Protein Alignment htl and EPHA10

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001092909.1
• Gene: EPHA10 / 284656
• HGNCID: 19987
• Length: 1008
• Species: Homo sapiens
• Alignment Length: 669
• Identity: 150/669 - (22%)
• Similarity: 251/669 - (37%)
• Gaps: 199/669 - (29%)

  Fly    53 HL--GARSQNKTPA---ITNNANQSSTSSADL----DDGAA-DDDDNKADL--PVNVSSKPYWRN 105
            ||  |||...:..|   ::..|..:.|:.|.:    ..||. ::|:.:.|.  |.:||..  ||.
Human   414 HLRPGARYTVRVAALNGVSGPAAAAGTTYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLS--WRE 476

  Fly   106 PKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCG 170
            |        .|:|:      ....:.|..|.:|..|..:.|  |..:|....|:|:.:|.|.
Human   477 P--------IPAGA------PGANDTEYEIRYYEKGQSEQT--YSMVKTGAPTVTVTNLKPA--- 522

  Fly   171 NYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFV 235
                            |:.:...|.     ...||                         :|
Human   523 ----------------TRYVFQIRA-----ASPGP-------------------------SW--- 538

  Fly   236 PCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGV 300
                                         |.:.:...:|..:||::
Human   539 -----------------------------EAQSFNPSIEVQTLGEA------------------- 555

  Fly   301 ASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG 365
            ||||...:..:.:.|      :.::.|.|..::            :..:..|.:.....|  |||
Human   556 ASGSRDQSPAIVVTV------VTISALLVLGSV------------MSVLAIWRRPCSYGK--GGG 600

  Fly   366 DSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNE-----YEFPLDSNWELPRSHLVLGATLGEG 425
            |:....:....  .::..:||.:     :|....:     :.|..    ||....:.|..:||.|
Human   601 DAHDEEELYFH--FKVPTRRTFL-----DPQSCGDLLQAVHLFAK----ELDAKSVTLERSLGGG 654

  Fly   426 AFGRVV-----MAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR--HINIINLLGCCSQN 483
            .||.:.     :......:|||.|:::..:|......:.|   ...:|:  |.:|:.|.|..::.
Human   655 RFGELCCGCLQLPGRQELLVAVHMLRDSASDSQRLGFLAE---ALTLGQFDHSHIVRLEGVVTRG 716

  Fly   484 GPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLA 548
            ..|.::.||..||.|..||.::.  |:                 :....|:.....:|..|.||:
Human   717 STLMIVTEYMSHGALDGFLRRHE--GQ-----------------LVAGQLMGLLPGLASAMKYLS 762

  Fly   549 SRRCIHRDLAARNVLVSDDYVLKIADFGLA-RDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDS 612
            ....:||.||||:||||.|.|.||:.||.. ||.....|  ...:||.|..|.|||:||...:.|
Human   763 EMGYVHRGLAARHVLVSSDLVCKISGFGRGPRDRSEAVY--TTMSGRSPALWAAPETLQFGHFSS 825

  Fly   613 KSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADD 677
            .|||||:||::||:|.:|::|| ..||.:::...:..|.|:..|..|...::.||..||..:..:
Human   826 ASDVWSFGIIMWEVMAFGERPY-WDMSGQDVIKAVEDGFRLPPPRNCPNLLHRLMLDCWQKDPGE 889

  Fly   678 RPPFTEIVEYMDKLLQTKE 696
            ||.|::|...:.|::|..|
Human   890 RPRFSQIHSILSKMVQDPE 908

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	17/89 (19%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	1/3 (33%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	7/88 (8%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	0/4 (0%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	90/295 (31%)
EPHA10	NP_001092909.1	EphR_LBD_A10	35..210	CDD:198455
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..342
		fn3	339..431	CDD:394996	6/16 (38%)
		FN3	451..531	CDD:214495	24/116 (21%)
		EphA2_TM	569..642	CDD:464211	15/103 (15%)
		PTKc_EphR_A10	639..904	CDD:133195	90/289 (31%)
		SAM_superfamily	929..998	CDD:472832