DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and Ntrk2

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_008769647.1 Gene:Ntrk2 / 25054 RGDID:3213 Length:837 Species:Rattus norvegicus


Alignment Length:707 Identity:175/707 - (24%)
Similarity:301/707 - (42%) Gaps:160/707 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 MIKDHLGARSQNK-TPAITN-NANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSF 111
            ::..|:...|..: :..||| :::.|....:.:.:....:|.:..:|.|:.:        ..::|
  Rat   235 LVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFA--------PTITF 291

  Fly   112 LQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKV 176
            |::..|.....:.....|||:|.:.|:.||.:        |..:::..|...:.     |:|   
  Rat   292 LESPTSDHHWCIPFTVRGNPKPALQWFYNGAI--------LNESKYICTKIHVT-----NHT--- 340

  Fly   177 CNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGM- 240
             ...||::.|....:::.            :.||:..:      :|..|...      :..|.| 
  Rat   341 -EYHGCLQLDNPTHMNNG------------DYTLMAKN------EYGKDERQ------ISAHFMG 380

  Fly   241 -------TNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEA 298
                   || .|...::.||               |.|   ...:|.:.:       :|..:...
  Rat   381 RPGVDYETN-PNYPEVLYED---------------WTT---PTDIGDTTN-------KSNEIPST 419

  Fly   299 GVASGSLHSTSFVY-IFVFGGLI-FIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKP 361
            .||..:......|| :.|...:: |..:..|.:   ::..:|.|...:.:    .|.....:...
  Rat   420 DVADQTNREHLSVYAVVVIASVVGFCLLVMLLL---LKLARHSKFGMKDV----SWFGIGKVKSR 477

  Fly   362 EGGG--------------------------DSSGSMDTMIMPVVRIQKQRTTVLQNGN------- 393
            :|.|                          .|.|..|.:|:.:.:|     .|::|..       
  Rat   478 QGVGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKI-----PVIENPQYFGITNS 537

  Fly   394 --EPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNN-------AIVAVKMVKEGH 449
              :|..|.::         :.|.::||...|||||||:|.:||..|       .:||||.:|:. 
  Rat   538 QLKPDTFVQH---------IKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDA- 592

  Fly   450 TDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDR 514
            :|:......||.|::..: :|.:|:...|.|.:..||.::.||..||:|..||   |..|.|...
  Rat   593 SDNARKDFHREAELLTNL-QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFL---RAHGPDAVL 653

  Fly   515 DSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR 579
            .:...||:.    :|:..::..|.|||.||.||||:..:|||||.||.||.::.::||.|||::|
  Rat   654 MAEGNPPTE----LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSR 714

  Fly   580 DIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELY 644
            |:.||||||...:..|||:||.|||:..:.:.::|||||.|::||||.|||:||:.. :|..|:.
  Rat   715 DVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ-LSNNEVI 778

  Fly   645 TYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDV 701
            ..:..|:.:::|..|...:|.||..||......|.....|...:..|.:....|||:
  Rat   779 ECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDI 835

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 17/89 (19%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 2/4 (50%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 14/96 (15%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 109/294 (37%)
Ntrk2XP_008769647.1 LRR_8 92..150 CDD:404697
LRRCT_2 151..195 CDD:465313
Ig 205..283 CDD:472250 8/47 (17%)
Ig strand B 214..218 CDD:409390
Ig strand C 227..230 CDD:409390
Ig strand E 245..252 CDD:409390 0/6 (0%)
Ig strand F 262..268 CDD:409390 0/5 (0%)
Ig strand G 276..279 CDD:409390 0/2 (0%)
IgI_TrkB_d5 286..379 CDD:409441 22/141 (16%)
Ig strand A 286..294 CDD:409441 2/15 (13%)
Ig strand A' 295..298 CDD:409441 0/2 (0%)
Ig strand B 301..309 CDD:409441 0/7 (0%)
Ig strand C 312..319 CDD:409441 2/6 (33%)
Ig strand C' 322..325 CDD:409441 0/10 (0%)
Ig strand D 330..335 CDD:409441 1/4 (25%)
Ig strand E 341..349 CDD:409441 2/7 (29%)
Ig strand F 357..365 CDD:409441 2/19 (11%)
Ig strand G 368..376 CDD:409441 1/13 (8%)
PTKc_TrkB 547..834 CDD:270675 111/305 (36%)
Blue background indicates that the domain is not in the aligned region.

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