back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and FRK

DIOPT Version :10

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_002022.1	Gene:	FRK / 2444	HGNCID:	3955	Length:	505	Species:	Homo sapiens

Alignment Length:	506	Identity:	148/506 - (29%)
Similarity:	224/506 - (44%)	Gaps:	110/506 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 HCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWY------TCVESNS 277
            |.:...|.:|::...::|       ||   .:|||:.        ::.|.|:      :..|...
Human    84 HLEKRRDGSSQQLQGYIP-------SN---YVAEDRS--------LQAEPWFFGAIGRSDAEKQL 130

  Fly   278 LGQSNSTAYLRVVR---------SLHVLEAGVAS----GSLHSTSFVYIFVFGGLIFIFMTTLFV 329
            |...|.|... ::|         ||.||:..|..    ..|....|            |:|...:
Human   131 LYSENKTGSF-LIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGF------------FLTRRRI 182

  Fly   330 FYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNE 394
            |..:.            |.|..:||           .|.|....:..|.::||           .
Human   183 FSTLN------------EFVSHYTK-----------TSDGLCVKLGKPCLKIQ-----------V 213

  Fly   395 PAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLV 458
            |||| :..:.....||:.|:.:.|...||.|.||.|.....||.. ||||.:|.|..|.:  ..:
Human   214 PAPF-DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPN--DFL 275

  Fly   459 REMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSP 523
            ||.::||.: ||..:|.|...|:...|:|:|.|...||:|:::|               |.....
Human   276 REAQIMKNL-RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYL---------------QNDTGS 324

  Fly   524 PAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLAR--DIQSTDY 586
            ..|:..:.|:   |.|:|.||.||.||..||||||||||||.:..:.|:|||||||  .:.:.|.
Human   325 KIHLTQQVDM---AAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDI 386

  Fly   587 YRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQ 651
            |......:||:||.|||:::...:..||||||:||||:||:|||:.|| :.|:..::...|....
Human   387 YESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPY-SGMTGAQVIQMLAQNY 450

  Fly   652 RMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVD 702
            |:.:|:.|....|.:|.:||:....:||.|..:...::...:|...|.|.:
Human   451 RLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDAN 501

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.