Protein Alignment htl and ephb4b

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_571492.1
• Gene: ephb4b / 30691
• ZFINID: ZDB-GENE-990415-65
• Length: 976
• Species: Danio rerio
• Alignment Length: 669
• Identity: 157/669 - (23%)
• Similarity: 271/669 - (40%)
• Gaps: 173/669 - (25%)

  Fly    91 ADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRN 155
            :|||.:..:||           .:.|...:..:|...:             |::|:.......|:
Zfish   316 SDLPDSACTKP-----------PSAPRSIIYQINDTVV-------------TLEWSEPLDRGGRS 356

  Fly   156 RWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKP---------ILMTGPLNLT-- 209
            ..:.::|           |..|....|::      .:|.:.::|         :::.|.|..|
Zfish   357 DLSYSVE-----------CMHCRGSLCVQ------CADSITYRPGQMGVSGRRVIIRGLLPHTTY 404

  Fly   210 ----LVVNSTGSM-HCKYLS---DLTSKKAWIFVPCHGMTNCSNNRSIIA-------------ED 253
                |..|...:: |....|   ::|:.:. :.||..|:.....:.|.::             :|
Zfish   405 TFTVLAQNGVSAVSHTSPASSSVNITTSRD-VAVPVSGIRRIKASESSVSISWTVPPQTQHSIQD 468

  Fly   254 KDQLDFVNVRMEQEGW-YTCVESNSL---GQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYI- 313
            . ||.: :::.:.:|| |....|:|:   ..|.::.|...||      |..|:|..|.:|.|.|
Zfish   469 Y-QLRY-SLKGQDDGWQYVSSRSSSVVLNDLSRASQYQVQVR------ARTAAGYGHFSSAVSIS 525

  Fly   314 -----------------FVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKP 361
                             .|..||:.:....:...:..|:....:
Zfish   526 TLPDDEESPSRLMLTGVLVAIGLLILIAVVIVAVFCFRRSTRRR--------------------- 569

  Fly   362 EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPR----SHLVLGATL 422
            :...|.||..         :..|...|..:     ||. ||.|.::..|..:    |.:.:...:
Zfish   570 DPDPDKSGQF---------LMGQGIKVYID-----PFT-YEDPNEAVREFAKEIDVSFVKIEEVI 619

  Fly   423 GEGAFGRVVMAEV-----NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ 482
            |.|.||.|....:     ....||:|.:|.|:||......:.|..:|... :|.|||:|.|..:.
Zfish   620 GAGEFGEVCRGRLKVPGKKENYVAIKTLKGGYTDKQRRDFLSEASIMGQF-QHPNIIHLEGVITA 683

  Fly   483 NGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYL 547
            :.|:.::.||..:|.|..||..|         |..          .|...|:.....||.||.||
Zfish   684 SCPVMILTEYMENGALDSFLRLN---------DGQ----------FTPIQLVGMLRGIASGMKYL 729

  Fly   548 ASRRCIHRDLAARNVLVSDDYVLKIADFGLAR---DIQSTDYYRKNTNGRLPIKWMAPESLQEKF 609
            :....:||||||||:||:.:.|.|::||||:|   :..|...|..:..|::||:|.|||::..:.
Zfish   730 SEMSFVHRDLAARNILVNSNLVCKVSDFGLSRFLTENSSDPTYTSSLGGKIPIRWTAPEAIAFRK 794

  Fly   610 YDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFN 674
            :.|.||||||||::||:|::|::|| ..||.:::...:....|:..|.:|..:::.||..||...
Zfish   795 FTSASDVWSYGIVMWEVMSFGERPY-WDMSNQDVINAIEQDYRLPPPPECPASLHQLMLDCWQKE 858

  Fly   675 ADDRPPFTEIVEYMDKLLQ 693
            ...||.|..||..:|:|::
Zfish   859 RSSRPRFCAIVSALDRLIR 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	10/89 (11%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	22/115 (19%)
		Ig strand B	216..220	CDD:409353	0/4 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	2/3 (67%)
		Ig strand F	269..274	CDD:409353	2/5 (40%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	96/299 (32%)
ephb4b	NP_571492.1	EphR_LBD	25..198	CDD:470656
		FN3	327..431	CDD:238020	18/133 (14%)
		FN3	438..526	CDD:238020	22/95 (23%)
		EphA2_TM	540..610	CDD:464211	15/105 (14%)
		PTKc_EphR_B	608..876	CDD:173638	94/288 (33%)
		SAM_superfamily	906..969	CDD:472832