Protein Alignment htl and tie1

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_001334673.5
• Gene: tie1 / 30746
• ZFINID: ZDB-GENE-990415-55
• Length: 1122
• Species: Danio rerio
• Alignment Length: 463
• Identity: 167/463 - (36%)
• Similarity: 245/463 - (52%)
• Gaps: 69/463 - (14%)

  Fly   269 WYTCVESNSLGQSNST---AYLRVVRSL---HVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTL 327
            |.:.|::.:.|:..|:   ...:|.|.|   |.|...|. ||:..|          .:.|.:..|
Zfish   712 WSSFVQAQTPGEGLSSFIPTTQQVGRPLAEDHQLLFAVV-GSVAVT----------CVTILLALL 765

  Fly   328 FVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNG 392
            .:|| |||    .|||:|....:|                |||.:..|:..    ...|..|...
Zfish   766 ALFY-IRK----SVLKRRRTFTYQ----------------SGSGEETILQF----NSGTLTLTRR 805

  Fly   393 NEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN----NAIVAVKMVKEGHTDDD 453
            .:|:| ....:|: ..||    .:.....:|||.||:|:.|.|.    ....|:||:||..:::|
Zfish   806 PKPSP-EPLTYPI-LEWE----DIKFEDVIGEGNFGQVIKAMVKKDGIKMSAAIKMLKEFASEND 864

  Fly   454 IASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQ 518
            ......|:||:..:|:|.|||||:|.|...|.||:.:||||:|||.|||.|:|..    :.|.:.
Zfish   865 HRDFAGELEVLCKLGQHTNIINLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVL----ETDPAF 925

  Fly   519 PPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQS 583
            ......|..:|.:.|::||..:|.||.||:.::.||||||||||||.|:.|.|||||||:|   .
Zfish   926 AKEHGTASTLTSQQLLQFAADVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSR---G 987

  Fly   584 TDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLM 648
            .:.|.|.|.||||::|||.|||....|.:||||||:|:|||||::.|..|| ..|:..|||..|.
Zfish   988 EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPY-CGMTCAELYEKLP 1051

  Fly   649 SGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI------ANLD 707
            .|.|||:|..|...:|.||||||.....:||||::|...::::.:.::.|:::.:      |.:|
Zfish  1052 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFSQISVQLNRMQEARKAYVNMALFENFTYAGID 1116

  Fly   708 TPPSTSDE 715
               :|::|
Zfish  1117 ---ATAEE 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250	4/22 (18%)
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	1/5 (20%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	129/291 (44%)
tie1	XP_001334673.5	EGF_CA	<219..244	CDD:238011
		Ig	339..429	CDD:472250
		Ig strand B	356..360	CDD:409556
		Ig strand C	372..376	CDD:409556
		Ig strand E	397..401	CDD:409556
		Ig strand F	411..416	CDD:409556
		Ig strand G	424..427	CDD:409556
		FN3	<427..>774	CDD:442628	20/77 (26%)
		FN3	628..720	CDD:238020	2/7 (29%)
		Protein Kinases, catalytic domain	820..1116	CDD:473864	130/307 (42%)