Protein Alignment htl and Map3k21

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_663583.2
• Gene: Map3k21 / 234878
• MGIID: 2385307
• Length: 1002
• Species: Mus musculus
• Alignment Length: 358
• Identity: 110/358 - (30%)
• Similarity: 165/358 - (46%)
• Gaps: 58/358 - (16%)

  Fly   395 PAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIA---S 456
            |.|.:    |:..::|    .|.|...:|.|.||:|..|......||||..:.....|..|   |
Mouse    97 PRPCS----PVHVDFE----RLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAES 153

  Fly   457 LVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQP-P 520
            :.||..:..:: ||.|||.|.|.|.:...|.:::|:|..|.|      ||...    ..:|.| .
Mouse   154 VRREARLFAML-RHPNIIQLRGVCLRQPHLCLVLEFARGGAL------NRALA----AAASDPRA 207

  Fly   521 PSP-PAHVITEKDLIKFAHQIARGMDYLASRRCI---HRDLAARNVLV-----SDDY---VLKIA 573
            |.| .|..|..:.|:.:|.||||||.||.....:   ||||.:.|:|:     .||.   .|||.
Mouse   208 PGPRRARRIPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKIT 272

  Fly   574 DFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIM 638
            ||||||:...|.  |.:..|  ...|||||.::...:...||:||||:||||::| |:.||..|.
Mouse   273 DFGLAREWHRTT--RMSAAG--TYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLT-GEVPYRGID 332

  Fly   639 SAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQT--------- 694
            .....|...::...:..|:.|......||::||..:...||.|..|::.:..:.:.
Mouse   333 GLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQLTAIEEAVLTNMPQES 397

  Fly   695 ----KEDYLDVDIANLDTPPSTSDEE----EDE 719
                :||: .::|..:.:...|.::|    |:|
Mouse   398 FHSMQEDW-KLEIQQMFSELRTKEKELRSREEE 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	101/303 (33%)
Map3k21	NP_663583.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		SH3	28..82	CDD:473055
		Protein Kinases, catalytic domain	115..385	CDD:473864	97/285 (34%)
		Leucine-zipper 1	409..430		5/21 (24%)
		Leucine-zipper 2	444..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	508..531
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	574..604
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..689
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..778
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	797..823
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	878..899