Protein Alignment htl and csk-1

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001293162.1
• Gene: csk-1 / 266817
• WormBaseID: WBGene00000812
• Length: 624
• Species: Caenorhabditis elegans
• Alignment Length: 684
• Identity: 179/684 - (26%)
• Similarity: 279/684 - (40%)
• Gaps: 170/684 - (24%)

  Fly   104 RNPKKMSFLQTRPSGSLLTLNCHALG--NPEPNITWYRNGTVD--------WTRGYGSLKRNRWT 158
            |||.|.|...       :....|:||  :..|..::..|...|        |.      :||...
 Worm    17 RNPTKFSNFS-------IEKRSHSLGGSSSSPTSSFSSNDEFDDRQNKNKFWR------QRNVSN 68

  Fly   159 LTMEDLVPGDCGNYTCKVCNS--------------LGCIRHDTQVIVSDRVN----HKPILMTGP 205
            ..:|.::.....|...|:.|.              :.|..|..|  ...|:|    ::.:|..|
 Worm    69 AEIERIIEDFIANGILKMSNGNSYNHHHQFPMSIPISCSSHSIQ--SQSRMNTLNANRDLLSPG- 130

  Fly   206 LNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNV--RMEQEG 268
             |..:|   |.::...:.|             |||....|   :..:|    |.|.:  ......
 Worm   131 -NDVIV---TRTVSPSFYS-------------HGMPARDN---VFRKD----DHVRILGNTTDPA 171

  Fly   269 WYTCVESNS-------------LGQSNSTAYLRVVRSLHVLEAGVAS-----GSLHSTSFVYIFV 315
            ||....:|.             .||:.....:|:..|...:..|.||     .|.|||:..:...
 Worm   172 WYRARNANQEEGLVHADCVVRINGQAYDNGIVRMRASGCDVAPGAASTTSSTSSHHSTAANHQPW 236

  Fly   316 FGGLIFIFMTTLFV------FYAIRKMK------------HEKVLKQRIETV------------- 349
            |..:|....|...:      .:.:|:..            |.||...|||..
 Worm   237 FHSMISRENTEKLLRGKPDGTFLVRESTNFPGDFTLCMSFHGKVEHYRIEQTSGGQLTCDKEEYF 301

  Fly   350 HQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNG-------------NEPAPFNEY 401
            ...|:.|..:|    .|:.|....::.|::   .:..|...||             :..:.|...
 Worm   302 SNLTQLVSHYK----RDADGLCHRLVTPII---CETATFSSNGSSSFGSSSTVDLEDRTSVFRHA 359

  Fly   402 EFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKI 466
            ...:.||      .:.:|.|:|.|.||.|.:....|..||:|:.|. |.:..:.||:.|.:.|
 Worm   360 GLVISSN------DIDVGDTIGHGEFGDVRLGTYKNRKVALKVSKR-HGNGMLDSLLDEAKFM-- 415

  Fly   467 IG-RHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITE 530
            :| .|.|::.|:|....:..:|:|.||..:|||.|.|   |..||               |.:..
 Worm   416 VGLSHPNLVTLVGVVLDDVNVYMITEYMANGNLIDLL---RSRGR---------------HALER 462

  Fly   531 KDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRL 595
            :.|:.||..|.:||.||.|::.:||||||||||:.||.|.|::|||||:...|..:  .:.:|:.
 Worm   463 RQLMMFAMDICQGMCYLESKQIVHRDLAARNVLLDDDLVAKVSDFGLAKKANSQSH--DSASGKF 525

  Fly   596 PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCS 660
            ||||.|||:|:...:.:||||||:|||||||.::|:.|||.| ..:::..|:..|.|||.|..|.
 Worm   526 PIKWTAPEALRHSQFTTKSDVWSFGILLWEIFSFGRVPYPRI-PIQDVVRYIEKGYRMEAPEGCP 589

  Fly   661 MNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQT 694
            ..|:.:|.:.|..:|.|||.|.::::.:..:..|
 Worm   590 PEIFKVMNETWALSAQDRPSFGQVLQRLTTIRNT 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	21/110 (19%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	18/103 (17%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	2/4 (50%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	108/288 (38%)
csk-1	NP_001293162.1	SH2_csk_like	232..330	CDD:198190	16/104 (15%)
		PTKc_Csk_like	362..620	CDD:270635	108/287 (38%)