DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and igf1rb

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_694501.1 Gene:igf1rb / 245702 ZFINID:ZDB-GENE-020503-2 Length:1380 Species:Danio rerio


Alignment Length:944 Identity:226/944 - (23%)
Similarity:349/944 - (36%) Gaps:301/944 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WSWRASHSTITMTSGSLVVLFLLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNA 69
            |.|  |...:|::.|.|  .|.|    .|.:.:...|:|. ::..|||:...|.      ..||.
Zfish   418 WDW--SQHNLTISEGKL--YFRL----NPKLCMSEIRKMW-AKTGIKDNFVERD------FRNNG 467

  Fly    70 NQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKMSFLQTRPSGS--LLTLNCHALGNPE 132
            :::|..:..|                ..:|.....|..|:.:...|||.|  |:....:....|.
Zfish   468 DRASCGTKIL----------------KFTSNNTRSNQIKLMWESYRPSDSRDLVNFIVYYKEAPF 516

  Fly   133 PNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNS---LGCIRHDTQ------ 188
            .|||.:        .|..|...:.|.:...|| |.:      |:.|.   |..::..||      
Zfish   517 QNITEF--------DGQDSCGSDSWDMVNVDL-PDE------KILNPGVVLSTLKPWTQYAIFVK 566

  Fly   189 ---VIVSDR-----------------VNHKPILMTGPLNLTLVVNSTGSMHCK------------ 221
               :||.||                 :..||...:.|:::....||:..:..:            
Zfish   567 AVTLIVEDRDRDKDRLHLGPQSEVVYIRTKPSAPSMPVDIRAYANSSSKLVVRWAPPLAPNGNNT 631

  Fly   222 ---------------YLSDLTSK--KAWIFVPCHGMTNCSNNRSIIAE------------DKDQL 257
                           |..:..||  |..:.|...|:|:..:.:....|            .|.:.
Zfish   632 YYVLRWKQQGEDRELYQHNYCSKELKIPVRVSATGLTDTEDTKPTYHETGGRDKTPCCPCPKTEE 696

  Fly   258 DFVNVRMEQEGWYTCVESNSL------------------GQSNSTAYLRVVRSLHVLEAG---VA 301
            |.  .|:|.:.:|.....|.|                  |.:|       |.|:|.|.||   :.
Zfish   697 DL--KRIEDDIYYRKAFENFLHNAIFTPRPPDRRRRDLFGVAN-------VTSIHTLLAGHWNLT 752

  Fly   302 SGSL-------HSTSFV-------YIFVFG----------------------GLIFIFMTT---- 326
            .|:.       ...||:       :|.:.|                      ...|:|..|    
Zfish   753 EGNFSDDEPPRREFSFLERKVKERHIEITGLQPFTVYRIDLHACNEEVRHCSAAAFVFSRTKAAE 817

  Fly   327 ------------------------------LFVFYAIR------KMKHEKVLKQRIETVHQWTKK 355
                                          |.:.|.|:      ..|||.|.:|     |....|
Zfish   818 KADDIPGSVTWEGQEDSVFLKWPEPDKPNGLIMLYEIQYRLGTEPEKHECVSRQ-----HYRKHK 877

  Fly   356 VIIFKPEGGGDSS-----------GS--------------------MDTMIMPVVRI-------- 381
            .:.....|.|:.|           ||                    |...|:|.:.:        
Zfish   878 GVKLSNLGPGNYSVRVRATSLAGNGSWTEPIAFSVHQLEQSSYDPVMFIAILPALLLIAGLVVFG 942

  Fly   382 ----QKQRTT------VLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRV------ 430
                .|.|..      ||.....|..|:..|..:...||:.|..:.:...||:|:||.|      
Zfish   943 YTWMNKNRNNDRLGNGVLYASVNPEYFSAAEMYVPDEWEVEREKITMCRELGQGSFGMVYEGIAK 1007

  Fly   431 -VMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAP 494
             |:.:.....||:|.|.|..:..:....:.|..|||....| :::.|||..||..|..||:|...
Zfish  1008 GVVKDEPETRVAIKTVNESASLHERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMT 1071

  Fly   495 HGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAA 559
            .|:||.:|...|..      :::...|.||.     |.:|:.|.:||.||.||.:.:.:||||||
Zfish  1072 RGDLKSYLRSLRSV------ENTSSLPLPPL-----KKMIQMAGEIADGMAYLNANKFVHRDLAA 1125

  Fly   560 RNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLW 624
            ||.:|::|:.:||.|||:.|||..||||||...|.||::||:||||::..:.:.|||||:|::||
Zfish  1126 RNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDVWSFGVVLW 1190

  Fly   625 EIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMD 689
            ||.|..:|||.. ||.|::..::|.|..::||..|...::.|||.||.:|...||.|.||:..:.
Zfish  1191 EIATLAEQPYQG-MSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIK 1254

  Fly   690 KLLQTKEDYLDVDIANLDTPPSTSDEEEDETDNL 723
            :.|:..........:..:.||   |.||.:.:|:
Zfish  1255 EDLEAGFKETSFFYSEENKPP---DTEELDMENV 1285

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 22/103 (21%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 3/3 (100%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 0/4 (0%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 20/147 (14%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 2/5 (40%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 1/2 (50%)
Protein Kinases, catalytic domain 404..692 CDD:473864 112/294 (38%)
igf1rbNP_694501.1 Recep_L_domain 47..162 CDD:460032
Furin-like 176..320 CDD:395614
Recep_L_domain 338..449 CDD:460032 10/38 (26%)
FN3 483..595 CDD:238020 26/126 (21%)
FN3 600..>644 CDD:238020 3/43 (7%)
FN3 823..910 CDD:238020 15/91 (16%)
PTKc_InsR_like 980..1255 CDD:173625 112/287 (39%)
Blue background indicates that the domain is not in the aligned region.

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