Protein Alignment htl and Ntrk3

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001257585.1
• Gene: Ntrk3 / 29613
• RGDID: 3214
• Length: 864
• Species: Rattus norvegicus
• Alignment Length: 922
• Identity: 216/922 - (23%)
• Similarity: 331/922 - (35%)
• Gaps: 318/922 - (34%)

  Fly    24 LFLLLSIWQ---------PA------VQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSS 73
            :|||.|:|.         ||      .::..||              ....|..|.:....:.:|
  Rat    15 IFLLGSVWLDYVGSVLACPANCVCSKTEINCRR--------------PDDGNLFPLLEGQDSGNS 65

  Fly    74 TSSADLDDGAADDDDNKADLPVNVSS--KPYWRNPKKMSFLQTRPSGSL--LTLNCHALGNPEPN 134
            ..:|.:         |..|:..|::|  ...||....::.:.......|  ||:....|.|.:|.
  Rat    66 NGNASI---------NITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPR 121

  Fly   135 ITWYRNGTVDWTRGYGSLKRNR-----W----TLTMEDL-VPGDCGNYTCKV------------- 176
             .:.:|..:    .|.:|..||     |    ||::.:| :..:..|.:|.:
  Rat   122 -AFAKNPHL----RYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEAR 181

  Fly   177 --CNSLGCIRHDTQVIVSDRVN----HKPILMTGPLNLT--------LVVNSTGSMHCKYLSDLT 227
              ..||.||..|...:...|:|    ..|.:....:|||        :..|.:||.    |.|:.
  Rat   182 LDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSP----LPDVD 242

  Fly   228 SKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGW-YTCVESNSLGQSNSTAYLRV-- 289
                ||......:.....|.:........|..|||..|..|: .||:..|.:|.||::..|.|
  Rat   243 ----WIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYY 303

  Fly   290 -----------VRSLHVLE---AGVASGSLH---------STSFVYIFVF-------GGLIFIFM 324
                       ||..|.:|   .|..:.:||         .:..:::..:       |.|:|
  Rat   304 PPRVVSLVEPEVRLEHCIEFVVRGNPTPTLHWLYNGQPLRESKIIHMDYYQEGEVSEGCLLF--- 365

  Fly   325 TTLFVFYAIRKMKHEK------VLKQRIETVHQ-----WTKK---------------------VI 357
                     .|..|..      :.|..:.|.:|     :.|:                     .:
  Rat   366 ---------NKPTHYNNGNYTLIAKNALGTANQTINGHFLKEPFPESTDFFDFESDASPTPPITV 421

  Fly   358 IFKPE----------------------------------------------GGGDSSGSM----- 371
            ..|||                                              |..||:..:
  Rat   422 THKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINH 486

  Fly   372 ------------DTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELP--------RSHL 416
                        ||:::.:.||             |...|...|....|...|        |..:
  Rat   487 GITTPSSLDAGPDTVVIGMTRI-------------PVIENPQYFRQGHNCHKPDTYVQHIKRRDI 538

  Fly   417 VLGATLGEGAFGRVVMAEVNN-------AIVAVKMVKEGHTDDDIAS---LVREMEVMKIIGRHI 471
            ||...|||||||:|.:||..|       .:||||.:|    |..:|:   ..||.|::..: :|.
  Rat   539 VLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK----DPTLAARKDFQREAELLTNL-QHE 598

  Fly   472 NIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKF 536
            :|:...|.|....||.::.||..||:|..||..:.|       |:.......|.....|..|.:.
  Rat   599 HIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGP-------DAMILVDGQPRQAKGELGLSQM 656

  Fly   537 AH---QIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRK--------- 589
            .|   |||.||.||||:..:|||||.||.||..:.::||.|||::||:.||||||:
  Rat   657 LHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPYQKGPFS 721

  Fly   590 -----------------NTNGR-------------LPIKWMAPESLQEKFYDSKSDVWSYGILLW 624
                             |.:|.             |||:||.|||:..:.:.::|||||:|::||
  Rat   722 VSWQQQRLAASAASTLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILW 786

  Fly   625 EIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMD 689
            ||.|||:||: ..:|..|:...:..|:.:|:|..|...:|.:|..||......|....||.:.:.
  Rat   787 EIFTYGKQPW-FQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILH 850

  Fly   690 KLLQTKEDYLDV 701
            .|.:....|||:
  Rat   851 ALGKATPIYLDI 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	24/116 (21%)
		Ig strand B	121..125	CDD:409353	2/3 (67%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	3/7 (43%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	24/97 (25%)
		Ig strand B	216..220	CDD:409353	2/3 (67%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	2/5 (40%)
		Ig strand G	282..285	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	114/347 (33%)
Ntrk3	NP_001257585.1	ig	214..299	CDD:395002	23/92 (25%)
		Ig strand B	227..231	CDD:409353	0/3 (0%)
		Ig strand C	240..244	CDD:409353	1/7 (14%)
		Ig strand E	266..270	CDD:409353	1/3 (33%)
		Ig strand F	281..286	CDD:409353	2/4 (50%)
		Ig strand G	294..297	CDD:409353	1/2 (50%)
		IgI_TrKABC_d5	304..396	CDD:409360	15/103 (15%)
		Ig strand A	305..311	CDD:409360	0/5 (0%)
		Ig strand A'	313..316	CDD:409360	0/2 (0%)
		Ig strand B	319..327	CDD:409360	2/7 (29%)
		Ig strand C	330..337	CDD:409360	2/6 (33%)
		Ig strand C'	340..343	CDD:409360	0/2 (0%)
		Ig strand D	348..354	CDD:409360	0/5 (0%)
		Ig strand E	358..366	CDD:409360	3/19 (16%)
		Ig strand F	374..382	CDD:409360	0/7 (0%)
		Ig strand G	385..393	CDD:409360	2/7 (29%)
		PTKc_TrkC	532..857	CDD:270676	113/337 (34%)
		LRRNT	31..>51	CDD:396168	4/33 (12%)
		LRR_8	103..160	CDD:404697	15/61 (25%)
		LRR 1	104..125		6/21 (29%)
		leucine-rich repeat	105..128	CDD:275378	7/23 (30%)
		LRR 2	128..149		5/24 (21%)
		leucine-rich repeat	129..151	CDD:275378	6/25 (24%)
		leucine-rich repeat	152..164	CDD:275378	1/11 (9%)
		LRRCT_2	163..208	CDD:465313	9/44 (20%)