DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and FGFR2

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_006717771.1	Gene:	FGFR2 / 2263	HGNCID:	3689	Length:	839	Species:	Homo sapiens

Alignment Length:	832	Identity:	300/832 - (36%)
Similarity:	418/832 - (50%)	Gaps:	147/832 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAAWSWRASH----STITMTSGS-----LVVLFLLLS------------------------IWQ 32
            |....:||...    .|:||.|..     :||....||                        |.|
Human     1 MGLTSTWRYGRGPGIGTVTMVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQ 65

  Fly    33 PAVQVEGRRQMANSQEMIKD-----------HLGARSQ--------------------------- 59
            |.|.|....:....:.::||           |||..::
Human    66 PEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASR 130

  Fly    60 -----------NKTPAITNNANQSSTSSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKM-SFL 112
                       |.|.||::..::..|..|  :|..:::.:||        ..|||.|.:|| ..|
Human   131 TVDSETWYFMVNVTDAISSGDDEDDTDGA--EDFVSENSNNK--------RAPYWTNTEKMEKRL 185

  Fly   113 QTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTR-----GYGSLKRNRWTLTMEDLVPGDCGNY 172
            ...|:.:.:...|.|.|||.|.:.|.:||. ::.:     || .::...|:|.||.:||.|.|||
Human   186 HAVPAANTVKFRCPAGGNPMPTMRWLKNGK-EFKQEHRIGGY-KVRNQHWSLIMESVVPSDKGNY 248

  Fly   173 TCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVP 236
            ||.|.|..|.|.|...:.|.:|..|:|||..| |.|.:.||.......||..||......||
Human   249 TCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWI--- 310

  Fly   237 CHGMTNCS-------------NNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLR 288
            .|...|.|             .:..|.:.:.:.|...||.....|.|.|..||.:||:|.:|:|.
Human   311 KHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLT 375

  Fly   289 VVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIR-KMKH--EKVLKQRIETVH 350
            |:.....  .|.......|..::.|.::  .|.:|:....|...|. :||:  :|........||
Human   376 VLPKQQA--PGREKEITASPDYLEIAIY--CIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVH 436

  Fly   351 QWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPR 413
            :.||::.: :.:...:||.||::. .|:|||   .|.:....:.|  |..:|||.|.|..||.||
Human   437 KLTKRIPL-RRQVSAESSSSMNSN-TPLVRI---TTRLSSTADTPMLAGVSEYELPEDPKWEFPR 496

  Fly   414 SHLVLGATLGEGAFGRVVMAEV--------NNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGR 469
            ..|.||..||||.||:|||||.        ..|: |||||:|:..|:.|::.||.|||:||:||:
Human   497 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGK 561

  Fly   470 HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLI 534
            |.|||||||.|:|:||||||||||..|||:::|...||.|.:...|.::.|...    :|.|||:
Human   562 HKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ----MTFKDLV 622

  Fly   535 KFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKW 599
            ...:|:||||:||||::|||||||||||||:::.|:|||||||||||.:.|||:|.||||||:||
Human   623 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKW 687

  Fly   600 MAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIY 664
            ||||:|.::.|..:|||||:|:|:|||.|.|..|||.| ..|||:..|..|.||:|||.|:..:|
Human   688 MAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTNELY 751

  Fly   665 ILMRQCWHFNADDRPPFTEIVEYMDKL--LQTKEDYLDVDIANLDTPPSTSD 714
            ::||.|||.....||.|.::||.:|::  |.|.|:|||:........||..|
Human   752 MMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPD 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	30/83 (36%)
		IG_like	113..191	CDD:214653	29/82 (35%)
		IG_like	205..289	CDD:214653	27/96 (28%)
		PKc_like	404..692	CDD:304357	162/298 (54%)
		STYKc	416..688	CDD:214568	155/280 (55%)
FGFR2	XP_006717771.1	Ig1_FGFR	66..143	CDD:143174	8/76 (11%)
		IG_like	66..143	CDD:214653	8/76 (11%)
		Ig2_FGFR	183..267	CDD:143265	30/85 (35%)
		IG_like	282..376	CDD:214653	27/96 (28%)
		Ig3_FGFR	290..377	CDD:143175	23/89 (26%)
		PTKc_FGFR2	474..786	CDD:270679	169/316 (53%)
		Pkinase_Tyr	499..775	CDD:285015	155/280 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1191
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1485
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8598
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.740