DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Pdgfra

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_036934.1 Gene:Pdgfra / 25267 RGDID:3284 Length:1088 Species:Rattus norvegicus


Alignment Length:774 Identity:214/774 - (27%)
Similarity:316/774 - (40%) Gaps:242/774 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   111 FLQTRPS-GSLLTLNCHAL--------GNPEPNITWYRNG----------TVDWTRGYGSLKRNR 156
            |:|.||: |.|.|:|.|.:        ..|.|.|:|.::.          |.|..|...:..:::
  Rat   313 FVQIRPTFGHLETVNLHQVREFVVEVQAYPTPRISWLKDNLTLIENLTEITTDVQRSQETRYQSK 377

  Fly   157 WTL--TMEDLVPGDCGNYTCKVCN--SLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGS 217
            ..|  ..|:    |.|:||..|.|  .:.....:...:|...:            |.||.:..||
  Rat   378 LKLIRAKEE----DSGHYTIIVQNDDDMKSYTFELSTLVPASI------------LELVDDHHGS 426

  Fly   218 --------------------MHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAE--------DK 254
                                |.||.:....:..:|..:       .||..:||.|        .:
  Rat   427 GGGQTVRCTAEGTPLPNIEWMICKDIKKCNNDTSWTVL-------ASNVSNIITEFHQRGRSTVE 484

  Fly   255 DQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGL 319
            .::.|..|  |:.....|:..|.||..|..  |::|......|..||:..|            .|
  Rat   485 GRVSFAKV--EETIAVRCLAKNDLGIGNRE--LKLVAPTLRSELTVAAAVL------------VL 533

  Fly   320 IFIFMTTLFVFYAIRKMKHEKVLKQR-IETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQK 383
            :.|.:.:|.|...|.|.|....::.| ||::          .|:|                    
  Rat   534 LVIVIVSLIVLVVIWKQKPRYEIRWRVIESI----------SPDG-------------------- 568

  Fly   384 QRTTVLQNGNEPAPFNEY------EFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI--- 439
                           :||      :.|.||.||.||..||||..||.||||:||........   
  Rat   569 ---------------HEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQ 618

  Fly   440 ----VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKD 500
                |||||:|......:..:|:.|:::|..:|.|:||:||||.|:::||:|:|.||..:|:|.:
  Rat   619 PVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVN 683

  Fly   501 FLYKNRP----------------FGRD-----------------------QDRDSSQPPP----- 521
            :|:|||.                ||.:                       :..|::|..|     
  Rat   684 YLHKNRDSFMSRHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYVDMKQADTTQYVPMLERK 748

  Fly   522 -------------SPPAHV---------------------ITEKDLIKFAHQIARGMDYLASRRC 552
                         ..||..                     :|..||:.|.:|:||||::|||:.|
  Rat   749 EVSKYSDIQRSLYDRPASYKKKSMLDSEAKNLLSDDDSEGLTLLDLLSFTYQVARGMEFLASKNC 813

  Fly   553 IHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVW 617
            :||||||||||::...::||.||||||||.....|....:..||:|||||||:.:..|.:.||||
  Rat   814 VHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVW 878

  Fly   618 SYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFT 682
            |||:|||||.:.|..|||.:|.....|..:.||.||.||...:..:|.:|.|||:...:.||.|.
  Rat   879 SYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFY 943

  Fly   683 EIVEYMDKLL--QTKEDY--LDVDIANLDTPPST-----SDEE------EDETDNLQKW 726
            .:.|.::.||  |.|:.|  :.:|....|.|...     ||..      ::|.|.|::|
  Rat   944 HLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKEW 1002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 23/101 (23%)
IG_like 113..191 CDD:214653 23/100 (23%)
IG_like 205..289 CDD:214653 23/111 (21%)
PKc_like 404..692 CDD:304357 133/372 (36%)
STYKc 416..688 CDD:214568 126/356 (35%)
PdgfraNP_036934.1 Ig_3 27..99 CDD:404760
Ig 211..309 CDD:416386
Ig strand A 211..215 CDD:409353
Ig strand A' 222..226 CDD:409353
Ig strand B 228..237 CDD:409353
Ig strand C 242..247 CDD:409353
Ig strand C' 250..252 CDD:409353
Ig strand D 256..264 CDD:409353
Ig strand E 268..276 CDD:409353
Ig strand F 286..292 CDD:409353
Ig strand G 297..303 CDD:409353
Ig4_PDGFR 312..412 CDD:409445 24/102 (24%)
Ig strand B 332..336 CDD:409445 0/3 (0%)
Ig strand C 345..349 CDD:409445 1/3 (33%)
Ig strand E 376..380 CDD:409445 0/3 (0%)
Ig strand F 390..395 CDD:409445 2/4 (50%)
Ig strand G 403..406 CDD:409445 0/2 (0%)
PTKc_PDGFR_alpha 554..955 CDD:173653 142/445 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1017..1088
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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