DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and Styk1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_766479.1	Gene:	Styk1 / 243659	MGIID:	2141396	Length:	429	Species:	Mus musculus

Alignment Length:	409	Identity:	100/409 - (24%)
Similarity:	194/409 - (47%)	Gaps:	45/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 GGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGG---DSSGSMDTMIMPV 378
            ||.:.:....|::|  ||..:     .||.....:.|..|    |...|   :::|..:.:::|:
Mouse    39 GGFLILLAIILWLF--IRGQR-----SQRQSPGPRGTASV----PASRGRSQEAAGHGEKVLLPL 92

  Fly   379 VRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLV-LGATLGEGAFGRVVMAEVNN----- 437
                 :.|:|       ..|.....|..:..::||..|: :...:..|:.|.:..|.:..
Mouse    93 -----KETSV-------EGFLRAATPRLAKLQVPREQLLEVLEQIHSGSCGTLYHATMTTKDHPK 145

  Fly   438 -AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDF 501
             ..|.:|.:::.....::...:..::..:.:|:|.|::.|.|||::..|||:::|....|:|..|
Mouse   146 PKSVVLKALEDPVGLQEVQDFIGRIQFYQYLGKHKNLVQLEGCCTERLPLYMMLEDVVPGDLLSF 210

  Fly   502 LYKNRPFGRD-QDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVS 565
            |:..|   || ...|..       .:.:|||.:.....||...:::|..:...|.|:||||:|:.
Mouse   211 LWTCR---RDVMTMDGL-------LYDLTEKQIYHIGKQILLALEFLQEKHLFHGDVAARNILIQ 265

  Fly   566 DDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYG 630
            .|...|:...|||.::.:........:..:|:||:|||.|..:....:.|:||:||||:|::|.|
Mouse   266 SDLTPKLCHLGLAYEVHAHGAISSARSSTIPLKWLAPERLLLRPASIRGDIWSFGILLYEMVTLG 330

  Fly   631 QQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTK 695
            ..|||.: ....:..||...:.|::|:.||..:|.:|:.||.::.|.||...::::.::...::.
Mouse   331 APPYPEV-PPTSILQYLQRKKIMKRPSSCSHAMYNIMKCCWRWSEDSRPLLGQLLQRLEAASRSA 394

  Fly   696 EDYLDVDIANLDTPPSTSD 714
            :|...:.:..|..|...:|
Mouse   395 DDKAVLQVPELVVPELYAD 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653
		PKc_like	404..692	CDD:304357	79/295 (27%)
		STYKc	416..688	CDD:214568	76/279 (27%)
Styk1	NP_766479.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..83		6/28 (21%)
Styk1	NP_766479.1	PKc_like	123..388	CDD:389743	75/275 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810