Protein Alignment htl and ALK

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_004295.2
• Gene: ALK / 238
• HGNCID: 427
• Length: 1620
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 150/538 - (27%)
• Similarity: 234/538 - (43%)
• Gaps: 128/538 - (23%)

  Fly   204 GPLNLTLVVNSTGSMHCKY---LSDLTSKKAWIFVPC-HGMTNCSNNRSIIAEDKDQLDFVNVRM 264
            |.:|:...:|.:   ||:.   ..|..|.|...|  | ||        :::|||
Human   977 GEVNIKHYLNCS---HCEVDECHMDPESHKVICF--CDHG--------TVLAED----------- 1017

  Fly   265 EQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFV 329
                ..:|:.|     .....:|.:...|.|:.:.:.:        ..:..|.|::.::
Human  1018 ----GVSCIVS-----PTPEPHLPLSLILSVVTSALVA--------ALVLAFSGIMIVY------ 1059

  Fly   330 FYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNE 394
                 :.||:::...::|                          :..|..::.|.||:.:.....
Human  1060 -----RRKHQELQAMQME--------------------------LQSPEYKLSKLRTSTIMTDYN 1093

  Fly   395 PAPFNEYEF-----PLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNN-------AIVAVKMVKE 447
            |    .|.|     .:....|:||.::.|...||.||||.|...:|:.       ..||||.:.|
Human  1094 P----NYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPE 1154

  Fly   448 GHTD-DDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRD 511
            ..:: |::..|:..:.:.|.  .|.||:..:|...|:.|.::::|....|:||.||.:.|
Human  1155 VCSEQDELDFLMEALIISKF--NHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETR----- 1212

  Fly   512 QDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVS---DDYVLKIA 573
                   |.||.|:. :...||:..|..||.|..||.....||||:||||.|::   ...|.||.
Human  1213 -------PRPSQPSS-LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIG 1269

  Fly   574 DFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIM 638
            |||:||||....||||.....||:|||.||:..|..:.||:|.||:|:|||||.:.|..|||: .
Human  1270 DFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS-K 1333

  Fly   639 SAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKEDYLDVDI 703
            |.:|:..::.||.||:.|..|...:|.:|.|||....:|||.|..|:|.::...|      |.|:
Human  1334 SNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQ------DPDV 1392

  Fly   704 ANLDTP----PSTSDEEE 717
            .|...|    |...:||:
Human  1393 INTALPIEYGPLVEEEEK 1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250	18/88 (20%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	110/298 (37%)
ALK	NP_004295.2	Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012	48..70
		MAM	266..424	CDD:99706
		LDLa	441..467	CDD:197566
		MAM	480..635	CDD:459878
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..674
		EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673	987..1025		14/70 (20%)
		FXa_inhibition	987..1021	CDD:464251	12/61 (20%)
		PTKc_ALK_LTK	1109..1385	CDD:270632	110/291 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1408..1463		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1514..1540