DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and ret

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_858048.2	Gene:	ret / 30512	ZFINID:	ZDB-GENE-980526-307	Length:	1106	Species:	Danio rerio

Alignment Length:	710	Identity:	210/710 - (29%)
Similarity:	310/710 - (43%)	Gaps:	178/710 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSF 111
            ||:....:....|||..|.|    |.:.|.    .|.|  |..|.|            .|:..:.
Zfish   472 QELEYVVIAQEQQNKLQAKT----QLTVSF----QGEA--DSLKTD------------EPRFPAC 514

  Fly   112 LQTRPSGSLLTLNCHA---LGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYT 173
            .:.|..|     :|.|   ||.|        .|...|.:|.......|::....:|  |.|.:..
Zfish   515 AEKRQRG-----DCEATRGLGAP--------TGRCQWRQGRDKGISKRYSTCSPNL--GTCPDGY 564

  Fly   174 CKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVN--STGSMHCKYLSDLTSKKAWIFVP 236
            |                  |.:..|        |:::...  |:.::...|..||...||.
Zfish   565 C------------------DAIESK--------NISICPQDCSSEAIIGGYERDLYGIKAG---- 599

  Fly   237 CHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVA 301
             ||...|...:.....|:.:.|..|                                .:.:..:|
Zfish   600 -HGTCYCFEGKCFCERDEPEDDICN--------------------------------DMCKTVIA 631

  Fly   302 SGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGD 366
            :|.:  .||:        :.:.:::.|                 |...|:.|.|    .|....:
Zfish   632 TGII--LSFI--------VSVLLSSYF-----------------IHRYHKTTPK----PPIASAE 665

  Fly   367 SSGSMDTMIMPV-VRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRV 430
            .:........|: ......|...|.:.......:.::.|.|..||.||.:||||.|||||.||:|
Zfish   666 MTFRRPAQSYPISYSANNVRRASLDSMENQVAIDTFKIPEDPKWEFPRKNLVLGKTLGEGEFGKV 730

  Fly   431 VMA-------EVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYV 488
            |.|       :.....|||||:||..:..::..|:.|..::|.: .|.::|.:.|.|||:||||:
Zfish   731 VKATAFRLKGKAGYTTVAVKMLKENASHSELRDLLSEFTLLKQV-NHPHVIKMYGACSQDGPLYL 794

  Fly   489 IVEYAPHGNLKDFLYKNRP-----FGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLA 548
            |||||.:|:|::||.::|.     .|.|.:|:||. ..:|....:|..|||.||.||:|||.|||
Zfish   795 IVEYAKYGSLRNFLRESRKVGPSYMGNDANRNSSY-LENPDERALTMGDLISFAWQISRGMQYLA 858

  Fly   549 SRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSK 613
            ..:.:|||||||||||::...:||:||||:||:...|.|.|.:.||:|:||||.|||.:..|.::
Zfish   859 EMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQ 923

  Fly   614 SDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDR 678
            |||||:|:|||||:|.|..|||.| :.|.|:..|.:|.|||||..|:..:|.||.:||...:|.|
Zfish   924 SDVWSFGVLLWEIVTLGGNPYPGI-APERLFNLLKTGYRMEKPENCTDEMYNLMLRCWKQESDKR 987

  Fly   679 PPFTEIVEYMDKLLQTKEDYLD-----------------------VDIANLDTP---PST 712
            |.|::|.:.::|::....||||                       ||.:|...|   |||
Zfish   988 PTFSDISKELEKMMVKSRDYLDLAASTPADALLYDDSLSEEDTPLVDCSNAPLPRTLPST 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	15/81 (19%)
		IG_like	113..191	CDD:214653	15/80 (19%)
		IG_like	205..289	CDD:214653	13/85 (15%)
		PKc_like	404..692	CDD:304357	141/299 (47%)
		STYKc	416..688	CDD:214568	134/283 (47%)
ret	NP_858048.2	CA	186..256	CDD:214520
		PTKc_RET	715..1004	CDD:173631	135/291 (46%)
		Pkinase_Tyr	716..997	CDD:285015	134/283 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810