DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and FES

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001996.1 Gene:FES / 2242 HGNCID:3657 Length:822 Species:Homo sapiens


Alignment Length:338 Identity:114/338 - (33%)
Similarity:169/338 - (50%) Gaps:36/338 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   358 IFKPEGGGDSSGSM--DTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGA 420
            :::.||.|..|..:  |.::.....:.|:...||...          .|.| .|.|....||||.
Human   512 LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRA----------VPKD-KWVLNHEDLVLGE 565

  Fly   421 TLGEGAFGRVVMAEV--NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQN 483
            .:|.|.||.|....:  :|.:||||..:|....|..|..::|..::|... |.||:.|:|.|:|.
Human   566 QIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYS-HPNIVRLIGVCTQK 629

  Fly   484 GPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLA 548
            .|:|:::|....|   |||...|..|..                :..|.|::.....|.||:||.
Human   630 QPIYIVMELVQGG---DFLTFLRTEGAR----------------LRVKTLLQMVGDAAAGMEYLE 675

  Fly   549 SRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSK 613
            |:.||||||||||.||::..||||:|||::|:.....|.......::|:||.|||:|....|.|:
Human   676 SKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSE 740

  Fly   614 SDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDR 678
            |||||:||||||..:.|..|||. :|.::...::..|.|:..|..|...::.||.|||.:....|
Human   741 SDVWSFGILLWETFSLGASPYPN-LSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 804

  Fly   679 PPFTEIVEYMDKL 691
            |.|:.|.:.:..:
Human   805 PSFSTIYQELQSI 817

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353
Ig strand F 171..176 CDD:409353
Ig strand G 184..187 CDD:409353
Ig 200..289 CDD:472250
Ig strand B 216..220 CDD:409353
Ig strand C 229..233 CDD:409353
Ig strand E 255..259 CDD:409353
Ig strand F 269..274 CDD:409353
Ig strand G 282..285 CDD:409353
Protein Kinases, catalytic domain 404..692 CDD:473864 106/290 (37%)
FESNP_001996.1 Important for interaction with membranes containing phosphoinositides 1..300
F-BAR_Fes 7..239 CDD:153369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..421
SH2_Fps_family 453..537 CDD:198224 5/24 (21%)
PTKc_Fes 564..815 CDD:270667 99/271 (37%)
Blue background indicates that the domain is not in the aligned region.

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