Protein Alignment htl and ABL2

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Alignment Length: 595
• Identity: 164/595 - (27%)
• Similarity: 248/595 - (41%)
• Gaps: 137/595 - (23%)

  Fly   178 NSLGCIRHDTQVIVS--DRV---NHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPC 237
            |.||....|..:.|:  |.|   ::...:..|.....|..|..|..     |::.||....:||.
Human   100 NLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEW-----SEVRSKNGQGWVPS 159

  Fly   238 HGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQ------SNSTAYLRVVRSLHVL 296
            :.:|..::                  :|:..||....|.|..:      .|.:..:|...|
Human   160 NYITPVNS------------------LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESES---- 202

  Fly   297 EAGVASGSLHSTSFVYIF----VFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVI 357
            ..|..|.||.....||.:    ...|.:::...:.|...|.....|..|....:.|:|....|.
Human   203 SPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC- 266

  Fly   358 IFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATL 422
                                               |:|..:.  ..|:...||:.|:.:.:...|
Human   267 -----------------------------------NKPTVYG--VSPIHDKWEMERTDITMKHKL 294

  Fly   423 GEGAFGRVVMA--EVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGP 485
            |.|.:|.|.:.  :..:..||||.:||...  ::...::|..|||.| :|.|::.|||.|:...|
Human   295 GGGQYGEVYVGVWKKYSLTVAVKTLKEDTM--EVEEFLKEAAVMKEI-KHPNLVQLLGVCTLEPP 356

  Fly   486 LYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASR 550
            .|::.||.|:|||.|:|       |:.:|:.           :|...|:..|.||:..|:||..:
Human   357 FYIVTEYMPYGNLLDYL-------RECNREE-----------VTAVVLLYMATQISSAMEYLEKK 403

  Fly   551 RCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSD 615
            ..|||||||||.||.:::|:|:|||||:| :.:.|.|..:...:.||||.|||||....:..|||
Human   404 NFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSD 467

  Fly   616 VWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPP 680
            ||::|:|||||.|||..|||.| ...::|..|..|.|||:|..|...:|.|||.||.::..|||.
Human   468 VWAFGVLLWEIATYGMSPYPGI-DLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPS 531

  Fly   681 FTE------------------------------IVEYMDKL--LQTKEDYLDVDIANLDTPPSTS 713
            |.|                              :|.|:.:|  |.:|...|...:.|.:......
Human   532 FAETHQAFETMFHDSSISEEVAEELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQ 596

  Fly   714 DEEEDETDNL 723
            |..|:...:|
Human   597 DATENSASSL 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	4/12 (33%)
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	16/94 (17%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	2/4 (50%)
		Ig strand G	282..285	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	116/321 (36%)
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		CAP	2..106		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80
		SH3_Abl	111..164	CDD:212784	12/57 (21%)
		SH2_ABL	169..262	CDD:198189	21/96 (22%)
		PTKc_Abl	281..543	CDD:270645	112/284 (39%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674
		Nuclear localization signal. /evidence=ECO:0000255	658..660
		F-actin-binding. /evidence=ECO:0000250	694..930
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024
		F-actin-binding. /evidence=ECO:0000250	1020..1182
		FABD	1063..1182	CDD:197885