DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Igf1r

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_008757722.1 Gene:Igf1r / 25718 RGDID:2869 Length:1372 Species:Rattus norvegicus


Alignment Length:506 Identity:151/506 - (29%)
Similarity:231/506 - (45%) Gaps:108/506 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 KDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYI----- 313
            :||.:.|: |.|... |...:.|.|...|.||.::.. ||.      .:||.....|.|:     
  Rat   876 EDQRECVS-RQEYRK-YGGAKLNRLNPGNYTARIQAT-SLS------GNGSWTDPVFFYVPAKTT 931

  Fly   314 ----------------FVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPE 362
                            .:.|||:.:    |:||:  ||..:.::                     
  Rat   932 YENFMHLIIALPVAILLIVGGLVIM----LYVFH--RKRNNSRL--------------------- 969

  Fly   363 GGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAF 427
            |.|                      ||.....|..|:..:..:...||:.|..:.:...||:|:|
  Rat   970 GNG----------------------VLYASVNPEYFSAADVYVPDEWEVAREKITMNRELGQGSF 1012

  Fly   428 GRV-------VMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGP 485
            |.|       |:.:.....||:|.|.|..:..:....:.|..|||....| :::.|||..||..|
  Rat  1013 GMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQP 1076

  Fly   486 LYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASR 550
            ..||:|....|:||.:|...||  ..:..:....|||       ...:|:.|.:||.||.||.:.
  Rat  1077 TLVIMELMTRGDLKSYLRSLRP--EVEQNNLVLIPPS-------LSKMIQMAGEIADGMAYLNAN 1132

  Fly   551 RCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSD 615
            :.:||||||||.:|::|:.:||.|||:.|||..||||||...|.||::||:||||::..:.:.||
  Rat  1133 KFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSD 1197

  Fly   616 VWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPP 680
            |||:|::||||.|..:|||.. :|.|::..::|.|..::||..|...::.|||.||.:|...||.
  Rat  1198 VWSFGVVLWEIATLAEQPYQG-LSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPS 1261

  Fly   681 FTEIV----EYMDKLLQTKEDYLDVDIANLDTPPSTSD---EEEDETDNLQ 724
            |.||:    :.|:...|....|...:    :.||...:   |.|.|.:|::
  Rat  1262 FLEIIGSIKDEMEPSFQEVSFYYSEE----NKPPEPEELEMELELEPENME 1308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250 11/34 (32%)
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353 2/3 (67%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 112/298 (38%)
Igf1rXP_008757722.1 Recep_L_domain 51..161 CDD:460032
Furin-like 175..330 CDD:395614
Recep_L_domain 353..468 CDD:460032
FN3 494..607 CDD:238020
FN3 612..>656 CDD:238020
FN3 837..926 CDD:238020 16/58 (28%)
PTKc_InsR_like 994..1271 CDD:173625 111/287 (39%)
Blue background indicates that the domain is not in the aligned region.

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