DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and FLT1

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_002010.2 Gene:FLT1 / 2321 HGNCID:3763 Length:1338 Species:Homo sapiens


Alignment Length:773 Identity:222/773 - (28%)
Similarity:331/773 - (42%) Gaps:202/773 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 SIWQPAVQVEGRRQMANSQEMIKDHLG----ARSQNKTPAITNNANQSSTSSADLDDGAADDDDN 89
            ||.|....:||:.:||::..:....:.    ..:.||...:..|.:...|   |:.:|       
Human   504 SITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVGTVGRNISFYIT---DVPNG------- 558

  Fly    90 KADLPVNVSSKPYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKR 154
               ..||:...|              ..|..|.|:|........::||....||:....:.|:.:
Human   559 ---FHVNLEKMP--------------TEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISK 606

  Fly   155 NRWTLTMEDLVP----------GDCGNYTCKVCNSLGCIRHDTQVI----VSDRVNHKPILMTGP 205
            .:..:|.|..:.          .|.|.|.|:..|    :....:::    ::.|....|.|:...
Human   607 QKMAITKEHSITLNLTIMNVSLQDSGTYACRARN----VYTGEEILQKKEITIRDQEAPYLLRNL 667

  Fly   206 LNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRS-------IIAEDKDQLDFVNVR 263
            .:.|:.::|:.::.|....          ||...:|...||..       |:......|....|.
Human   668 SDHTVAISSSTTLDCHANG----------VPEPQITWFKNNHKIQQEPGIILGPGSSTLFIERVT 722

  Fly   264 MEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFV----FGGLIFIFM 324
            .|.||.|.|..:|..|...|:|||.|            .|:...::...|.:    ....:|..:
Human   723 EEDEGVYHCKATNQKGSVESSAYLTV------------QGTSDKSNLELITLTCTCVAATLFWLL 775

  Fly   325 TTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVL 389
            .|||    |||||.                            ||..:.|..:.::.         
Human   776 LTLF----IRKMKR----------------------------SSSEIKTDYLSIIM--------- 799

  Fly   390 QNGNEPAPFNEY--EFPLD-SNWELPRSHLVLGATLGEGAFGRVVMAEV-------NNAIVAVKM 444
              ..:..|.:|.  ..|.| |.||..|..|.||.:||.||||:||.|..       ....|||||
Human   800 --DPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKM 862

  Fly   445 VKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCS-QNGPLYVIVEYAPHGNLKDFLYKNRPF 508
            :|||.|..:..:|:.|::::..||.|:|::||||.|: |.|||.|||||..:|||.::|...|..
Human   863 LKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL 927

  Fly   509 ------------------------GR-----------------------------DQDRDSSQPP 520
                                    |:                             ::|.|.....
Human   928 FFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKE 992

  Fly   521 PSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDI-QST 584
            |      ||.:|||.::.|:||||::|:||:||||||||||:|:|::.|:||.|||||||| ::.
Human   993 P------ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNP 1051

  Fly   585 DYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMS 649
            ||.||. :.|||:|||||||:.:|.|.:||||||||:|||||.:.|..|||.:...|:..:.|..
Human  1052 DYVRKG-DTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLRE 1115

  Fly   650 GQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTK-----EDYLDVD 702
            |.||..|...:..||.:|..|||.:..:||.|.|:||.:..|||..     :||:.::
Human  1116 GMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPIN 1173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 16/92 (17%)
IG_like 113..191 CDD:214653 16/91 (18%)
IG_like 205..289 CDD:214653 22/90 (24%)
PKc_like 404..692 CDD:304357 143/350 (41%)
STYKc 416..688 CDD:214568 137/333 (41%)
FLT1NP_002010.2 IG_like 143..219 CDD:214653
IG_like 237..328 CDD:214653
Ig1_VEGFR_like 245..327 CDD:143219
Ig2_VEGFR-1 353..424 CDD:143326
IG 568..640 CDD:214652 15/71 (21%)
IGc2 569..640 CDD:197706 15/70 (21%)
I-set 661..748 CDD:254352 24/96 (25%)
IGc2 676..738 CDD:197706 16/71 (23%)
PTKc_VEGFR1 819..1157 CDD:271109 140/344 (41%)
Pkinase_Tyr 827..1154 CDD:285015 137/333 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..982 1/41 (2%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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