Protein Alignment htl and Zap70

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001276695.1
• Gene: Zap70 / 22637
• MGIID: 99613
• Length: 642
• Species: Mus musculus
• Alignment Length: 672
• Identity: 166/672 - (24%)
• Similarity: 276/672 - (41%)
• Gaps: 160/672 - (23%)

  Fly   115 RPSGSLL-----TLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTC 174
            :|..|||     .|...|:.:|..::.::          |||:.|......::.....| |.:..
Mouse     7 KPGRSLLPSVVCLLQGPAMPDPAAHLPFF----------YGSISRAEAEEHLKLAGMAD-GLFLL 60

  Fly   175 KVC-NSLG----CIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCK-------YLSDLT 227
            :.| .|||    .:.||.      |.:|.||  ...||.|..: :.|..||.       |..|..
Mouse    61 RQCLRSLGGYVLSLVHDV------RFHHFPI--ERQLNGTYAI-AGGKAHCGPAELCQFYSQDPD 116

  Fly   228 SKKAWIFVPCH---------GMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQS-- 281
            .....:..||:         |:.:|..:..:       .|:|....:.||  ..:|...:.|:
Mouse   117 GLPCNLRKPCNRPPGLEPQPGVFDCLRDAMV-------RDYVRQTWKLEG--DALEQAIISQAPQ 172

  Fly   282 -----NSTAYLRVVRSLHVLEAGVASGSLHS----------------TSFVYIFVFGGLIFIFM- 324
                 .:||:.|:......|....|...|:|                .::....|:|..::.::
Mouse   173 VEKLIATTAHERMPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKEQGTYALSLVYGKTVYHYLI 237

  Fly   325 ----------------TTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDT 373
                            .||:......|:|.:.::.:..|.....:....:..|......|    |
Mouse   238 SQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAAVAAPTLPAHPS----T 298

  Fly   374 MIMPVVRIQKQRTTVLQNGNEPAPF-------NEYEFPLDSN-WELPRSH--------------- 415
            ...|    |::..|:..:|..|.|.       .....|:|:: :|.|.|.
Mouse   299 FTQP----QRRVDTLNSDGYTPEPARLASSTDKPRPMPMDTSVYESPYSDPEELKDKKLFLKREN 359

  Fly   416 -LVLGATLGEGAFG-------RVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHIN 472
             ||....||.|.||       |:...:::   ||:|::|:|....|...::||.::|..:....
Mouse   360 LLVADIELGCGNFGSVRQGVYRMRKKQID---VAIKVLKQGTEKADKDEMMREAQIMHQLDNPY- 420

  Fly   473 IINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFA 537
            |:.|:|.| |...|.:::|.|..|.|..||     .|:.::              |...::.:..
Mouse   421 IVRLIGVC-QAEALMLVMEMAGGGPLHKFL-----LGKKEE--------------IPVSNVAELL 465

  Fly   538 HQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTD-YYRKNTNGRLPIKWMA 601
            ||:|.||.||..:..:||||||||||:.:.:..||:||||::.:.:.| ||...:.|:.|:||.|
Mouse   466 HQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 530

  Fly   602 PESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYIL 666
            ||.:..:.:.|:|||||||:.:||..:|||:||.. |...|:..::..|:|||.|.:|...:|.|
Mouse   531 PECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKK-MKGPEVLDFIKQGKRMECPPECPPEMYAL 594

  Fly   667 MRQCWHFNADDRPPFTEIVEYM 688
            |..||.:..:|||.|..:.:.|
Mouse   595 MSDCWIYKWEDRPDFLTVEQRM 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	19/85 (22%)
		Ig strand B	121..125	CDD:409353	2/8 (25%)
		Ig strand C	134..138	CDD:409353	0/3 (0%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	0/4 (0%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	21/111 (19%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	0/4 (0%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	102/310 (33%)
Zap70	NP_001276695.1	SH2_N-SH2_Zap70_Syk_like	32..135	CDD:198191	26/122 (21%)
		SH2	176..280	CDD:472789	14/103 (14%)
		PTKc_Zap-70	356..624	CDD:270686	97/286 (34%)