DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and FLT3

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_004110.2	Gene:	FLT3 / 2322	HGNCID:	3765	Length:	993	Species:	Homo sapiens

Alignment Length:	702	Identity:	197/702 - (28%)
Similarity:	281/702 - (40%)	Gaps:	245/702 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 ADDDDNKAD--LPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYR------N 140
            |::||.:..  ..:|:..||           |.....|....:|.:.|.|.|:.||.:      |
Human   420 AENDDAQFTKMFTLNIRRKP-----------QVLAEASASQASCFSDGYPLPSWTWKKCSDKSPN 473

  Fly   141 GTVDWTRGYGSLKRNR-----W----TLTMEDLVPGDCGNYTCKVC--NSLGCIRHDTQVIVSDR 194
            .|.:.|.|..:.|.||     |    ||.|.:.:.|    :..|.|  ||||
Human   474 CTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKG----FLVKCCAYNSLG------------- 521

  Fly   195 VNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDF 259
                                                          |:|   .:|:........|
Human   522 ----------------------------------------------TSC---ETILLNSPGPFPF 537

  Fly   260 VNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFM 324
            :                   |.|.:.|..:         ||.                 |:||.:
Human   538 I-------------------QDNISFYATI---------GVC-----------------LLFIVV 557

  Fly   325 TTLFVFYAIRK-MKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTV 388
            .||.:.:..:| .::|..| |.::.                   :||.|.....|
Human   558 LTLLICHKYKKQFRYESQL-QMVQV-------------------TGSSDNEYFYV---------- 592

  Fly   389 LQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN-------NAIVAVKMVK 446
                    .|.|||:  |..||.||.:|..|..||.||||:|:.|...       :..|||||:|
Human   593 --------DFREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK 647

  Fly   447 EGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFL-YKNRPFGR 510
            |.....:..:|:.|:::|..:|.|.||:||||.|:.:||:|:|.||..:|:|.::| .|...|.|
Human   648 EKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHR 712

  Fly   511 D----------------QDRDSSQPPPS------PPA---------------------------- 525
            .                |...:|..|.|      |.:
Human   713 TWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEE 777

  Fly   526 ---HVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY 587
               :|:|.:||:.||:|:|:||::|..:.|:|||||||||||:...|:||.||||||||.|...|
Human   778 EDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842

  Fly   588 RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQR 652
            ....|.|||:||||||||.|..|..||||||||||||||.:.|..|||.|......|..:.:|.:
Human   843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFK 907

  Fly   653 MEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKED--YLDVD 702
            |::|...:..|||:|:.||.|::..||.|..:..::...|...|:  |.:||
Human   908 MDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVD 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	26/95 (27%)
		IG_like	113..191	CDD:214653	26/94 (28%)
		IG_like	205..289	CDD:214653	7/83 (8%)
		PKc_like	404..692	CDD:304357	134/348 (39%)
		STYKc	416..688	CDD:214568	129/332 (39%)
FLT3	NP_004110.2	ig	256..345	CDD:278476
		PKc_like	572..947	CDD:304357	145/414 (35%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand	591..597		2/23 (9%)
		Pkinase_Tyr	610..943	CDD:285015	129/332 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810