Protein Alignment htl and Map3k10

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001382027.1
• Gene: Map3k10 / 308463
• RGDID: 1308381
• Length: 940
• Species: Rattus norvegicus
• Alignment Length: 355
• Identity: 106/355 - (29%)
• Similarity: 162/355 - (45%)
• Gaps: 61/355 - (17%)

  Fly   395 PAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVR 459
            ||...:.:.|    .|:|...|.|...:|.|.||:|..|......||||..:.....|...:..:
  Rat    81 PAAPTDLQLP----QEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERDPAVTAEQ 141

  Fly   460 EMEVMKIIG--RHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPS 522
            ..:..::.|  :|.|||.|.|.|.....|.:::|||..|.|...|...|
  Rat   142 VRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRR---------------- 190

  Fly   523 PPAHVITEKDLIKFAHQIARGMDYL---ASRRCIHRDLAARNVLVSD--------DYVLKIADFG 576
            .|.||     |:.:|.|:||||:||   |....|||||.:.|:|:.:        |.||||.|||
  Rat   191 VPPHV-----LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFG 250

  Fly   577 LARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAE 641
            |||:...|.  :.:..|  ...|||||.::...:...|||||:|:||||::| |:.||..|.:..
  Rat   251 LAREWHKTT--KMSAAG--TYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREIDALA 310

  Fly   642 ELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQT------------ 694
            ..|...|:...:..|:.|......|:.:||..:...||.|..|::.::.:.|:
  Rat   311 VAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHS 375

  Fly   695 -KEDYLDVDIANLDTPPSTSDEE----EDE 719
             :||: .::|.::.....|.::|    |:|
  Rat   376 LQEDW-KLEIQHMFDDLRTKEKELRSREEE 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	96/300 (32%)
Map3k10	NP_001382027.1	SH3_MLK1-3	20..76	CDD:212992
		Protein Kinases, catalytic domain	103..360	CDD:473864	91/282 (32%)
		Leucine-zipper 1	384..405		5/21 (24%)
		Leucine-zipper 2	419..440
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	490..599
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..658
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	687..732
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	748..916