DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and fgfr1a

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_694494.2 Gene:fgfr1a / 30705 ZFINID:ZDB-GENE-980526-255 Length:810 Species:Danio rerio


Alignment Length:696 Identity:275/696 - (39%)
Similarity:382/696 - (54%) Gaps:67/696 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 TNNANQSSTSSADLDDGAADDD--DNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHA 127
            |...|.|.|...|..|.::::.  .|..:||:    .|.|..|.|| ..|...|:...:...|.|
Zfish   109 TEYFNISVTDEEDEVDSSSEEAKLSNDQNLPM----APVWAQPDKMEKKLHAVPASKTVKFRCQA 169

  Fly   128 LGNPEPNITWYRNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQV 189
            .|||.|.:.|.:||..   |...|...::.:.||:.||.:||.|.|||||.|.|..|.|.|..|:
Zfish   170 NGNPTPTLKWLKNGKEFKRDQRIGGFKVREHMWTIIMESVVPSDRGNYTCLVENRHGSINHTYQL 234

  Fly   190 IVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWI-FVPCHG---------MTNC 243
            .|.:|..|:|||..| |.|.|.||.|.....||..||......|: .:..:|         ....
Zfish   235 DVVERSPHRPILQAGLPANRTAVVGSDVEFECKVFSDPQPHIQWLKHIEVNGSRYGPDGLPYVRA 299

  Fly   244 SNNRSIIAEDKDQ--LDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLH 306
            .....:...||:.  |...||.:|..|.|||:..||:|.|:.:|:|.|.::       |....|.
Zfish   300 LKTAGVNTTDKEMEVLQIRNVSLEDAGEYTCLAGNSIGHSHHSAWLTVYKA-------VPPTQLP 357

  Fly   307 STSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIET---VHQWTKKVIIFKP-EGGGDS 367
            :.:::.:.::  .:..|:..:.|..|:....|....|....:   ||:..|.:.:.:. ....||
Zfish   358 NQTYLEVLIY--CVGFFLICVMVGTAVLAKMHSSAKKSDFNSQLAVHKLAKSIPLRRQVTVSVDS 420

  Fly   368 SGSMDTMIMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRV 430
            |.||.:..|.|      |.:.|.:...|  :..:|||.|.|..||:.|..||||..||||.||:|
Zfish   421 SSSMHSGGMLV------RPSRLSSSGSPMLSGVSEYELPQDPRWEVQRDRLVLGKPLGEGCFGQV 479

  Fly   431 VMAEV-------NNAI--VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPL 486
            :|||.       .|.|  |||||:|...|:.|::.|:.|||:|||||:|.|||||||.|:|:|||
Zfish   480 MMAEAMGMDKEKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPL 544

  Fly   487 YVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRR 551
            |||||:|..|||:::|...||.|.:.    ...|...|...::.|||:..|:|:||||:||||::
Zfish   545 YVIVEFAAKGNLREYLRVRRPPGMEY----CYNPDQVPVENMSIKDLVSCAYQVARGMEYLASKK 605

  Fly   552 CIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDV 616
            |||||||||||||::|.|:|||||||||||...|||:|.||||||:||||||:|.::.|..:|||
Zfish   606 CIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDV 670

  Fly   617 WSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPF 681
            ||:|:|||||.|.|..|||.: ..|||:..|..|.||::|:.|:..:|::||.|||.....||.|
Zfish   671 WSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDRPSTCTHELYMMMRDCWHAVPSQRPTF 734

  Fly   682 TEIVEYMDKLLQ--TKEDYLDVDIA------NL-DTPPSTSDEEED 718
            .::||.:|:.|.  :.::|||:.::      |. ||..||....||
Zfish   735 KQLVEDLDRTLSMTSNQEYLDLSVSLDQFSPNFPDTRSSTCSSGED 780

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 36/93 (39%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 2/3 (67%)
Ig strand F 171..176 CDD:409353 4/4 (100%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 31/101 (31%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/5 (20%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 160/296 (54%)
fgfr1aNP_694494.2 Ig 28..116 CDD:472250 2/6 (33%)
Ig strand B 49..53 CDD:409353
Ig strand C 61..65 CDD:409353
Ig strand E 82..86 CDD:409353
Ig strand F 96..101 CDD:409353
Ig strand G 109..112 CDD:409353 1/2 (50%)
Ig 142..236 CDD:472250 36/93 (39%)
Ig strand B 163..167 CDD:409353 0/3 (0%)
Ig strand C 176..180 CDD:409353 0/3 (0%)
Ig strand E 202..206 CDD:409353 2/3 (67%)
Ig strand F 216..221 CDD:409353 4/4 (100%)
Ig strand G 229..232 CDD:409353 1/2 (50%)
Ig 244..347 CDD:472250 32/102 (31%)
Ig strand B 262..266 CDD:409353 0/3 (0%)
Ig strand C 275..279 CDD:409353 0/3 (0%)
Ig strand E 313..317 CDD:409353 1/3 (33%)
Ig strand F 327..332 CDD:409353 3/4 (75%)
Ig strand G 340..343 CDD:409353 0/2 (0%)
PTKc_FGFR1 451..752 CDD:270678 162/305 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 787..810
Blue background indicates that the domain is not in the aligned region.

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