DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Ephb1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_775623.3 Gene:Ephb1 / 270190 MGIID:1096337 Length:984 Species:Mus musculus


Alignment Length:636 Identity:161/636 - (25%)
Similarity:250/636 - (39%) Gaps:149/636 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 NRWTLTMEDLVPGDCG-------NYTCKVCNS--LGCIRHDTQVIVSDRVNHKPILMTGPLNLTL 210
            |..::.:|...|.:.|       |..||.|.:  ..|.|.|      |.|...|    ..|.||.
Mouse   334 NETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCD------DNVEFVP----RQLGLTE 388

  Fly   211 VVNSTGSM--HCKYLSDL------TSKKAWIFVPCHGMTNCSNN-----------------RSII 250
            ...|..|:  |..|..|:      :||..  |.|.|...|.:.|                 |||.
Mouse   389 CRVSISSLWAHTPYTFDIQAINGVSSKSP--FPPQHVSVNITTNQAAPSTVPIMHQVSATMRSIT 451

  Fly   251 AE--DKDQ-----LDFVNVRMEQEGWYTCVESNSLGQSNST---------AYLRVVRSLHVLEAG 299
            ..  ..:|     ||: .:|..::.......|.:..|:|:.         .|:..||:..|...|
Mouse   452 LSWPQPEQPNGIILDY-EIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYG 515

  Fly   300 VASGSL---------------HSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETV 349
            ..||.:               .....:......|::|:...........||..:.|......:..
Mouse   516 KFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAAYSDKLQ 580

  Fly   350 HQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPR- 413
            |..|           |..|..|...|.|..                     ||.|.::..|..: 
Mouse   581 HYST-----------GRGSPGMKIYIDPFT---------------------YEDPNEAVREFAKE 613

  Fly   414 ---SHLVLGATLGEGAFGRVVMAEV-----NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGR- 469
               |.:.:...:|.|.||.|....:     ....||:|.:|.|:::......:.|..:|   |: 
Mouse   614 IDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIM---GQF 675

  Fly   470 -HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDL 533
             |.|||.|.|..:::.|:.:|.|:..:|.|..||.:|         |..          .|...|
Mouse   676 DHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQN---------DGQ----------FTVIQL 721

  Fly   534 IKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQ---STDYYRKNTNGRL 595
            :.....||.||.||:....:||||||||:||:.:.|.|::||||:|.:|   |...|..:..|::
Mouse   722 VGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKI 786

  Fly   596 PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCS 660
            |::|.|||::..:.:.|.||||||||::||:|::|::|| ..||.:::...:....|:..|..|.
Mouse   787 PVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPY-WDMSNQDVINAIEQDYRLPPPMDCP 850

  Fly   661 MNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPS 711
            ..::.||..||..:.:.||.|.|||..:||:::.......|  |.:...||
Mouse   851 AALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTV--ATITAVPS 899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 11/44 (25%)
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 26/129 (20%)
Ig strand B 216..220 CDD:409353 1/5 (20%)
Ig strand C 229..233 CDD:409353 1/3 (33%)
Ig strand E 255..259 CDD:409353 2/8 (25%)
Ig strand F 269..274 CDD:409353 0/4 (0%)
Ig strand G 282..285 CDD:409353 1/11 (9%)
Protein Kinases, catalytic domain 404..692 CDD:473864 97/301 (32%)
Ephb1NP_775623.3 EphR_LBD_B1 20..195 CDD:198444
fn3 326..412 CDD:394996 22/87 (25%)
fn3 435..518 CDD:394996 15/83 (18%)
EphA2_TM 542..616 CDD:464211 16/105 (15%)
PTKc_EphR_B 614..882 CDD:173638 95/290 (33%)
SAM_EPH-B1 908..975 CDD:188950
PDZ-binding. /evidence=ECO:0000255 982..984
Blue background indicates that the domain is not in the aligned region.

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