DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and Pdgfrb

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_113713.1	Gene:	Pdgfrb / 24629	RGDID:	3285	Length:	1097	Species:	Rattus norvegicus

Alignment Length:	847	Identity:	226/847 - (26%)
Similarity:	332/847 - (39%)	Gaps:	297/847 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 GSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPG--------------- 167
            |..:|:.|..:||...|..|          .|..:|..|....:.|.:.|
  Rat   227 GESITIRCIVMGNDVVNFQW----------TYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAE 281

  Fly   168 --DCGNYTCKVCNSL----------------GCIR-----HDTQVIVSDR---------VNHKPI 200
              |.|.|||.|..|:                |.:|     .|.|:....|         ....|.
  Rat   282 LSDSGTYTCNVSVSVNDHGDEKAINVTVIENGYVRLLETLEDVQIAELHRSRTLQVVFEAYPTPS 346

  Fly   201 LMTGPLNLTLVVNSTGSM--------HCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQL 257
            ::....|.||..:|.|.:        ..:|:|:||..:..:     ........|:..|:|:.||
  Rat   347 VLWFKDNRTLGDSSAGELVLSTRNVSETRYVSELTLVRVKV-----SEAGYYTMRAFHADDQVQL 406

  Fly   258 DF---VNV-------------------RMEQEG-------WYTC---------VESNSLGQSN-- 282
            .|   |||                   |....|       |.||         :....||.|:
  Rat   407 SFKLQVNVPVRVLELSESHPANGEQILRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTPLGNSSKE 471

  Fly   283 --------------------STAYLR-VVRSLHV---LEAGVASGSL------HSTSFVYIFVFG 317
                                ||..|| |.:.|.|   |:..:...|.      ||..|..:.:..
  Rat   472 ESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGRDSQEVTVVPHSLPFKVVVISA 536

  Fly   318 GLIFIFMTTLFVFYAI----RKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPV 378
            .|..:.:|.:.:...|    ||.::|          .:|  |||
  Rat   537 ILALVVLTVISLIILIMLWQRKPRYE----------IRW--KVI--------------------- 568

  Fly   379 VRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI---- 439
                   .:|..:|:|....:..:.|.||.|||||..||||.|||.||||:||.|..:...
  Rat   569 -------ESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQA 626

  Fly   440 ---VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDF 501
               |||||:|......:..:|:.|:::|..:|.|:|::||||.|::.||:|:|.||..:|:|.|:
  Rat   627 TMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDY 691

  Fly   502 LYKNR-----------------------PFG-----------------RDQDRDSS--------- 517
            |::|:                       |.|                 .|..:|.|
  Rat   692 LHRNKHTFLQRHSNKHCPPSTELYSNALPVGLSLPSHLNLTGESDGGYMDMSKDESVDYVPMLDM 756

  Fly   518 --------------QPP-----PSPP-----------AHVITEKDLIKFAHQIARGMDYLASRRC 552
                          ..|     ||.|           :.|::..||:.|::|:|.||::|||:.|
  Rat   757 KGHIKYADIESSSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMEFLASKNC 821

  Fly   553 IHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVW 617
            :||||||||||:.:..::||.||||||||.....|....:..||:|||||||:....|.:.||||
  Rat   822 VHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVW 886

  Fly   618 SYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFT 682
            |:|||||||.|.|..|||.:...::.|..:..|.||.:||..|..||.:|::||....:.||||:
  Rat   887 SFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFS 951

  Fly   683 EIVEYMDKLL---------QTKEDYLDVD-------------IANLDTPPSTSD-----EEEDET 720
            ::|..:::||         |..|::|..|             :.:|.:|..||.     .:.:||
  Rat   952 QLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGLHSLRSPLDTSSVLYTAVQPNET 1016

  Fly   721 DN 722
            ||
  Rat  1017 DN 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	23/110 (21%)
		IG_like	113..191	CDD:214653	23/110 (21%)
		IG_like	205..289	CDD:214653	30/152 (20%)
		PKc_like	404..692	CDD:304357	136/373 (36%)
		STYKc	416..688	CDD:214568	128/357 (36%)
Pdgfrb	NP_113713.1	ig	36..113	CDD:395002
		Ig strand B	49..53	CDD:409353
		Ig strand C	59..62	CDD:409353
		Ig strand E	82..86	CDD:409353
		Ig strand F	96..101	CDD:409353
		Ig	211..309	CDD:416386	19/91 (21%)
		Ig strand A	211..215	CDD:409353
		Ig strand A'	222..226	CDD:409353
		Ig strand B	228..237	CDD:409353	2/8 (25%)
		Ig strand C	242..247	CDD:409353	2/14 (14%)
		Ig strand C'	250..252	CDD:409353	0/1 (0%)
		Ig strand D	256..264	CDD:409353	1/7 (14%)
		Ig strand E	270..277	CDD:409353	0/6 (0%)
		Ig strand F	287..293	CDD:409353	3/5 (60%)
		Ig strand G	298..304	CDD:409353	0/5 (0%)
		Ig	313..414	CDD:416386	22/105 (21%)
		PKc_like	561..952	CDD:419665	143/430 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1097		3/3 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910