DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and kita

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_009292910.1	Gene:	kita / 30256	ZFINID:	ZDB-GENE-980526-464	Length:	981	Species:	Danio rerio

Alignment Length:	765	Identity:	221/765 - (28%)
Similarity:	327/765 - (42%)	Gaps:	183/765 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 ITNNANQSSTSSADLDDGAADDDDNKADLPVN---VSSKPYWRNPKKMSFL-------QTR--PS 117
            :|.......|:...|......|..|.:...:|   .::||.|.|..:..|:       .||  .:
Zfish   263 LTEPITHVRTAILSLSSVTMQDAGNYSCEAINEKGTTAKPVWVNIYEKGFINITSVDNSTRRVRA 327

  Fly   118 GSLLTLNCHALGNPEPN-ITWYRNG-----TVD---WTRGYGSLKRNRWT--LTMEDLVPGDCGN 171
            |..|:|.......|:|: .:|..:|     |.|   .:|.:|    |.:|  |.:..|...:.|.
Zfish   328 GESLSLRVVMNAYPKPHTFSWSYSGVKLTNTTDHVITSRTHG----NSYTSELKLVRLKVSESGI 388

  Fly   172 YTCKVCNSLGCIRHDTQVIVSDRVNHKPILMT--GPLNLTLVVNSTGSMHCKYLSDLTSKKAWIF 234
            ||....|....||...:|    .|..||.:::  ||::        |.:.|......|.:..|.:
Zfish   389 YTFSCLNRDATIRQTFEV----HVISKPQIVSYEGPID--------GQVRCVAEGYPTPQIKWYY 441

  Fly   235 VPC---HGMTNCSNNRSIIAEDKDQLDFVNVRMEQ----EGWYTCVESNSLGQSNSTAYLRVVRS 292
              |   |  :.|||   ::...:::.|.|.|.|..    :|   .|||......|:.|.|..|.|
Zfish   442 --CDLPH--SRCSN---LLNATQEEEDVVTVTMTNPPFGKG---AVESRLNITKNNYATLECVAS 496

  Fly   293 LHVLEAGVASGSLHSTSF---------------VYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVL 342
                    |:|.:..|.|               :..||...:|.:.:..:..:..::|.|::
Zfish   497 --------ANGEIVYTLFSISENTVPHELFTPLLIGFVAAAVILVLILIVLTYKYMQKPKYQ--- 550

  Fly   343 KQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDS 407
                   .||  |||    ||                          .:||.....:..:.|.|.
Zfish   551 -------IQW--KVI----EG--------------------------IHGNNYVYIDPTQLPYDH 576

  Fly   408 NWELPRSHLVLGATLGEGAFGRVV------MAEVNNAI-VAVKMVKEGHTDDDIASLVREMEVMK 465
            .||.||..|..|.|||.||||:||      |::.:..: |||||:|......:..:|:.|::|:.
Zfish   577 QWEFPRDKLRFGKTLGSGAFGKVVEATAYGMSKADTVMTVAVKMLKPSAHATEKEALMSELKVLS 641

  Fly   466 IIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPF------GRD----------QDR 514
            .:|.||||:||||.|:..||..||.||...|:|.:||.:.|.:      |.|          :..
Zfish   642 YLGNHINIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRRRVYFYYTTLGEDAYYRNVMMQSEPN 706

  Fly   515 DS---------------------------SQPPPSPPAHVITE-------KDLIKFAHQIARGMD 545
            ||                           |.......:.::.|       :||:.|::|:|:|||
Zfish   707 DSRNGYMTMKPSVLGILSSENRRSLNKGDSYSDSDAVSEILQEDGLTLDTEDLLSFSYQVAKGMD 771

  Fly   546 YLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFY 610
            :|||:.||||||||||:|::...|.||.||||||||.:...|....|.|||:|||:|||:.|..|
Zfish   772 FLASKNCIHRDLAARNILLTQGRVAKICDFGLARDITTDSNYVVKGNARLPVKWMSPESIFECVY 836

  Fly   611 DSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNA 675
            ..:|||||||||||||.:.|..|||.:....:.|..:..|.|||.|......:|.:|..||..:.
Zfish   837 TFESDVWSYGILLWEIFSLGSSPYPGMPVDSKFYKMIKEGYRMESPEFSPSEMYDIMHSCWDADP 901

  Fly   676 DDRPPFTEIVEYMDKLL--QTKEDYLDVDIANLDTPPSTSDEEEDETDNL 723
            ..||.|::|||.:::.:  .||..||:.. :.|...|...:|.......|
Zfish   902 VKRPSFSKIVEKIEQQISDSTKHIYLNFS-SRLPAAPGPREESSSHVHRL 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	24/98 (24%)
		IG_like	113..191	CDD:214653	24/90 (27%)
		IG_like	205..289	CDD:214653	21/90 (23%)
		PKc_like	404..692	CDD:304357	133/344 (39%)
		STYKc	416..688	CDD:214568	127/328 (39%)
kita	XP_009292910.1	IG_like	123..203	CDD:214653
		IG_like	218..307	CDD:214653	9/43 (21%)
		ig	218..297	CDD:278476	6/33 (18%)
		Ig	311..410	CDD:299845	26/106 (25%)
		IG_like	325..408	CDD:214653	22/90 (24%)
		PTKc_Kit	549..918	CDD:270682	142/410 (35%)
		Pkinase_Tyr	585..914	CDD:285015	127/328 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810