DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and Insrr

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_006501514.1 Gene:Insrr / 23920 MGIID:1346037 Length:1313 Species:Mus musculus


Alignment Length:792 Identity:196/792 - (24%)
Similarity:305/792 - (38%) Gaps:200/792 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LLSIWQPAVQVEGR--------RQMANSQEM-IKD--HLGAR---SQNKT------PAITNNANQ 71
            ||..|:|.||..|.        :::|...:: |.|  |.|.|   |.:.|      ||:.....|
Mouse   621 LLVRWKPPVQRNGNITYYLVLWQRLAEDGDLYINDYCHRGLRLPTSSHDTRFDREDPALEAEPEQ 685

  Fly    72 SSTSSADLDDGAA------------DDDDNKADLPVNVSSKPYW------RNPKKMSFLQTRPSG 118
            ..........|.|            ...:|.....:.:...| |      :||::.|....|.:|
Mouse   686 GCCPCQHSPPGQALPALEAQEVTFQKKFENFLHHAITIPKAP-WKVTSINKNPQRDSERHRREAG 749

  Fly   119 SLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCI 183
            .|      .||                       |.|......||.||.:..        .|..:
Mouse   750 LL------RLG-----------------------KNNSDFEIQEDKVPRERA--------ILSGL 777

  Fly   184 RHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAW-----IFVPCHGMTNC 243
            ||.|:..:.....:......|....|.|...|  |..:....:..|.||     ..|..|.:...
Mouse   778 RHFTEYRIDIHACNHAAHTVGCSAATFVFART--MPHREADGIPGKVAWKAAGKSSVTLHWLEPP 840

  Fly   244 SNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVR----SLHVLEAGVASGS 304
            ..|..|:   |.::.:  .|:.:|....||           :.||..:    .|.:|..|..|..
Mouse   841 DPNGLIL---KYEIKY--RRLGEEATVLCV-----------SRLRYAKVGGVHLALLPPGNYSAK 889

  Fly   305 LHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSG 369
            :.:||..     |.                               ..||..|..:..:...:.:|
Mouse   890 VRATSLA-----GN-------------------------------GSWTDGVTFYITDLEEEDTG 918

  Fly   370 SMDTMI-------MPVVRI-------QKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGA 420
            .|...:       |.:|.:       .::|.:.|.....|..|:.....:...||:||..:.:..
Mouse   919 GMRIFLTVTPVGFMLLVTLAALGFFYSRKRNSTLYTSVNPEYFSASHMYVPDEWEVPREQIAIIR 983

  Fly   421 TLGEGAFGRV-------VMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRH-------- 470
            .||:|:||.|       :.|...:..||:|.|.|..:..:....::|..|||....|        
Mouse   984 ELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVRQEGLP 1048

  Fly   471 ----INIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEK 531
                .:.:.|||..||..|..||:|....|:||..|...||   :.:.:...|.|:       ..
Mouse  1049 QRSLSSQVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRP---EAENNPGLPQPA-------LS 1103

  Fly   532 DLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLP 596
            |:|:.|.:||.||.|||:::.:||||||||.:||.|:.:||.|||:.||:..||||||...|.||
Mouse  1104 DMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLP 1168

  Fly   597 IKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSM 661
            ::|||||||::..:.:.|||||:|::||||:|..:|||.. :|.|::..::|.|..:|:...|.:
Mouse  1169 VRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQG-LSNEQVLKFVMDGGVLEELENCPI 1232

  Fly   662 NIYILMRQCWHFNADDRPPFTEIVE----------------YMDKLLQTKEDYLDVDIANLDTPP 710
            .:..|||.||..:...||.|..|::                |..:..:.:...|..: |..|:||
Mouse  1233 QLQELMRLCWQHSPRLRPTFVHILDRIQDELRPSFRLCSFYYSPECQRGQASLLPTE-AEPDSPP 1296

  Fly   711 STSDEEEDETDN 722
            :.:...:....|
Mouse  1297 TLNGASDYSAPN 1308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 20/95 (21%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 0/3 (0%)
Ig strand F 171..176 CDD:409353 0/4 (0%)
Ig strand G 184..187 CDD:409353 2/2 (100%)
Ig 200..289 CDD:472250 18/93 (19%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 3/8 (38%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 1/4 (25%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 112/322 (35%)
InsrrXP_006501514.1 Recep_L_domain 47..158 CDD:460032
Furin-like 173..326 CDD:395614
Recep_L_domain 346..461 CDD:460032
FN3 494..600 CDD:238020
FN3 605..>649 CDD:238020 8/27 (30%)
FN3 819..908 CDD:238020 24/140 (17%)
PTKc_InsR_like 972..1261 CDD:173625 111/299 (37%)
Blue background indicates that the domain is not in the aligned region.

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