DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and fgfr1a

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_009302578.1	Gene:	fgfr1a / 30705	ZFINID:	ZDB-GENE-980526-255	Length:	811	Species:	Danio rerio

Alignment Length:	694	Identity:	278/694 - (40%)
Similarity:	382/694 - (55%)	Gaps:	62/694 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TNNANQSSTSSADLDDGAADDD--DNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHA 127
            |...|.|.|...|..|.::::.  .|..:||:    .|.|..|.|| ..|...|:...:...|.|
Zfish   109 TEYFNISVTDEEDEVDSSSEEAKLSNDQNLPM----APVWAQPDKMEKKLHAVPASKTVKFRCQA 169

  Fly   128 LGNPEPNITWYRNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQV 189
            .|||.|.:.|.:||..   |...|...::.:.||:.||.:||.|.|||||.|.|..|.|.|..|:
Zfish   170 NGNPTPTLKWLKNGKEFKRDQRIGGFKVREHMWTIIMESVVPSDRGNYTCLVENRHGSINHTYQL 234

  Fly   190 IVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWI-FVPCHG---------MTNC 243
            .|.:|..|:|||..| |.|.|.||.|.....||..||......|: .:..:|         ....
Zfish   235 DVVERSPHRPILQAGLPANRTAVVGSDVEFECKVFSDPQPHIQWLKHIEVNGSRYGPDGLPYVRA 299

  Fly   244 SNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHST 308
            ..|..:.:.|...|...||..||.|.|.|..||.:||:|.:|:|.||:.|.    .|....|.:.
Zfish   300 LKNSGVNSSDTQVLTLYNVTEEQSGEYICKVSNYIGQANQSAWLTVVKHLQ----AVPPTQLPNQ 360

  Fly   309 SFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIET---VHQWTKKVIIFKP-EGGGDSSG 369
            :::.:.::  .:..|:..:.|..|:....|....|....:   ||:..|.:.:.:. ....|||.
Zfish   361 TYLEVLIY--CVGFFLICVMVGTAVLAKMHSSAKKSDFNSQLAVHKLAKSIPLRRQVTVSVDSSS 423

  Fly   370 SMDTMIMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVM 432
            ||.:..|.|      |.:.|.:...|  :..:|||.|.|..||:.|..||||..||||.||:|:|
Zfish   424 SMHSGGMLV------RPSRLSSSGSPMLSGVSEYELPQDPRWEVQRDRLVLGKPLGEGCFGQVMM 482

  Fly   433 AEV-------NNAI--VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYV 488
            ||.       .|.|  |||||:|...|:.|::.|:.|||:|||||:|.|||||||.|:|:|||||
Zfish   483 AEAMGMDKEKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLYV 547

  Fly   489 IVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCI 553
            |||:|..|||:::|...||.|.:.    ...|...|...::.|||:..|:|:||||:||||::||
Zfish   548 IVEFAAKGNLREYLRVRRPPGMEY----CYNPDQVPVENMSIKDLVSCAYQVARGMEYLASKKCI 608

  Fly   554 HRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWS 618
            |||||||||||::|.|:|||||||||||...|||:|.||||||:||||||:|.::.|..:|||||
Zfish   609 HRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWS 673

  Fly   619 YGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTE 683
            :|:|||||.|.|..|||.: ..|||:..|..|.||::|:.|:..:|::||.|||.....||.|.:
Zfish   674 FGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQ 737

  Fly   684 IVEYMDKLLQ--TKEDYLDVDIA------NL-DTPPSTSDEEED 718
            :||.:|:.|.  :.::|||:.::      |. ||..||....||
Zfish   738 LVEDLDRTLSMTSNQEYLDLSVSLDQFSPNFPDTRSSTCSSGED 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	31/81 (38%)
		IG_like	113..191	CDD:214653	30/80 (38%)
		IG_like	205..289	CDD:214653	29/93 (31%)
		PKc_like	404..692	CDD:304357	160/296 (54%)
		STYKc	416..688	CDD:214568	154/280 (55%)
fgfr1a	XP_009302578.1	Ig	28..116	CDD:416386	2/6 (33%)
		Ig strand A	28..31	CDD:409353
		Ig strand A'	38..44	CDD:409353
		Ig strand B	47..57	CDD:409353
		Ig strand C	61..66	CDD:409353
		Ig strand C'	69..71	CDD:409353
		Ig strand D	76..80	CDD:409353
		Ig strand E	83..88	CDD:409353
		Ig strand F	94..103	CDD:409353
		Ig strand G	106..116	CDD:409353	2/6 (33%)
		Ig	142..236	CDD:416386	36/93 (39%)
		Ig strand A	142..145	CDD:409353	1/2 (50%)
		Ig strand A'	153..158	CDD:409353	1/4 (25%)
		Ig strand B	162..170	CDD:409353	1/7 (14%)
		Ig strand C	176..181	CDD:409353	1/4 (25%)
		Ig strand C'	184..186	CDD:409353	0/1 (0%)
		Ig strand D	195..198	CDD:409353	0/2 (0%)
		Ig strand E	202..207	CDD:409353	2/4 (50%)
		Ig strand F	216..223	CDD:409353	5/6 (83%)
		Ig strand G	226..236	CDD:409353	4/9 (44%)
		Ig	244..345	CDD:416386	33/100 (33%)
		Ig strand A	244..247	CDD:409353	2/2 (100%)
		Ig strand A'	251..255	CDD:409353	2/3 (67%)
		Ig strand B	263..270	CDD:409353	2/6 (33%)
		Ig strand C	274..281	CDD:409353	1/6 (17%)
		Ig strand D	296..301	CDD:409353	0/4 (0%)
		Ig strand E	311..316	CDD:409353	1/4 (25%)
		Ig strand F	324..332	CDD:409353	3/7 (43%)
		Ig strand G	335..343	CDD:409353	4/7 (57%)
		FGFR3_TM	358..387	CDD:407957	3/30 (10%)
		PTKc_FGFR1	452..753	CDD:270678	162/305 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1538
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm6455
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.910