DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and tyro3

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_571507.2 Gene:tyro3 / 30709 ZFINID:ZDB-GENE-990714-13 Length:868 Species:Danio rerio


Alignment Length:805 Identity:196/805 - (24%)
Similarity:312/805 - (38%) Gaps:273/805 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 VSSKPYWRNPKKMSFLQTRP------SGSLLTLNCHALGNPEP-NITWYRNG----------TVD 144
            :||:|.|.....:......|      :|....|.|.|.|.||| .:.|:..|          :|.
Zfish   104 ISSEPAWITVAGVPHFGVEPEDVAAFAGESFNLTCAASGPPEPVEVLWWLGGEQNGDFTPSPSVL 168

  Fly   145 WTRGYG-SLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNL 208
            :.:|.. |:|                  :.|:..|:.|                           
Zfish   169 FVKGVNESIK------------------FHCEAKNARG--------------------------- 188

  Fly   209 TLVVNSTGSMHCK------------YLSDLTSKKAWI--FVPCHGMTNCSNNRSIIAEDKDQLDF 259
             :.|:.||::|.|            ::||......|.  |.....::.|:...|.....|.:|..
Zfish   189 -ISVSRTGTVHIKARPDSPRDVQVHHVSDFNITLTWSPGFTGHSQLSTCTIQLSRGPGKKVKLPD 252

  Fly   260 VNVRMEQ-----EGWYT---------CVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSF 310
            |.|.:..     ||..:         |  .|.:|.|..:.::    ..|..:   |:.|....:|
Zfish   253 VVVEVPPFQHVFEGLRSYSNYSVRVRC--DNEVGSSPFSPWV----DFHTPQ---AAPSAAPKNF 308

  Fly   311 VYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQW-----TKKVIIFKPEGGGDSSG- 369
            .:......|...:.|          ::.|::..:.:....||     ::..::|| |.....|| 
Zfish   309 TFDLSEQQLTLSWAT----------LEQEELRGRLLAYKLQWNQGGESQDPLLFK-ENVAHLSGA 362

  Fly   370 ---------------------SMDTMIMPVVRIQKQR------------------------TTVL 389
                                 |...::|||..:|.|.                        ..:.
Zfish   363 GRFFNATFQVAACTMAGCGPWSQPVLVMPVSAMQAQTQRGHMWVGLLFGLLVATMVGLLLIVLIR 427

  Fly   390 QNGNE--------------PAPFN-----EYEFPLDSNWELPRSH-------------------- 415
            ..|.|              |..|.     ..:||     |||.|.                    
Zfish   428 NRGKETQFGSAFAAQGAEVPVSFTAARSFNRQFP-----ELPESTLDSLGINSDLKAKLQDVLIS 487

  Fly   416 ---LVLGATLGEGAFGRV---VMAEVNNA--IVAVKMVK-EGHTDDDIASLVREMEVMKIIGRHI 471
               |.||..||:|.||.|   .:...||:  .||||::| :.::..||...::|...||.. .|.
Zfish   488 ERLLTLGRMLGKGEFGSVREAFLKSENNSGQKVAVKVLKTDINSSSDIEQCLKEAAYMKDF-HHP 551

  Fly   472 NIINLLGC-----CSQNGPL-YVIVEYAPHGNLKDFLYKNR----PFGRDQDRDSSQPPPSPPAH 526
            |:|.|:|.     ..|..|: .||:.:..||:|..||..:|    ||                  
Zfish   552 NVIQLIGVSLHRRAQQRLPVPMVILPFMKHGDLHTFLLMSRLGDEPF------------------ 598

  Fly   527 VITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT 591
            .::::.||:|...|||||:||:::..|||||||||.:::::..:.:|||||::.|.|.||||:.:
Zfish   599 TVSQQILIQFMLDIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGLSKKIYSGDYYRQGS 663

  Fly   592 NGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKP 656
            ..:||:||:|.|||.:..|.::||||::|:.:|||||.||.|||.:.:: |:|.||:.|:|:::|
Zfish   664 VSKLPVKWIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVENS-EIYEYLIKGERLKQP 727

  Fly   657 AKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL------LQTKEDYLDVDI-------ANLDT 708
            ..|..:||.:|..||......||.|..:::.::.|      ...||..|.|::       ||..|
Zfish   728 PDCPADIYEIMHSCWSPVPKCRPSFQHLIDQLELLWAKLNPAPVKEPLLYVNLEEEDGEQANSGT 792

  Fly   709 PPSTSDE------------EEDETD 721
              .:|:|            ||||.|
Zfish   793 --RSSEEPSWGVPWQCAGIEEDEKD 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 20/107 (19%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 1/4 (25%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 21/116 (18%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 1/13 (8%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 114/332 (34%)
tyro3NP_571507.2 Ig 31..113 CDD:472250 4/8 (50%)
Ig strand B 38..42 CDD:409353
Ig strand C 51..55 CDD:409353
Ig strand E 78..82 CDD:409353
Ig strand F 92..97 CDD:409353
Ig strand G 106..109 CDD:409353 1/2 (50%)
IgI_2_Axl_Tyro3_like 118..198 CDD:409407 21/125 (17%)
Ig strand A 118..121 CDD:409407 0/2 (0%)
Ig strand A' 124..128 CDD:409407 0/3 (0%)
Ig strand B 132..141 CDD:409407 2/8 (25%)
Ig strand C 146..153 CDD:409407 2/6 (33%)
Ig strand C' 155..158 CDD:409407 1/2 (50%)
Ig strand E 163..173 CDD:409407 1/9 (11%)
Ig strand F 176..185 CDD:409407 3/26 (12%)
Ig strand G 189..198 CDD:409407 3/8 (38%)
FN3 203..296 CDD:238020 16/98 (16%)
FN3 304..387 CDD:238020 12/93 (13%)
Protein Kinases, catalytic domain 481..764 CDD:473864 109/302 (36%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.