DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Fgfr2

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_036844.1	Gene:	Fgfr2 / 25022	RGDID:	2611	Length:	841	Species:	Rattus norvegicus

Alignment Length:	810	Identity:	295/810 - (36%)
Similarity:	419/810 - (51%)	Gaps:	137/810 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SWR----ASHSTITMTS-GSLVVLFLL----LSIWQPAVQ-VEG----------RRQMANSQE-- 48
            :||    ....|:||.| |..:.|.|:    ||:.:|:.. ||.          :.|::..:.
  Rat     6 TWRYGTGPGIGTVTMVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEACV 70

  Fly    49 -----------MIKD-----------HLGARS-----------QNKTPAITN------------- 67
                       |:||           |||..:           :..||..:.
  Rat    71 VAPGESLELRCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACAAARTVDSE 135

  Fly    68 ------NANQSSTSSADLDDGAADDD---DNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLT 122
                  |...:.:|..|.||..:.:|   :|:::     ...|||.|.:|| ..|...|:.:.:.
  Rat   136 TLYFMVNVTDAISSGDDEDDTDSSEDFVSENRSN-----QRAPYWTNTEKMEKRLHAVPAANTVK 195

  Fly   123 LNCHALGNPEPNITWYRNGTVDWTR-----GYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGC 182
            ..|.|.|||.|.:.|.:||. ::.:     || .::...|:|.||.:||.|.|||||.|.|..|.
  Rat   196 FRCPAGGNPTPTMRWLKNGK-EFKQEHRIGGY-KVRNQHWSLIMESVVPSDKGNYTCLVENEYGS 258

  Fly   183 IRHDTQVIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCS-- 244
            |.|...:.|.:|..|:|||..| |.|.:.||.......||..||......||   .|...|.|
  Rat   259 INHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI---KHVEKNGSKY 320

  Fly   245 -----------NNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVV--RSLHVL 296
                       .:..|.:.:.:.|...||.....|.|.|..||.:||:|.:|:|.|:  :...|.
  Rat   321 GPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAPVR 385

  Fly   297 EAGVASGSLHSTSFVYIFVFG-GLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFK 360
            |..:.:    |..::.|.::. |:..|....:.|.:...|...:|........||:.||::.:.:
  Rat   386 EKEITA----SPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRR 446

  Fly   361 P-EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATL 422
            . ....:||.||::. .|:|||   .|.:....:.|  |..:|||.|.|..||.||..|.||..|
  Rat   447 QVTVSAESSSSMNSN-TPLVRI---TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPL 507

  Fly   423 GEGAFGRVVMAEV--------NNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLG 478
            |||.||:|||||.        ..|: |||||:|:..|:.|::.||.|||:||:||:|.|||||||
  Rat   508 GEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLG 572

  Fly   479 CCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARG 543
            .|:|:||||||||||..|||:::|...||.|.:...|.::.|...    :|.|||:...:|:|||
  Rat   573 ACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ----MTFKDLVSCTYQLARG 633

  Fly   544 MDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEK 608
            |:||||::|||||||||||||:::.|:|||||||||||.:.|||:|.||||||:||||||:|.::
  Rat   634 MEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDR 698

  Fly   609 FYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHF 673
            .|..:|||||:|:|:|||.|.|..|||.| ..|||:..|..|.||:||..|:..:|::||.|||.
  Rat   699 VYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHA 762

  Fly   674 NADDRPPFTEIVEYMDKL--LQTKEDYLDV 701
            ....||.|.::||.:|::  |.|.|:|||:
  Rat   763 VPSQRPTFKQLVEDLDRILTLTTNEEYLDL 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	30/83 (36%)
		IG_like	113..191	CDD:214653	29/82 (35%)
		IG_like	205..289	CDD:214653	27/96 (28%)
		PKc_like	404..692	CDD:304357	161/298 (54%)
		STYKc	416..688	CDD:214568	154/280 (55%)
Fgfr2	NP_036844.1	Ig	50..143	CDD:416386	9/92 (10%)
		Ig strand A	50..53	CDD:409353	0/2 (0%)
		Ig strand A'	66..72	CDD:409353	0/5 (0%)
		Ig strand B	75..85	CDD:409353	1/9 (11%)
		Ig strand C	88..93	CDD:409353	0/4 (0%)
		Ig strand C'	96..98	CDD:409353	0/1 (0%)
		Ig strand D	103..107	CDD:409353	0/3 (0%)
		Ig strand E	110..115	CDD:409353	0/4 (0%)
		Ig strand F	121..130	CDD:409353	0/8 (0%)
		Ig strand G	133..143	CDD:409353	0/9 (0%)
		IgI_2_FGFR	173..267	CDD:409443	36/95 (38%)
		Ig strand B	194..198	CDD:409443	0/3 (0%)
		Ig strand C	207..211	CDD:409443	0/3 (0%)
		Ig strand E	233..237	CDD:409443	2/3 (67%)
		Ig strand F	247..252	CDD:409443	4/4 (100%)
		Ig strand G	260..263	CDD:409443	1/2 (50%)
		Ig	275..377	CDD:416386	31/104 (30%)
		Ig strand A	275..278	CDD:409353	2/2 (100%)
		Ig strand A'	282..286	CDD:409353	2/3 (67%)
		Ig strand B	294..301	CDD:409353	2/6 (33%)
		Ig strand C	305..312	CDD:409353	2/9 (22%)
		Ig strand D	327..332	CDD:409353	0/4 (0%)
		Ig strand E	342..347	CDD:409353	1/4 (25%)
		Ig strand F	355..363	CDD:409353	3/7 (43%)
		Ig strand G	366..374	CDD:409353	4/7 (57%)
		FGFR3_TM	391..421	CDD:407957	5/33 (15%)
		PTKc_FGFR2	476..788	CDD:270679	168/316 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1150
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1477
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm9075
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740