DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and tek

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_009299388.1 Gene:tek / 30747 ZFINID:ZDB-GENE-990415-56 Length:1117 Species:Danio rerio


Alignment Length:777 Identity:206/777 - (26%)
Similarity:329/777 - (42%) Gaps:226/777 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 SGSLLTLNCHALGNPEP---NITWYRNGTVDWTRGYGSLKRNRWTL------TMED--------- 163
            :|..|::||.|.|.|.|   :||              .:..||.|:      |:.|         
Zfish   360 TGVELSVNCSASGRPAPLHGDIT--------------LITANRTTIAAVDTHTLNDQSTSVFRVQ 410

  Fly   164 -LVPGDCGNYTCKVCNSLGCIRHD--TQVIVSDRVNHKPILM-TGPLNLTLVVNSTGSMHCKYLS 224
             :.....|.:.|:|.|:...:..:  .:|.|..|..:.|:|. :||.:|.|::|:.     .|..
Zfish   411 QVRVSSAGRWRCQVNNTHAQVEDEFTVEVKVPPRPQNPPVLQGSGPRHLLLLLNTE-----PYSG 470

  Fly   225 D-----------LTSKKAWIFVPCHG--------------MTNCSNNR----------------- 247
            |           ..|...|.....||              :|....:|                 
Zfish   471 DGPIATTTLLYRPASAHTWSSFTAHGPLVRLDNLYPMTQYLTQVQLSRPGPGGAGQAGPAATFST 535

  Fly   248 -----------SIIAEDKDQLDFVNVRMEQEGWY--TCVESNSLG-------QSNSTA-YLRVVR 291
                       |.:::....|.:.....||...|  :|:::.:.|       .|||:| :|..::
Zfish   536 QVLELPVGVKLSAVSQTALLLSWDIAPAEQHCTYEVSCLQAGAPGTLRTFQLPSNSSAMHLSDLK 600

  Fly   292 SLHVLEAGVAS----GSLHSTSFVY-------------IFVFGGLIFIFMTTLFVFYAIRK---- 335
            ..|..:..|.|    |..|.::..:             |.::.    |..|:..:.:|:.:    
Zfish   601 PRHKYQCTVRSSCGVGQNHPSASAWTLSDPELPPPPANISIWN----ISDTSAVLTWAVAEGESV 661

  Fly   336 ----MKHEKV----LKQRIETVHQWTK-----KVIIFKPEGG-----------GDSSGSMDTMIM 376
                ::.::|    .:|::|...|..:     :::..:|..|           |:|:.|....:|
Zfish   662 SRAVIRFQQVEQAQYRQQVELPVQTQQLHMRFQLLGLRPNTGYQLQLWTVNNMGESAESPPVSLM 726

  Fly   377 PV------------------------------------VRIQKQRTTVLQN-----GNEPA-PFN 399
            .:                                    :.:|.:|.|:.:.     ..||| .|:
Zfish   727 TLPQQESSALFAAHGHLLLYAILGSAGMTCCTVLLAFCIVLQLKRNTLQRRIHSILREEPAVHFS 791

  Fly   400 EYEFPLDSNWELPRSHLVLGA----------TLGEGAFGRVVMAEVN----NAIVAVKMVKEGHT 450
            ....|...:..:.|| ||..|          .||||.||:|:.|.:.    ....|||.:|:..:
Zfish   792 SAPPPHRRSAVVSRS-LVFPALQWSDIQFQDVLGEGNFGQVLKARIRKDGLRMDAAVKRMKDYAS 855

  Fly   451 DDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRD 515
            .||......|:||:..:|.|.|||:|||.|...|.||:.:|:||||||.|||.|:|....|    
Zfish   856 QDDHRDFAGELEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETD---- 916

  Fly   516 SSQPPPSPPAH----VITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFG 576
                |....||    .::.:.|:.|:..:||||.||:.::.||||||||||||.:::|.||||||
Zfish   917 ----PAFAIAHRTASTLSSQQLLAFSADVARGMSYLSQKQFIHRDLAARNVLVGENFVAKIADFG 977

  Fly   577 LARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAE 641
            |:|   ..:.|.|.|.||||::|||.|||....|.:.|||||||:||||:::.|..|| ..|:..
Zfish   978 LSR---GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTPY-CGMTCA 1038

  Fly   642 ELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI 703
            |||..|..|.|:|||..|...:|.||:|||.....:||.|::|:..:.::|:.::.|::..:
Zfish  1039 ELYEKLPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQILLSLGRMLEERKTYVNTTL 1100

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 20/94 (21%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 2/3 (67%)
Ig strand E 157..161 CDD:409353 1/9 (11%)
Ig strand F 171..176 CDD:409353 1/4 (25%)
Ig strand G 184..187 CDD:409353 0/4 (0%)
Ig 200..289 CDD:472250 26/152 (17%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/6 (33%)
Ig strand G 282..285 CDD:409353 2/2 (100%)
Protein Kinases, catalytic domain 404..692 CDD:473864 129/305 (42%)
tekXP_009299388.1 Ig_Tie2_1 25..121 CDD:463089
EGF_CA <231..255 CDD:238011
Ig 348..437 CDD:472250 19/90 (21%)
Ig strand B 364..368 CDD:409353 1/3 (33%)
Ig strand C 380..384 CDD:409353 2/17 (12%)
Ig strand E 405..409 CDD:409353 0/3 (0%)
Ig strand F 419..424 CDD:409353 1/4 (25%)
Ig strand G 432..435 CDD:409353 0/2 (0%)
fn3 541..621 CDD:394996 17/79 (22%)
FN3 633..717 CDD:214495 11/87 (13%)
PTKc_Tie2 809..1111 CDD:133219 126/304 (41%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.