DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Ror2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_038874.3 Gene:Ror2 / 26564 MGIID:1347521 Length:944 Species:Mus musculus


Alignment Length:768 Identity:186/768 - (24%)
Similarity:289/768 - (37%) Gaps:214/768 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 SSADLDDGAADD-----DDNKADLPVNVSSKPYWRNPKKMSFLQ-----TRPSGSLLTLNCHALG 129
            ::.:::|..|.|     |...:.||   :.|.|:.|     ||:     |...|....|:|...|
Mouse    31 TAGEVEDSEAIDTLGQPDGPDSPLP---TLKGYFLN-----FLEPVNNITIVQGQTAILHCKVAG 87

  Fly   130 NPEPNITWYRNG--TVDWTR-------GYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRH 185
            ||.||:.|.:|.  .|...|       .|||      .|.::||...|.|.|.|...|.|..|..
Mouse    88 NPPPNVRWLKNDAPVVQEPRRVIIRKTEYGS------RLRIQDLDTTDTGYYQCVATNGLKTITA 146

  Fly   186 DTQVIVSDRVNHKP-----------------------------------ILMTGPLN------LT 209
            ...:.|.....|.|                                   :.|.|.:.      .|
Mouse   147 TGVLYVRLGPTHSPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFT 211

  Fly   210 LVVNSTGSMHCKYLSDLTSKKA------WIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEG 268
            ::..||      .|||..|:.|      ::|..|...:.....|.:..::.:.|:  |....|| 
Mouse   212 MIGTST------QLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLE--NDLCRQE- 267

  Fly   269 WYTCVESNSL---------------GQSNSTAYLRVVRSLHVLEAGVAS---GSLHSTSFVYIFV 315
             ||...||.|               .:|...|        :.:..|:.:   |..|.     .:.
Mouse   268 -YTIARSNPLILMRLQLPKCEALPMPESPDAA--------NCMRIGIPAERLGRYHQ-----CYN 318

  Fly   316 FGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG-----DSSGSMD--- 372
            ..|..:..|.      :..|..|: .....::..|........|...|||     :..|.|:   
Mouse   319 GSGADYRGMA------STTKSGHQ-CQPWALQHPHSHRLSSTEFPELGGGHAYCRNPGGQMEGPW 376

  Fly   373 -----------------------------TMIMPVVRI---------------QKQR---TTVLQ 390
                                         .:::|.:.|               .||:   :|..:
Mouse   377 CFTQNKNVRVELCDVPPCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQR 441

  Fly   391 NGNEPAPFNEYEFPLDSNW------ELPRSHLVLGATLGEGAFGRVVMAEV-------NNAIVAV 442
            .....:|..:.|.||.|..      |:..|.:.....|||..||:|....:       ....||:
Mouse   442 RQLMASPSQDMEMPLISQHKQAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAI 506

  Fly   443 KMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP 507
            |.:|: ..:..:....|:..:::...:|.||:.|||..:::.||.:|..|..||:|.:||....|
Mouse   507 KTLKD-KAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSP 570

  Fly   508 F----GRDQDR--DSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSD 566
            .    ..|.||  .|:..||          |.:....|||.||::|:|...:|:|||.|||||.|
Mouse   571 HSDVGSTDDDRTVKSALEPP----------DFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYD 625

  Fly   567 DYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQ 631
            ...::|:|.||.|::.|.|||:...|..|||:||:||::....:...||:||||::|||:.:||.
Mouse   626 KLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGL 690

  Fly   632 QPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEI 684
            ||| ...|.:::...:.|.|.:..|..|...:|.||.:||:.....||.|.:|
Mouse   691 QPY-CGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 30/103 (29%)
Ig strand B 121..125 CDD:409353 1/3 (33%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 24/115 (21%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 1/9 (11%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 101/300 (34%)
Ror2NP_038874.3 I-set 64..152 CDD:400151 28/93 (30%)
Ig strand B 79..83 CDD:409570 1/3 (33%)
Ig strand C 92..96 CDD:409570 1/3 (33%)
Ig strand E 118..122 CDD:409570 2/9 (22%)
Ig strand F 132..137 CDD:409570 2/4 (50%)
Ig strand G 145..148 CDD:409570 0/2 (0%)
CRD_TK_ROR2 170..309 CDD:143577 25/156 (16%)
KR 314..395 CDD:214527 12/92 (13%)
Protein Kinases, catalytic domain 466..749 CDD:473864 98/289 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..779
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 850..879
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 898..929
Blue background indicates that the domain is not in the aligned region.

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