fly   314 --FVFG----GLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMD 372
              .:.|    |::|:....:......|:...|:...:..:.:..:|              ||.| 
  Rat   542 LPLIVGSSAAGVVFVIAVVVIAIVCNRRRGFERADSEYTDKLQHYT--------------SGHM- 591

  Fly   373 TMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPR----SHLVLGATLGEGAFGRVVMA 433
               .|.::|...            ||. ||.|.::..|..:    |.:.:...:|.|.||.|...
  Rat   592 ---TPGMKIYID------------PFT-YEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSG 640

  Fly   434 EV-----NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR--HINIINLLGCCSQNGPLYVIVE 491
            .:     ....||:|.:|.|:|:......:.|..:|   |:  |.|:|:|.|..:::.|:.:|.|
  Rat   641 HLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIM---GQFDHPNVIHLEGVVTKSTPVMIITE 702

  Fly   492 YAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRD 556
            :..:|:|..||.:|         |..          .|...|:.....||.||.|||....:|||
  Rat   703 FMENGSLDSFLRQN---------DGQ----------FTVIQLVGMLRGIAAGMKYLADMNYVHRD 748

  Fly   557 LAARNVLVSDDYVLKIADFGLAR---DIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWS 618
            |||||:||:.:.|.|::||||:|   |..|...|.....|::||:|.|||::|.:.:.|.|||||
  Rat   749 LAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWS 813

  Fly   619 YGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTE 683
            |||::||:|:||::|| ..|:.:::...:....|:..|..|...::.||..||..:.:.||.|.:
  Rat   814 YGIVMWEVMSYGERPY-WDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQ 877

  Fly   684 IVEYMDKLLQTKEDY---------LDVDIANLDTPPSTSDEEEDE 719
            ||..:||:::.....         :::.:.:...|..||....||
  Rat   878 IVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDE 922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 18/91 (20%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 20/132 (15%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 99/301 (33%)
Ephb2XP_038965983.1 EphR_LBD_B2 19..196 CDD:198445
fn3 326..421 CDD:394996 26/130 (20%)
fn3 437..521 CDD:394996 15/86 (17%)
EphA2_TM <566..619 CDD:464211 14/83 (17%)
PTKc_EphR_B 618..886 CDD:173638 97/290 (33%)
SAM_EPH-B2 912..982 CDD:188951 5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

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