DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and FGFR4

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001341913.1	Gene:	FGFR4 / 2264	HGNCID:	3691	Length:	802	Species:	Homo sapiens

Alignment Length:	738	Identity:	288/738 - (39%)
Similarity:	383/738 - (51%)	Gaps:	98/738 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PAVQVEGRRQMANSQEMIKDHLG-----ARS-----QNKTPAITNNANQSSTSSADLDDGAAD-D 86
            ||.:|.|.|........:.:..|     ||.     ||.| .||.:   |.|||.|.:|..:. |
Human    75 PAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLT-LITGD---SLTSSNDDEDPKSHRD 135

  Fly    87 DDNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTV---DWTR 147
            ..|:...|   ...|||.:|::| ..|...|:|:.:...|.|.|||.|.|.|.::|..   :...
Human   136 PSNRHSYP---QQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRI 197

  Fly   148 GYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLV 211
            |...|:...|:|.||.:||.|.|.|||.|.|::|.||::..:.|.:|..|:|||..| |.|.|.|
Human   198 GGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAV 262

  Fly   212 VNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSN-------------NRSIIAEDKDQLDFVNVR 263
            |.|...:.||..||......|:   .|.:.|.|:             ...|.:.:.:.|...||.
Human   263 VGSDVELLCKVYSDAQPHIQWL---KHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVS 324

  Fly   264 MEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLF 328
            .|..|.|||:..||:|.|..:|:|.|:..........|..:.::.  :.::..|.|....:..|.
Human   325 AEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTD--IILYASGSLALAVLLLLA 387

  Fly   329 VFY--------------AIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVV 379
            ..|              .::|:....:.:|              |..|.|  |||...:.::..|
Human   388 GLYRGQALHGRHPRPPATVQKLSRFPLARQ--------------FSLESG--SSGKSSSSLVRGV 436

  Fly   380 RIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV--------- 435
            |:......:|      |.....:.|||..||.||..||||..||||.||:||.||.
Human   437 RLSSSGPALL------AGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPD 495

  Fly   436 NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKD 500
            ..:.|||||:|:..:|.|:|.||.||||||:||||.|||||||.|:|.||||||||.|..|||::
Human   496 QASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLRE 560

  Fly   501 FLYKNRPFGRDQDRD---SSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNV 562
            ||...||.|.|...|   ||:.|.|.|.       |:..|:|:||||.||.||:|||||||||||
Human   561 FLRARRPPGPDLSPDGPRSSEGPLSFPV-------LVSCAYQVARGMQYLESRKCIHRDLAARNV 618

  Fly   563 LVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIM 627
            ||::|.|:|||||||||.:...|||:|.:|||||:||||||:|.::.|..:|||||:|||||||.
Human   619 LVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIF 683

  Fly   628 TYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK-L 691
            |.|..|||.| ..|||::.|..|.||::|..|...:|.|||:|||.....||.|.::||.:|| |
Human   684 TLGGSPYPGI-PVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVL 747

  Fly   692 LQTKEDYLDVDIANLDTPPSTSD 714
            |...|:|||:.:......||..|
Human   748 LAVSEEYLDLRLTFGPYSPSGGD 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	30/81 (37%)
		IG_like	113..191	CDD:214653	29/80 (36%)
		IG_like	205..289	CDD:214653	29/96 (30%)
		PKc_like	404..692	CDD:304357	168/300 (56%)
		STYKc	416..688	CDD:214568	159/283 (56%)
FGFR4	NP_001341913.1	IGc2	50..107	CDD:197706	8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..148		9/34 (26%)
		Ig	157..241	CDD:325142	30/83 (36%)
		Ig3_FGFR-2	264..351	CDD:143266	24/89 (27%)
		PKc_like	454..767	CDD:328722	174/320 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1191
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1485
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8598
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770