DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Epha3

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_113752.2 Gene:Epha3 / 29210 RGDID:68389 Length:984 Species:Rattus norvegicus


Alignment Length:734 Identity:178/734 - (24%)
Similarity:282/734 - (38%) Gaps:226/734 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 TRPSGSLLTLNCHALGN-----PEP-------------NITWYRNGT---VDWTRGYGSLKRNRW 157
            |:..||   :||....|     .:|             |:....|.|   :||:          |
  Rat   296 TQEDGS---MNCRCENNYFRAEKDPPSMACTRPPSAPRNVISNINETSVILDWS----------W 347

  Fly   158 TLTMEDLVPGDCG-------NYTCKVC--NSLGC------IRH--------DTQVIVSDRVNHKP 199
                    |.|.|       |..||.|  |...|      :|.        :|.|.|:|.:.|  
  Rat   348 --------PLDTGGRKDITFNIICKKCGWNVRQCEPCSPNVRFLPRQLGLTNTTVTVTDLLAH-- 402

  Fly   200 ILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQ-------- 256
                  .|.|..:::...     :|:|:|.... |......||.:....::...||:        
  Rat   403 ------TNYTFEIDAING-----VSELSSPPRQ-FAAVSITTNQAAPSPVMTIKKDRTSRNSISL 455

  Fly   257 ------------LDF---VNVRMEQEGWYTCVESNSLGQSNS-----TAYLRVVRSLHVLEAGVA 301
                        ||:   ...:.|||..||.:.:.....:.|     |.|:..:|:......|..
  Rat   456 SWQEPEHPNGIILDYEVKYYEKQEQETSYTILRARGTNVTISSLKPDTTYVFQIRARTAAGYGTN 520

  Fly   302 SGSLH------------STSFVYIFVFGGLIFIFMTTLFVFYAI------RKMKHEKVLKQRIET 348
            |....            ..|.|.:......:.|.:.|:..:..:      .|.||..        
  Rat   521 SRKFEFETSPDSFSISGENSHVVMIAISAAVAIIVLTVVTYVLVGRFCGYHKSKHSS-------- 577

  Fly   349 VHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDS----NW 409
                .:|.:.|   |.|.            :|:...||.|     :|   :.||.|..:    ..
  Rat   578 ----DEKRLHF---GNGH------------LRLPGLRTYV-----DP---HTYEDPTQAVHEFAK 615

  Fly   410 ELPRSHLVLGATLGEGAF-----GRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR 469
            ||..:::.:...:|.|.|     ||:.:.......||:|.:|.|:|:......:.|..:|   |:
  Rat   616 ELDATNIAIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRRDFLGEASIM---GQ 677

  Fly   470 --HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKD 532
              |.|||.|.|..:::.|:.::.||..:|:|..||.|:         |:.          .|...
  Rat   678 FDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKH---------DAQ----------FTVIQ 723

  Fly   533 LIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNT-NGRLP 596
            |:.....||.||.||:....:||||||||:|::.:.|.|::||||:|.::........| .|::|
  Rat   724 LVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIP 788

  Fly   597 IKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSM 661
            |:|.:||::..:.:.|.||||||||:|||:|:||::|| ..||.:::...:..|.|:..|..|..
  Rat   789 IRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPY-WEMSNQDVIKAVDEGYRLPPPMDCPA 852

  Fly   662 NIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKE-----------------DYLDVDIANLDTP 709
            .:|.||..||..:.::||.|.:||..:|||::...                 |..:||||...| 
  Rat   853 ALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLKIITSAAARPSNLLLDQSNVDIATFHT- 916

  Fly   710 PSTSDEEEDETDNLQKWCN 728
              |.|           |.|
  Rat   917 --TGD-----------WLN 922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 25/120 (21%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 1/10 (10%)
Ig 200..289 CDD:472250 20/116 (17%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 2/23 (9%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 1/7 (14%)
Protein Kinases, catalytic domain 404..692 CDD:473864 98/299 (33%)
Epha3NP_113752.2 EphR_LBD_A3 29..201 CDD:198449
FN3 <323..>516 CDD:442628 42/224 (19%)
FN3 437..528 CDD:238020 15/90 (17%)
EphA2_TM <566..619 CDD:464211 17/87 (20%)
PTKc_EphR_A 617..883 CDD:270651 96/288 (33%)
SAM_EPH-A3 913..975 CDD:188943 5/24 (21%)
PDZ-binding. /evidence=ECO:0000255 982..984
Blue background indicates that the domain is not in the aligned region.

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