DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Hck

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_037317.2 Gene:Hck / 25734 RGDID:2785 Length:524 Species:Rattus norvegicus


Alignment Length:588 Identity:165/588 - (28%)
Similarity:249/588 - (42%) Gaps:140/588 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 CNSLGCIRHDTQV------------------IVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYL 223
            |...||.|.:.:|                  .:....|.|     ||:               |:
  Rat     7 CEDPGCPRGEGRVPRMGCVKSRFLREGSKASKIEPNANQK-----GPV---------------YV 51

  Fly   224 SDLTSKK-----AWIFVPCHGMTNCSNNRSIIA---------ED-----KDQLDFVNVRMEQEG- 268
            .|.||.|     :...:| .|:...|.:..::|         ||     .||:    |.:|:.| 
  Rat    52 PDPTSPKKLGPNSINSLP-PGVVEGSEDTIVVALYDYEAIHREDLSFQKGDQM----VVLEESGE 111

  Fly   269 WYTCVESNSLGQSNS----TAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFV 329
            |:   ::.||.....    :.|:..|.||.. |.....|.....:..::...|.::..||     
  Rat   112 WW---KARSLATKKEGYIPSNYVARVNSLET-EEWFFKGISRKDAERHLLAPGNMLGSFM----- 167

  Fly   330 FYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG----------DSSG-------SMDTMIMP 377
                        ::....|...::..|..|.|:.|.          ||.|       :..::...
  Rat   168 ------------IRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQEL 220

  Fly   378 VVRIQKQRTTVLQNGNEPAPFNEYEFPLDSN-WELPRSHLVLGATLGEGAFGRVVMAEVN-NAIV 440
            ||..:|.:..:.|..:.|....:.:.|.:.: ||:||..|.:...||.|.||.|.||..| :..|
  Rat   221 VVHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKV 285

  Fly   441 AVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKN 505
            |||.:|.|..  .:.:.:.|..:||.: :|..::.|....||. |::::.|:...|:|.|||   
  Rat   286 AVKTMKPGSM--SVEAFLAEANLMKTL-QHDKLVKLHAVVSQE-PIFIVTEFMAKGSLLDFL--- 343

  Fly   506 RPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVL 570
                 ..:..|.||.|.          ||.|:.||:.||.::..|..|||||.|.|:|||...|.
  Rat   344 -----KSEEGSKQPLPK----------LIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVC 393

  Fly   571 KIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYP 635
            |||||||||.|:..:|..:. ..:.||||.|||::....:..||||||:||||.||:|||:.|||
  Rat   394 KIADFGLARIIEDNEYTARE-GAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYP 457

  Fly   636 TIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ-----TK 695
            . ||..|:...|..|.||.:|..|...:|.:|.:||....::||.|    ||:..:|.     |:
  Rat   458 G-MSNPEVIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEERPTF----EYIQSVLDDFYTATE 517

  Fly   696 EDY 698
            ..|
  Rat   518 SQY 520

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 5/31 (16%)
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 22/112 (20%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 1/8 (13%)
Ig strand E 255..259 CDD:409353 2/3 (67%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/6 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 112/289 (39%)
HckNP_037317.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 4/12 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..71 10/56 (18%)
SH3 80..135 CDD:473055 12/61 (20%)
SH2_Src_HCK 138..241 CDD:198226 18/120 (15%)
Protein Kinases, catalytic domain 252..522 CDD:473864 114/297 (38%)
Blue background indicates that the domain is not in the aligned region.

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