Protein Alignment htl and Pdgfra

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_038947553.2
• Gene: Pdgfra / 25267
• RGDID: 3284
• Length: 1111
• Species: Rattus norvegicus
• Alignment Length: 774
• Identity: 214/774 - (27%)
• Similarity: 316/774 - (40%)
• Gaps: 242/774 - (31%)

  Fly   111 FLQTRPS-GSLLTLNCHAL--------GNPEPNITWYRNG----------TVDWTRGYGSLKRNR 156
            |:|.||: |.|.|:|.|.:        ..|.|.|:|.::.          |.|..|...:..:::
  Rat   336 FVQIRPTFGHLETVNLHQVREFVVEVQAYPTPRISWLKDNLTLIENLTEITTDVQRSQETRYQSK 400

  Fly   157 WTL--TMEDLVPGDCGNYTCKVCN--SLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGS 217
            ..|  ..|:    |.|:||..|.|  .:.....:...:|...:            |.||.:..||
  Rat   401 LKLIRAKEE----DSGHYTIIVQNDDDMKSYTFELSTLVPASI------------LELVDDHHGS 449

  Fly   218 --------------------MHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAE--------DK 254
                                |.||.:....:..:|..:       .||..:||.|        .:
  Rat   450 GGGQTVRCTAEGTPLPNIEWMICKDIKKCNNDTSWTVL-------ASNVSNIITEFHQRGRSTVE 507

  Fly   255 DQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGL 319
            .::.|..|  |:.....|:..|.||..|..  |::|......|..||:..|            .|
  Rat   508 GRVSFAKV--EETIAVRCLAKNDLGIGNRE--LKLVAPTLRSELTVAAAVL------------VL 556

  Fly   320 IFIFMTTLFVFYAIRKMKHEKVLKQR-IETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQK 383
            :.|.:.:|.|...|.|.|....::.| ||::          .|:|
  Rat   557 LVIVIVSLIVLVVIWKQKPRYEIRWRVIESI----------SPDG-------------------- 591

  Fly   384 QRTTVLQNGNEPAPFNEY------EFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI--- 439
                           :||      :.|.||.||.||..||||..||.||||:||........
  Rat   592 ---------------HEYIYVDPMQLPYDSRWEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRSQ 641

  Fly   440 ----VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKD 500
                |||||:|......:..:|:.|:::|..:|.|:||:||||.|:::||:|:|.||..:|:|.:
  Rat   642 PVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVN 706

  Fly   501 FLYKNRP----------------FGRD-----------------------QDRDSSQPPP----- 521
            :|:|||.                ||.:                       :..|::|..|
  Rat   707 YLHKNRDSFMSRHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYVDMKQADTTQYVPMLERK 771

  Fly   522 -------------SPPAHV---------------------ITEKDLIKFAHQIARGMDYLASRRC 552
                         ..||..                     :|..||:.|.:|:||||::|||:.|
  Rat   772 EVSKYSDIQRSLYDRPASYKKKSMLDSEAKNLLSDDDSEGLTLLDLLSFTYQVARGMEFLASKNC 836

  Fly   553 IHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVW 617
            :||||||||||::...::||.||||||||.....|....:..||:|||||||:.:..|.:.||||
  Rat   837 VHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVW 901

  Fly   618 SYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFT 682
            |||:|||||.:.|..|||.:|.....|..:.||.||.||...:..:|.:|.|||:...:.||.|.
  Rat   902 SYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFY 966

  Fly   683 EIVEYMDKLL--QTKEDY--LDVDIANLDTPPST-----SDEE------EDETDNLQKW 726
            .:.|.::.||  |.|:.|  :.:|....|.|...     ||..      ::|.|.|::|
  Rat   967 HLSEIVENLLPGQYKKSYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKEW 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	24/102 (24%)
		Ig strand B	121..125	CDD:409353	1/3 (33%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	1/5 (20%)
		Ig strand F	171..176	CDD:409353	2/4 (50%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	23/116 (20%)
		Ig strand B	216..220	CDD:409353	3/23 (13%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	133/372 (36%)
Pdgfra	XP_038947553.2	None