DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and FGFR3

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:XP_006713931.1 Gene:FGFR3 / 2261 HGNCID:3690 Length:811 Species:Homo sapiens


Alignment Length:693 Identity:282/693 - (40%)
Similarity:391/693 - (56%) Gaps:81/693 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 SSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHALGNPEPNITWY 138
            ||.|.:||..:.:|...|     :..|||..|::| ..|...|:.:.:...|.|.|||.|:|:|.
Human   130 SSGDDEDGEDEAEDTGVD-----TGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWL 189

  Fly   139 RNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPI 200
            :||..   :...|...|:..:|:|.||.:||.|.|||||.|.|..|.||....:.|.:|..|:||
Human   190 KNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPI 254

  Fly   201 LMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSN-----------NRSIIAED 253
            |..| |.|.|.|:.|....|||..||......|:   .|...|.|.           .:|.|:|.
Human   255 LQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWL---KHVEVNGSKVGPDGTPYVTVLKSWISES 316

  Fly   254 KD---QLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLH--------VLEAGVASGSLHS 307
            .:   :|...||.....|.|.|..:|.:|.:....:|    |:|        ::||..| ||:::
Human   317 VEADVRLRLANVSERDGGEYLCRATNFIGVAEKAFWL----SVHGPRAAEEELVEADEA-GSVYA 376

  Fly   308 TSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRI--ETVHQWTKKVIIFKPEGGGDSSGS 370
            .    |..:|...|:|   :.|..|:...:.....|:.:  .|||:.::..:..:.....:|:.|
Human   377 G----ILSYGVGFFLF---ILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVTVSLESNAS 434

  Fly   371 MDTMIMPVVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMA 433
            |.:. .|:|||.:     |.:|..|  |..:|.|.|.|..|||.|:.|.||..||||.||:||||
Human   435 MSSN-TPLVRIAR-----LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMA 493

  Fly   434 E---------VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVI 489
            |         .....|||||:|:..||.|::.||.|||:||:||:|.|||||||.|:|.|||||:
Human   494 EAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVL 558

  Fly   490 VEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIH 554
            ||||..|||::||...||.|.|...|:.:||...    :|.|||:..|:|:||||:||||::|||
Human   559 VEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQ----LTFKDLVSCAYQVARGMEYLASQKCIH 619

  Fly   555 RDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSY 619
            ||||||||||::|.|:||||||||||:.:.|||:|.||||||:||||||:|.::.|..:|||||:
Human   620 RDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSF 684

  Fly   620 GILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEI 684
            |:|||||.|.|..|||.| ..|||:..|..|.||:|||.|:.::|::||:|||.....||.|.::
Human   685 GVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 748

  Fly   685 VEYMDKLL---QTKEDYLDVDI-------ANLDTPPSTSDEEE 717
            ||.:|::|   .|.::|||:..       ...|||.|:|..::
Human   749 VEDLDRVLTVTSTDQEYLDLSAPFEQYSPGGQDTPSSSSSGDD 791

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 36/93 (39%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 1/3 (33%)
Ig strand E 157..161 CDD:409353 2/3 (67%)
Ig strand F 171..176 CDD:409353 4/4 (100%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 29/103 (28%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/6 (17%)
Ig strand F 269..274 CDD:409353 2/4 (50%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 166/296 (56%)
FGFR3XP_006713931.1 Ig 37..109 CDD:472250
Ig strand B 57..61 CDD:409362
Ig strand C 69..75 CDD:409362
Ig strand E 92..96 CDD:409362
IgI_2_FGFR 151..245 CDD:409443 36/93 (39%)
Ig strand A 151..154 CDD:409443 2/2 (100%)
Ig strand A' 162..167 CDD:409443 1/4 (25%)
Ig strand B 171..179 CDD:409443 1/7 (14%)
Ig strand C 185..190 CDD:409443 2/4 (50%)
Ig strand C' 193..195 CDD:409443 0/1 (0%)
Ig strand D 204..207 CDD:409443 0/2 (0%)
Ig strand E 211..216 CDD:409443 2/4 (50%)
Ig strand F 225..232 CDD:409443 5/6 (83%)
Ig strand G 235..245 CDD:409443 3/9 (33%)
IgI_3_FGFR 253..354 CDD:409363 30/107 (28%)
Ig strand A 253..256 CDD:409363 2/2 (100%)
Ig strand A' 260..264 CDD:409363 2/3 (67%)
Ig strand B 272..279 CDD:409363 3/6 (50%)
Ig strand C 283..290 CDD:409363 1/9 (11%)
Ig strand D 305..310 CDD:409363 0/4 (0%)
Ig strand E 321..326 CDD:409363 1/4 (25%)
Ig strand F 334..342 CDD:409363 3/7 (43%)
Ig strand G 345..353 CDD:409363 1/7 (14%)
Protein Kinases, catalytic domain 463..797 CDD:473864 176/334 (53%)
Blue background indicates that the domain is not in the aligned region.

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