DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and FGFR1

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001167538.1 Gene:FGFR1 / 2260 HGNCID:3688 Length:853 Species:Homo sapiens


Alignment Length:816 Identity:298/816 - (36%)
Similarity:423/816 - (51%) Gaps:128/816 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 WSWR-----ASHSTITM-TSGSLVVLFLLLSIWQPAVQVEG--------------RRQMANSQEM 49
            |||:     |...|.|: |:.....|......|...|:||.              .|....|...
Human    35 WSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINW 99

  Fly    50 IKDHLGARSQNKT-------------PA-------ITNNANQSSTS-----------SADLDDGA 83
            ::|.:.....|:|             ||       :|::.:.|.|:           |::.||  
Human   100 LRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDD-- 162

  Fly    84 ADDDDNKADLPVNVSSK-----PYWRNPKKM-SFLQTRPSGSLLTLNCHALGNPEPNITWYRNG- 141
             ||||:.::.....::|     |||.:|:|| ..|...|:...:...|.:.|.|.|.:.|.:|| 
Human   163 -DDDDSSSEEKETDNTKPNPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGK 226

  Fly   142 --TVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG 204
              ..|...|...::...|::.|:.:||.|.|||||.|.|..|.|.|..|:.|.:|..|:|||..|
Human   227 EFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAG 291

  Fly   205 -PLNLTLVVNSTGSMHCKYLSDLTSKKAWI-FVPCHGMTNCSNN---------RSIIAEDKDQ-- 256
             |.|.|:.:.|.....||..||......|: .:..:|.....:|         ..:...||:.  
Human   292 LPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEV 356

  Fly   257 LDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIF 321
            |...||..|..|.|||:..||:|.|:.:|:|.|:.:|....| |.:..|:..  :.|:..|..:.
Human   357 LHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPA-VMTSPLYLE--IIIYCTGAFLI 418

  Fly   322 IFMTTLFVFYAIRKMK--------HEKVLKQRIETVHQWTKKVIIFKP-EGGGDSSGSMDTMIMP 377
            ..|....:.|   |||        |.::      .||:..|.:.:.:. ....|||.||::.::.
Human   419 SCMVGSVIVY---KMKSGTKKSDFHSQM------AVHKLAKSIPLRRQVTVSADSSASMNSGVLL 474

  Fly   378 VVRIQKQRTTVLQNGNEP--APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV----- 435
            |      |.:.|.:...|  |..:|||.|.|..|||||..||||..||||.||:||:||.     
Human   475 V------RPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDK 533

  Fly   436 --NNAI--VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHG 496
              .|.:  |||||:|...|:.|::.|:.|||:||:||:|.|||||||.|:|:||||||||||..|
Human   534 DKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKG 598

  Fly   497 NLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARN 561
            ||:::|...||.|.:.    ...|...|...::.|||:..|:|:||||:||||::||||||||||
Human   599 NLREYLQARRPPGLEY----CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 659

  Fly   562 VLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEI 626
            |||::|.|:|||||||||||...|||:|.||||||:||||||:|.::.|..:|||||:|:|||||
Human   660 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEI 724

  Fly   627 MTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691
            .|.|..|||.: ..|||:..|..|.||:||:.|:..:|::||.|||.....||.|.::||.:|::
Human   725 FTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 788

  Fly   692 --LQTKEDYLDVDI-------ANLDTPPSTSDEEED 718
              |.:.::|||:.:       :..||..||....||
Human   789 VALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGED 824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 33/93 (35%)
Ig strand B 121..125 CDD:409353 0/3 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 1/3 (33%)
Ig strand F 171..176 CDD:409353 4/4 (100%)
Ig strand G 184..187 CDD:409353 1/2 (50%)
Ig 200..289 CDD:472250 30/101 (30%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/5 (20%)
Ig strand F 269..274 CDD:409353 3/4 (75%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 162/298 (54%)
FGFR1NP_001167538.1 IgI_1_FGFR 58..151 CDD:409362 15/92 (16%)
Ig strand A 58..61 CDD:409362 0/2 (0%)
Ig strand A' 73..79 CDD:409362 2/5 (40%)
Ig strand B 82..92 CDD:409362 0/9 (0%)
Ig strand C 96..101 CDD:409362 1/4 (25%)
Ig strand C' 104..106 CDD:409362 0/1 (0%)
Ig strand D 111..115 CDD:409362 1/3 (33%)
Ig strand E 118..123 CDD:409362 0/4 (0%)
Ig strand F 129..138 CDD:409362 1/8 (13%)
Ig strand G 141..151 CDD:409362 2/9 (22%)
IgI_2_FGFR 184..278 CDD:409443 33/93 (35%)
Ig strand A 184..187 CDD:409443 2/2 (100%)
Ig strand A' 195..200 CDD:409443 1/4 (25%)
Ig strand B 204..212 CDD:409443 1/7 (14%)
Ig strand C 218..223 CDD:409443 1/4 (25%)
Ig strand C' 226..228 CDD:409443 0/1 (0%)
Ig strand D 237..240 CDD:409443 0/2 (0%)
Ig strand E 244..249 CDD:409443 1/4 (25%)
Ig strand F 258..265 CDD:409443 5/6 (83%)
Ig strand G 268..278 CDD:409443 4/9 (44%)
Ig 286..390 CDD:472250 31/103 (30%)
Ig strand B 304..308 CDD:409353 0/3 (0%)
Ig strand C 317..321 CDD:409353 0/3 (0%)
Ig strand E 355..359 CDD:409353 1/3 (33%)
Ig strand F 369..374 CDD:409353 3/4 (75%)
Ig strand G 382..385 CDD:409353 0/2 (0%)
PTKc_FGFR1 495..796 CDD:270678 164/305 (54%)

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