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Protein Alignment htl and Fgfr4

DIOPT Version :10

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_006253668.1	Gene:	Fgfr4 / 25114	RGDID:	2612	Length:	801	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	279/705 - (39%)
Similarity:	377/705 - (53%)	Gaps:	67/705 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 MANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPK 107
            :|.....:..:|.....:..|:|.|...::.:||:   .|.:           .:...|||.:|:
  Rat    99 LARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSS---SGHS-----------YLQQAPYWTHPQ 149

  Fly   108 KM-SFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTV---DWTRGYGSLKRNRWTLTMEDLVPGD 168
            :| ..|...|:|:.:...|.|.|||.|.|.|.:||..   :...|...|:...|:|.||.:||.|
  Rat   150 RMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSD 214

  Fly   169 CGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAW 232
            .|.|||.|.||||.||:...:.|.:|..|:|||..| |.|.|.||.|...:.||..||......|
  Rat   215 RGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQW 279

  Fly   233 IFVPCHGMTNCSN-------------NRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNST 284
            :   .|.:.|.|:             ...|.:.:.:.|...||..|..|.|||:..||:|.|..:
  Rat   280 L---KHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQS 341

  Fly   285 AYLRVVRSLHV--LEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIE 347
            |:|.|:.....  |....|:.....|..: ::|.|.|..:.:..|...|. |:..|....:|.:
  Rat   342 AWLTVLPEAEEEDLAWTTATSEARYTDII-LYVSGSLALVLLLLLAGVYH-RQAIHGHHSRQPV- 403

  Fly   348 TVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELP 412
            ||.:.::..:..:......|||.....::..||:......:|..      ....:.|||..||.|
  Rat   404 TVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTG------LVSLDLPLDPLWEFP 462

  Fly   413 RSHLVLGATLGEGAFGRVVMAEV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIG 468
            |..||||..||||.||:||.||.         ..:.|||||:|:..:|.|:|.|:.|||:||:||
  Rat   463 RDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIG 527

  Fly   469 RHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRD---SSQPPPSPPAHVITE 530
            ||.|||||||.|:|.||||||||||..|||::||...||.|.|...|   ||:.|.|.||
  Rat   528 RHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPA----- 587

  Fly   531 KDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRL 595
              |:..|:|:||||.||.||:|||||||||||||::|.|:|||||||||.:...|||:|.:||||
  Rat   588 --LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRL 650

  Fly   596 PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCS 660
            |:||||||:|.::.|..:|||||:|||||||.|.|..|||.| ..|||::.|..|.|||:|..|.
  Rat   651 PVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMERPPNCP 714

  Fly   661 MNIYILMRQCWHFNADDRPPFTEIVEYMDK-LLQTKEDYLDVDIANLDTPPSTSD 714
            ..:|.|||:|||.....||.|.::||.:|| ||...|:|||:.:......|:..|
  Rat   715 SELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGD 769

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.