Protein Alignment htl and LMTK2

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_055731.2
• Gene: LMTK2 / 22853
• HGNCID: 17880
• Length: 1503
• Species: Homo sapiens
• Alignment Length: 360
• Identity: 84/360 - (23%)
• Similarity: 158/360 - (43%)
• Gaps: 59/360 - (16%)

  Fly   386 TTVLQNGNEPAPFNEYEFPLDS-NWELPRSHLVLGATLGEGAFGRVVMAEV----NNAIVAVKMV 445
            |..:.|.:.||| ::::..::. ..::.|..|.....:|.|.||:|::.|:    :.|.|.||.:
Human   107 TLSVPNISLPAP-SQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKEL 170

  Fly   446 KEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGR 510
            |......:..:.::..|...|: :|.||:..:|.|.:..|..::.|:...|:||.:|...    :
Human   171 KASANPKEQDTFLKNGEPYYIL-QHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSE----Q 230

  Fly   511 DQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADF 575
            :..|..||           ...|.:.|.::|.|:..:.....:|.|||.||..::.|..:|:.|:
Human   231 EHMRGDSQ-----------TMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDY 284

  Fly   576 GLARDIQSTDYYRKNTNGRLPIKWMAPE---SLQEKFYDSK----SDVWSYGILLWEIMTYGQQP 633
            |:.......||...:.....|::|.|||   |.|::...:.    |::||.|:.|||:.....||
Human   285 GIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQP 349

  Fly   634 YPTIMSAEELYTYL------MSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL- 691
            |..:.:.:.|...:      :...::|:|  .|...|.:::.|| .:.:.||...::...:..|
Human   350 YSNLSNLDVLNQVIRERDTKLPKPQLEQP--YSDRWYEVLQFCW-LSPEKRPAAEDVHRLLTYLR 411

  Fly   692 LQTKEDYLDVDIANLDTPPSTSDEEEDETDNLQKW 726
            ||::.|                    .|.|..|:|
Human   412 LQSQRD--------------------SEVDFEQQW 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	72/306 (24%)
LMTK2	NP_055731.2	PTKc_Aatyk2	139..409	CDD:270669	69/288 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	597..622
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	804..840
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	875..898
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	970..999
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1013..1202
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1276..1317
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1372..1469