DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and HCK

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_002101.2 Gene:HCK / 3055 HGNCID:4840 Length:526 Species:Homo sapiens


Alignment Length:561 Identity:167/561 - (29%)
Similarity:250/561 - (44%) Gaps:84/561 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 CNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCK-YLSDLTS--KKAWIFVPCH 238
            |...||.|.:.:......:..|.:.:.|  |......::.|.||. |:.|.||  |..    |..
Human     7 CEDPGCPRDEERAPRMGCMKSKFLQVGG--NTFSKTETSASPHCPVYVPDPTSTIKPG----PNS 65

  Fly   239 GMTNCSNNRSIIAED-------------KDQLDFVN----VRMEQEG-WYTCVESNSLGQSNS-- 283
            ..:|....|...:||             .:.|.|..    |.:|:.| |:   ::.||.....  
Human    66 HNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWW---KARSLATRKEGY 127

  Fly   284 --TAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFM----TTLFVFYAIRKMKHEKVL 342
              :.|:..|.||.. |.....|.....:...:...|.::..||    .|....|::....::   
Human   128 IPSNYVARVDSLET-EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYD--- 188

  Fly   343 KQRIETVHQWTKKVIIFKPEGGG---DSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFP 404
            .::.:||..:..:.:    :.||   ....:..|:...|...:|....:.|..:.|...::.:.|
Human   189 PRQGDTVKHYKIRTL----DNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKP 249

  Fly   405 LDSN-WELPRSHLVLGATLGEGAFGRVVMAEVN-NAIVAVKMVKEGHTDDDIASLVREMEVMKII 467
            .:.: ||:||..|.|...||.|.||.|.||..| :..||||.:|.|..  .:.:.:.|..|||.:
Human   250 WEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSM--SVEAFLAEANVMKTL 312

  Fly   468 GRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKD 532
             :|..::.|....::. |:|:|.|:...|:|.|||        ..|..|.||.|.          
Human   313 -QHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFL--------KSDEGSKQPLPK---------- 357

  Fly   533 LIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPI 597
            ||.|:.|||.||.::..|..|||||.|.|:|||...|.|||||||||.|:..:|..:. ..:.||
Human   358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTARE-GAKFPI 421

  Fly   598 KWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMN 662
            ||.|||::....:..||||||:||||.||:|||:.|||. ||..|:...|..|.||.:|..|...
Human   422 KWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG-MSNPEVIRALERGYRMPRPENCPEE 485

  Fly   663 IYILMRQCWHFNADDRPPFTEIVEYMDKLLQ-----TKEDY 698
            :|.:|.:||....::||.|    ||:..:|.     |:..|
Human   486 LYNIMMRCWKNRPEERPTF----EYIQSVLDDFYTATESQY 522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 4/13 (31%)
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 24/113 (21%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 1/3 (33%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/6 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 116/289 (40%)
HCKNP_002101.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 4/12 (33%)
SH3 82..137 CDD:473055 9/57 (16%)
SH2_Src_HCK 140..243 CDD:198226 16/110 (15%)
Protein Kinases, catalytic domain 254..524 CDD:473864 118/297 (40%)
Blue background indicates that the domain is not in the aligned region.

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